{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=curation_notes.txt"],"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114-biopax2.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114_url.xml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=manifest.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114.sci","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=metadata.rdf","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114-octave.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114-matlab.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114.ode","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=curation_image.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114_url.sedml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000114?filename=BIOMD0000000114.png"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"submitter":["Enuo He"],"curationStatus":["Manually curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V1"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/BIOMD0000000114"],"publication_pubmed":["1904060"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Somogyi1990 CaOscillations"],"publication_year":["1991"],"submissionId":["MODEL8907365389"],"publication_authors":["R Somogyi, J W Stucki"],"first_author":["R Somogyi"],"publication":["1904060,\n                            Hormone-induced oscillations of the free intracellular calcium concentration are thought to be relevant for frequency encoding of hormone signals. In liver cells, such Ca2+ oscillations occur in response to stimulation by hormones acting via phosphoinositide breakdown. This observation may be explained by cooperative, positive feedback of Ca2+ on its own release from one inositol 1,4,5-trisphosphate-sensitive pool, obviating oscillations of inositol 1,4,5-trisphosphate. The kinetic rate laws of the associated model have a mathematical structure reminiscent of the Brusselator, a hypothetical chemical model involving a rather improbable trimolecular reaction step, thus giving a realistic biological interpretation to this hallmark of dissipative structures. We propose that calmodulin is involved in mediating this cooperativity and positive feedback, as suggested by the presented experiments. For one, hormone-induced calcium oscillations can be inhibited by the (nonphenothiazine) calmodulin antagonists calmidazolium or CGS 9343 B. Alternatively, in cells overstimulated by hormone, as characterized by a non-oscillatory elevated Ca2+ concentration, these antagonists could again restore sustained calcium oscillations. The experimental observations, including modulation of the oscillations by extracellular calcium, were in qualitative agreement with the predictions of our mathematical model.. 17, 266.\n                            Pharmakologisches Institut, Universität Bern, Switzerland."],"submitter_mail":["enuo.he@wolfson.ox.ac.uk"],"submitter_affiliation":["University of Oxford"],"publicationId":["BIOMD0000000114"],"pubmed_abstract":["Hormone-induced oscillations of the free intracellular calcium concentration are thought to be relevant for frequency encoding of hormone signals. In liver cells, such Ca2+ oscillations occur in response to stimulation by hormones acting via phosphoinositide breakdown. This observation may be explained by cooperative, positive feedback of Ca2+ on its own release from one inositol 1,4,5-trisphosphate-sensitive pool, obviating oscillations of inositol 1,4,5-trisphosphate. The kinetic rate laws of the associated model have a mathematical structure reminiscent of the Brusselator, a hypothetical chemical model involving a rather improbable trimolecular reaction step, thus giving a realistic biological interpretation to this hallmark of dissipative structures. We propose that calmodulin is involved in mediating this cooperativity and positive feedback, as suggested by the presented experiments. For one, hormone-induced calcium oscillations can be inhibited by the (nonphenothiazine) calmodulin antagonists calmidazolium or CGS 9343 B. Alternatively, in cells overstimulated by hormone, as characterized by a non-oscillatory elevated Ca2+ concentration, these antagonists could again restore sustained calcium oscillations. The experimental observations, including modulation of the oscillations by extracellular calcium, were in qualitative agreement with the predictions of our mathematical model."],"pubmed_title":["Hormone-induced calcium oscillations in liver cells can be explained by a simple one pool model."],"pubmed_authors":["Somogyi R R, Stucki J W JW"],"additional_accession":[]},"is_claimable":false,"name":"Somogyi1990_CaOscillations","description":"\n      \n        This model encoded according to the paper      Hormone induced Calcium Oscillations in Liver Cells Can Be Explained by a Simple One Pool Model.\n          The values of parameters a and alpha are varioused inorder to simulate results in different situations. For Figure 3A, a=3.5,alpha=1.2 ; Figure 3B, a=3,alpha=5 ; Figure 3C a= 0.95, alpha=1.5; Figure3D, a=1, alpha=5. Keep in mind that the value for the xy axies are arbitrary value. Figures3 in the paper are reproduced by COPASI 4.0.20(development) , and SBMLodeSolver online.      \n            \n            To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n            In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.\n            \n            To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n                \n            \n      \n    ","dates":{"last_modification":"2024-08-21","publication":"2024-09-02","submission":"2007-06-05"},"accession":"BIOMD0000000114","cross_references":{"pubmed":["1904060"],"chebi":["CHEBI:29108"],"biomodels__db":["MODEL8907365389","BIOMD0000000114"],"go":["GO:0006816","GO:0019722","GO:0007204","GO:0051924","GO:0009755","GO:0005737","GO:0005783","GO:0005576","GO:0032471","GO:0051481","GO:0005388","GO:0051482","GO:0005220"],"kegg__compound":["C00076"],"taxonomy":["10114"]}}