BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=curation_notes.txthttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138.pdfhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138-biopax2.owlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138-biopax3.owlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=manifest.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138-octave.mhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=metadata.rdfhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138-matlab.mhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=curation_image.pnghttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138.pnghttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138_url.sedmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138.mhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000138?filename=BIOMD0000000138.odeprimaryOK200Enuo HeManually curatedordinary differential equation modelL2V1https://www.ebi.ac.uk/biomodels/BIOMD000000013817058022falseBioModelsSBMLModelsTabak2007 dopamine2007MODEL6090663405Joël Tabak, Natalia Toporikova, Marc E Freeman, R BertramJoël Tabak17058022, Dopamine (DA) released from the hypothalamus tonically inhibits pituitary lactotrophs. DA (at micromolar concentration) opens potassium channels, hyperpolarizing the lactotrophs and thus preventing the calcium influx that triggers prolactin hormone release. Surprisingly, at concentrations approximately 1000 lower, DA can stimulate prolactin secretion. Here, we investigated whether an increase in a K+ current could mediate this stimulatory effect. We considered the fast K+ currents flowing through large-conductance BK channels and through A-type channels. We developed a minimal lactotroph model to investigate the effects of these two currents. Both IBK and IA could transform the electrical pattern of activity from spiking to bursting, but through distinct mechanisms. IBK always increased the intracellular Ca2+ concentration, while IA could either increase or decrease it. Thus, the stimulatory effects of DA could be mediated by a fast K+ conductance which converts tonically spiking cells to bursters. In addition, the study illustrates that. 2, 22. Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. joel@neuro.fsu.eduenuo.he@wolfson.ox.ac.ukUniversity of OxfordBIOMD0000000138Dopamine (DA) released from the hypothalamus tonically inhibits pituitary lactotrophs. DA (at micromolar concentration) opens potassium channels, hyperpolarizing the lactotrophs and thus preventing the calcium influx that triggers prolactin hormone release. Surprisingly, at concentrations approximately 1000 lower, DA can stimulate prolactin secretion. Here, we investigated whether an increase in a K+ current could mediate this stimulatory effect. We considered the fast K+ currents flowing through large-conductance BK channels and through A-type channels. We developed a minimal lactotroph model to investigate the effects of these two currents. Both IBK and IA could transform the electrical pattern of activity from spiking to bursting, but through distinct mechanisms. IBK always increased the intracellular Ca2+ concentration, while IA could either increase or decrease it. Thus, the stimulatory effects of DA could be mediated by a fast K+ conductance which converts tonically spiking cells to bursters. In addition, the study illustrates thatLow dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents.Tabak Joël J, Toporikova Natalia N, Freeman Marc E ME, Bertram Richard RfalseTabak2007_dopamine The model is encoded according to the paper Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents Figure5 has been reproduced by MathSBML. One need to change the value of ga in order to get the three correct results. the xppaut file of the model is avaiable on the following address offered by the author , http://www.math.fsu.edu/%7Ebertram/software/pituitary/JCNS_07.ode To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92. 2024-08-212024-09-022007-08-08BIOMD000000013817058022CHEBI:29108MODEL6090663405BIOMD0000000138GO:0005623GO:0014046GO:1902211GO:0005267GO:0042391GO:0005251GO:0015459GO:0043267GO:0006816C000767711