{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=curation_notes.txt"],"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079-biopax2.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079_url.xml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=manifest.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079-octave.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079-matlab.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=curation_image.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079_url.sedml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079.ode","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=metadata.rdf","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000079?filename=BIOMD0000000079.png"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Enuo He"],"curationStatus":["Manually curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V4"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/BIOMD0000000079"],"publication_pubmed":["16595882"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Goldbeter2006 weightCycling"],"publication_year":["2006"],"submissionId":["MODEL4644593552"],"publication_authors":["Albert Goldbeter"],"first_author":["Albert Goldbeter"],"publication":["16595882,\n                            The resolution to lose weight by cognitive restraint of nutritional intake often leads to repeated bouts of weight loss and regain, a phenomenon known as weight cycling or \"yo-yo dieting\". A simple mathematical model for weight cycling is presented. The model is based on a feedback of psychological nature by which a subject decides to reduce dietary intake once a threshold weight is exceeded. The analysis of the model indicates that sustained oscillations in body weight occur in a parameter range bounded by critical values. Only outside this range can body weight reach a stable steady state. The model provides a theoretical framework that captures key facets of weight cycling and suggests ways to control the phenomenon. The view that weight cycling represents self-sustained oscillations has indeed specific implications. In dynamical terms, to bring weight cycling to an end, parameter values should change in such a way as to induce the transition of body weight from sustained oscillations around an unstable steady state to a stable steady state. Maintaining weight under a critical value should prevent weight cycling and allow body weight to stabilize below the oscillatory range.. 1, 31.\n                            Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium. agoldbet@ulb.ac.be"],"submitter_mail":["enuo.he@wolfson.ox.ac.uk"],"submitter_affiliation":["University of Oxford"],"publicationId":["BIOMD0000000079"],"pubmed_abstract":["The resolution to lose weight by cognitive restraint of nutritional intake often leads to repeated bouts of weight loss and regain, a phenomenon known as weight cycling or \"yo-yo dieting\". A simple mathematical model for weight cycling is presented. The model is based on a feedback of psychological nature by which a subject decides to reduce dietary intake once a threshold weight is exceeded. The analysis of the model indicates that sustained oscillations in body weight occur in a parameter range bounded by critical values. Only outside this range can body weight reach a stable steady state. The model provides a theoretical framework that captures key facets of weight cycling and suggests ways to control the phenomenon. The view that weight cycling represents self-sustained oscillations has indeed specific implications. In dynamical terms, to bring weight cycling to an end, parameter values should change in such a way as to induce the transition of body weight from sustained oscillations around an unstable steady state to a stable steady state. Maintaining weight under a critical value should prevent weight cycling and allow body weight to stabilize below the oscillatory range."],"pubmed_title":["A model for the dynamics of human weight cycling."],"pubmed_authors":["Goldbeter Albert A"],"additional_accession":[]},"is_claimable":false,"name":"Goldbeter2006_weightCycling","description":"\n      \n        This model is according to the paper of      A model for the dynamics of human weight cycling\n          by A. Goldbeter 2006.The figure3 (A) and (B) have been reproduced by Copasi 4.0.19(development) and SBMLodeSolver.The writer of the paper did not specify any units for the metabolites, so the creator of the model did not define the units as well.Both Q and R are normalized to vary between 0 and 1.      \n            \n            To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n            In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.\n            \n            To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n                \n            \n      \n    ","dates":{"last_modification":"2024-08-21","publication":"2024-09-02","submission":"2006-11-27"},"accession":"BIOMD0000000079","cross_references":{"pubmed":["16595882"],"biomodels__db":["MODEL4644593552","BIOMD0000000079"],"go":["GO:0040014","GO:0035264","GO:0040018","GO:0040015","GO:0007631","GO:0002023","GO:0048520","GO:0048521"],"taxonomy":["9606"]}}