{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=curation_notes.txt"],"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117-biopax2.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=manifest.xml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117_url.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117_url.sedml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117.ode","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117-matlab.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117-octave.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=curation_image.jpeg","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=BIOMD0000000117.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000117?filename=metadata.rdf"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Enuo He"],"curationStatus":["Manually curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V1"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/BIOMD0000000117"],"publication_pubmed":["1647878"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Dupont1991 CaOscillation"],"publication_year":["1991"],"submissionId":["MODEL0466937756"],"publication_authors":["G Dupont, M J Berridge, A Goldbeter"],"first_author":["G Dupont"],"publication":["1647878,\n                            We consider a simple, minimal model for signal-induced Ca2+ oscillations based on Ca(2+)-induced Ca2+ release. The model takes into account the existence of two pools of intracellular Ca2+, namely, one sensitive to inositol 1,4,5 trisphosphate (InsP3) whose synthesis is elicited by the stimulus, and one insensitive to InsP3. The discharge of the latter pool into the cytosol is activated by cytosolic Ca2+. Oscillations in cytosolic Ca2+ arise in this model either spontaneously or in an appropriate range of external stimulation; these oscillations do not require the concomitant, periodic variation of InsP3. The following properties of the model are reviewed and compared with experimental observations: (a) Control of the frequency of Ca2+ oscillations by the external stimulus or extracellular Ca2+; (b) correlation of latency with period of Ca2+ oscillations obtained at different levels of stimulation; (c) effect of a transient increase in InsP3; (d) phase shift and transient suppression of Ca2+ oscillations by Ca2+ pulses, and (e) propagation of Ca2+ waves. It is shown that on all these counts the model provides a simple, unified explanation for a number of experimental observations in a variety of cell types. The model based on Ca(2+)-induced Ca2+ release can be extended to incorporate variations in the level of InsP3 as well as desensitization of the InsP3 receptor; besides accounting for the phenomena described by the minimal model, the extended model might also account for the occurrence of complex Ca2+ oscillations.. 2-3, 12.\n                            Faculté des Sciences, Université Libre de Bruxelles, Belgium."],"submitter_mail":["enuo.he@wolfson.ox.ac.uk"],"submitter_affiliation":["University of Oxford"],"publicationId":["BIOMD0000000117"],"pubmed_abstract":["We consider a simple, minimal model for signal-induced Ca2+ oscillations based on Ca(2+)-induced Ca2+ release. The model takes into account the existence of two pools of intracellular Ca2+, namely, one sensitive to inositol 1,4,5 trisphosphate (InsP3) whose synthesis is elicited by the stimulus, and one insensitive to InsP3. The discharge of the latter pool into the cytosol is activated by cytosolic Ca2+. Oscillations in cytosolic Ca2+ arise in this model either spontaneously or in an appropriate range of external stimulation; these oscillations do not require the concomitant, periodic variation of InsP3. The following properties of the model are reviewed and compared with experimental observations: (a) Control of the frequency of Ca2+ oscillations by the external stimulus or extracellular Ca2+; (b) correlation of latency with period of Ca2+ oscillations obtained at different levels of stimulation; (c) effect of a transient increase in InsP3; (d) phase shift and transient suppression of Ca2+ oscillations by Ca2+ pulses, and (e) propagation of Ca2+ waves. It is shown that on all these counts the model provides a simple, unified explanation for a number of experimental observations in a variety of cell types. The model based on Ca(2+)-induced Ca2+ release can be extended to incorporate variations in the level of InsP3 as well as desensitization of the InsP3 receptor; besides accounting for the phenomena described by the minimal model, the extended model might also account for the occurrence of complex Ca2+ oscillations."],"pubmed_title":["Signal-induced Ca2+ oscillations: properties of a model based on Ca(2+)-induced Ca2+ release."],"pubmed_authors":["Dupont G G, Berridge M J MJ, Goldbeter A A"],"additional_accession":[]},"is_claimable":false,"name":"Dupont1991_CaOscillation","description":"\n      \n        This model is according to the paper      Signal-induced Ca2+ oscillations: Properties of a model based on Ca2+-induced Ca2+ release.\n          Figure4B in the paper has been reproduced by RoadRunner and MathSBML. Damped Ca2+ oscillations elicited by a transient pulse of InsP3 applied intracellularly to a resting, non-oscillatory cell.      \n            \n            To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n            In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.\n            \n            To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n                \n            \n      \n    ","dates":{"last_modification":"2024-08-21","publication":"2024-09-02","submission":"2007-06-05"},"accession":"BIOMD0000000117","cross_references":{"pubmed":["1647878"],"chebi":["CHEBI:29108"],"biomodels__db":["MODEL0466937756","BIOMD0000000117"],"go":["GO:0006816","GO:0051481","GO:0007204","GO:0019722","GO:0005576","GO:0048763","GO:0005829","GO:0044424","GO:0005388"],"kegg__compound":["C00076"],"taxonomy":["131567"]}}