{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=curation_notes.txt"],"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159.pdf"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159.svg"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159-biopax2.owl"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159_url.xml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=manifest.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159.ode","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159.sci","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=metadata.rdf","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159_url.sedml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159-octave.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=BIOMD0000000159-matlab.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000159?filename=curation_image.jpeg"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Harish Dharuri"],"curationStatus":["Manually curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V1"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/BIOMD0000000159"],"publication_pubmed":["16773083"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Zatorsky2006 p53 Model1"],"publication_year":["2006"],"submissionId":["MODEL0076281110"],"publication_authors":["Naama Geva-Zatorsky, Nitzan Rosenfeld, Shalev Itzkovitz, Ron Milo, Alex Sigal, Erez Dekel, Talia Yarnitzky, Yuvalal Liron, Paz Polak, Galit Lahav, Uri Alon"],"first_author":["Naama Geva-Zatorsky"],"publication":["16773083,\n                            Understanding the dynamics and variability of protein circuitry requires accurate measurements in living cells as well as theoretical models. To address this, we employed one of the best-studied protein circuits in human cells, the negative feedback loop between the tumor suppressor p53 and the oncogene Mdm2. We measured the dynamics of fluorescently tagged p53 and Mdm2 over several days in individual living cells. We found that isogenic cells in the same environment behaved in highly variable ways following DNA-damaging gamma irradiation: some cells showed undamped oscillations for at least 3 days (more than 10 peaks). The amplitude of the oscillations was much more variable than the period. Sister cells continued to oscillate in a correlated way after cell division, but lost correlation after about 11 h on average. Other cells showed low-frequency fluctuations that did not resemble oscillations. We also analyzed different families of mathematical models of the system, including a novel checkpoint mechanism. The models point to the possible source of the variability in the oscillations: low-frequency noise in protein production rates, rather than noise in other parameters such as degradation rates. This study provides a view of the extensive variability of the behavior of a protein circuit in living human cells, both from cell to cell and in the same cell over time.. null, 2.\n                            Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel."],"submitter_mail":["hdharuri@cds.caltech.edu"],"submitter_affiliation":["California Institute of Technology"],"publicationId":["BIOMD0000000159"],"pubmed_abstract":["Understanding the dynamics and variability of protein circuitry requires accurate measurements in living cells as well as theoretical models. To address this, we employed one of the best-studied protein circuits in human cells, the negative feedback loop between the tumor suppressor p53 and the oncogene Mdm2. We measured the dynamics of fluorescently tagged p53 and Mdm2 over several days in individual living cells. We found that isogenic cells in the same environment behaved in highly variable ways following DNA-damaging gamma irradiation: some cells showed undamped oscillations for at least 3 days (more than 10 peaks). The amplitude of the oscillations was much more variable than the period. Sister cells continued to oscillate in a correlated way after cell division, but lost correlation after about 11 h on average. Other cells showed low-frequency fluctuations that did not resemble oscillations. We also analyzed different families of mathematical models of the system, including a novel checkpoint mechanism. The models point to the possible source of the variability in the oscillations: low-frequency noise in protein production rates, rather than noise in other parameters such as degradation rates. This study provides a view of the extensive variability of the behavior of a protein circuit in living human cells, both from cell to cell and in the same cell over time."],"pubmed_title":["Oscillations and variability in the p53 system."],"pubmed_authors":["Geva-Zatorsky Naama N, Rosenfeld Nitzan N, Itzkovitz Shalev S, Milo Ron R, Sigal Alex A, Dekel Erez E, Yarnitzky Talia T, Liron Yuvalal Y, Polak Paz P, Lahav Galit G, Alon Uri U"],"pubmed_abstract_synonyms":["ERBB2 Gene Amplification Negative, dmBest1, dp53, PNT-P1, CDH1 Wild-Type, Cytogenetically Normal, CEK Gene Mutation Negative, Addresses, Longterm., BCC7 Gene Mutation Negative, ESTRB Negative, ECT1 Gene Rearrangement Negative, DmelCG6264, TRT Promoter Mutation Negative, dmTAF[[II]]230, GNA11 Gene Mutation Negative, Normal Tissue, Met Proto-Oncogene (Hepatocyte Growth Factor Receptor) Gene Amplification Negative, analysis, Correlated, Employed, node-negative, 1, correlation, BRAF Wildtype, Analysis, H. pylori Negative, D-ets-2, Hepatitis B Virus Core Antibody Negative, No rearrangement detected, HER2/neu Gene Mutation Negative, M Phases, DAYS, Gamma Irradiation, cel, ESR Negative, FGFBR Gene Mutation Negative, M, KGFR Gene Mutation Negative, PDCD1L1 Negative, N, beta-Tub6D, Tissue, dmp53, T, Living Costs, MET Amplification Negative, HER2 Non-Amplified, PGR Negative, D17Mit170, DID, ATRX Mutation Negative, XNP Gene Mutation Negative, d, Mechanism Device, Transforming Genes, FMS-Like Tyrosine Kinase 2 Gene Rearrangement Negative, PAX8 Gene Rearrangement Negative, FGFR1 Rearrangement Negative, CG17117, days, dTAF[[II]]230, TP53 Gene Mutation Negative, Anti-HBc Negative, Serum CA 19-9 Normal, Isogeneic, TP53 Mutation Negative, Pollution, Longterm Effect, BRAF wt, Measured Tumor Identification, Normal skin, Brother, Normalcy, Tl3, Tl2, 1p/19q Co-deletion Negative, Human Immunodeficiency Virus Negative, TMEM16A Negative, Economic Condition, bis(2-chloroethyl)sulfane, Do, CTNNB1 Wildtype, About, secretion, LCAM Gene Mutation Negative, Flavoprotein Subunit of Complex II Negative, Ret Proto-Oncogene Rearrangement Negative, FGFR3 Wild-Type, HTH, pntP2, Model System, Consumer Price Indices, Ets94F, CG3401, beta3Tub, Employment, Androgen Receptor Negative, B7-H Negative, Present, surveillance, Home, c-KIT Negative, Condition, p16INK4a Negative, v-Ets Erythroblastosis Virus E26 Oncogene Like Gene Rearrangement Negative, Oncogene, Taf250, ATRX Gene Mutation Negative, Unmethylated O-6-Methylguanine-DNA Methyltransferase Gene Promoter, GT, EBV Negative, ds DNA, TRP53 Gene Mutation Negative, B7H1 Negative, DNA, Feedbacks, Hepatitis B Core Antibody Negative, Policies, 0998/12, Labeled, DNS, (Deoxyribonucleotide)n, HER-2 Gene Mutation Negative, B-RAF1 Gene Rearrangement Negative, Alpha Thalassemia/Mental Retardation Syndrome X-Linked Gene Mutation Negative, Anti-HBc Antibody Negative, 143391_i_at, Analytical, Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, beta3 TU, cellular catabolism, l(3)05745, DMPOINT1A, SDHF Negative, Deoxyribonucleic Acid, BRCA1 Associated Protein 1 Gene Mutation Negative, K-SAM Gene Mutation Negative, Gene Products, Nuclear Receptor Subfamily 3 Group A Member 2 Negative, N-SAM Gene Rearrangement Negative, NRAS Wildtype, CD333 Gene Mutation Negative, Expression Negative, KRAS Wildtype, GNA11 Wild-Type, ETV Rearrangement Negative, ESR1 Negative, c-MET Gene Amplification Negative, Cadherin-Associated Protein, In, B-RAF1 Gene Mutation Negative, anatomical systems, dTAF[[II]]250, Transforming Gene, Cell Division Phase, pointed-RC, Longterm, Tissues, cell, VMD2, FGFR1 Gene Mutation Negative, FGFR-2 Gene Mutation Negative, CDH1 Mutation Negative, prevalence, Tagged, Double Stranded, FGFR-2 Gene Rearrangement Negative, BMD, SDHA Negative, EK3-2, KRAS2 Gene Mutation Negative, bis(2-chloroethyl) sulphide, dTAF250, Alpha 11 Gene Mutation Negative, RAD54 Homolog Gene Mutation, Mathematical, Estrogen Receptor Alpha Negative, ETV Family Rearrangement Negative, FLT2 Gene Mutation Negative, Keratinocyte Growth Factor Receptor Gene Rearrangement Negative, ERBB2 wt, Checkpoint, p53 Gene Mutation Negative, HBsAg Negative, beta[[3]]-tubulin, (Deoxyribonucleotide)m, MDM2, Including, NORMAL, RP50, New, Hepatitis B Virus Surface Antibody Negative, Ets, Q Polypeptide Gene Mutation Negative, cou, Fibroblast Growth Factor Receptor 1 Gene Rearrangement Negative, degradation, ETS Transcription Factor ERG Gene Rearrangement Negative, DNAn+1, Harvey Rat Sarcoma Viral Oncogene Homolog Gene Mutation Negative, prac, SDHIP Negative, Factor, FGFR2 Wild-Type, Negative Number, nev, dTAF230, Beta Catenin Gene Mutation Negative, del(10q23)/PTEN Gene Locus Deletion Negative, Lr, CTNNB1 Gene Mutation Negative, ATRX, MT, native protein, Consumer Price, Long Term Effects, TP53 wt, Alpha-11 Gene Mutation Negative, Hepatitis B Surface Protein Antigen Negative, NEGATIVE, pnt-P1, pnt-P2, Paired Domain Gene 8 Gene Rearrangement Negative, Taf[[II]]250, BEK Gene Mutation Negative, Unmethylated MGMT Promoter, Sibling, Accuracy, Dm-P53, Mdm-2, Understanding, ERBB2 Wildtype, Tub, High, No, Differential, Lack of Expression of PD-L1, Catenin Beta 1 Gene Mutation Negative, betatub60D, Desoxyribonukleinsaeure, Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit, Double Immunodiffusion, POINT, Anti-Hepatitis B Core Antibody Negative, CG8705, biochemical pathways, LFS1 Gene Mutation Negative, Normal Male External Genitalia, Approximate, BAP1 Wildtype, Telomerase Reverse Transcriptase Gene Promoter Mutation Negative, Greater Than, protein, Pnt, Human Herpesvirus-4 Negative, Tp53, Readability, DMP53, png, cellular degradation, ESR2 Negative, Transforming, protein aggregate, ORAOV2 Negative, Microeconomic, ATRX Wildtype, BRAF Mutation Negative, 1323/07, Continuous, ESR-Beta Negative, Average Amount, Household Consumption, CD274 Negative, Iprit, Keratinocyte Growth Factor Receptor Gene Mutation Negative, BAP1 wt, T1, PAX8 Rearrangement Negative, Division Phase, How Often Felt Normal, Novel, Chromatin Remodeler Gene Mutation Negative, FGFR-1 Gene Rearrangement Negative, Erb-B2 Receptor Tyrosine Kinase Gene Mutation Negative, Subsequent, Normal, None detected, BAP1 Wild-Type, biotransformation, Theories, ER-Alpha Negative, Long-Term Effects, None Detected, SDHB Loss, Ha-ras Gene Mutation Negative, Noise, GNA-11 Gene Mutation Negative, GNAQ Wildtype, Growl, Home Economics, CG6264, HBsAb Negative, Label, Hypothesis, FGFR-1 Gene Mutation Negative, Negative, D-Ets-2, scan tracer used, ets94F, Double-Stranded, TAFII-250, TAF250/230, FLT-2 Gene Mutation Negative, BRAF Wild Type, Economics, Syngenic, (Deoxyribonucleotide)n+m, Ets Variant Gene Family Rearrangement Negative, TAFII250, ESRA Negative, FGFR3 Rearrangement Negative, KAL2 Gene Mutation Negative, MEASURED, ESTRR Negative, Continuing, Fibroblast Growth Factor Receptor 2 Gene Mutation Negative, Tub60D, dBest1, FGFR2 Mutation Negative, Possibly Related, p16INK4 Negative, Isogenic, beta-tub, Guanine Nucleotide Binding Protein (G Protein), Factors, Continue, HHV-4 Negative, HRAS Gene Mutation Negative, E-Cadherin Gene Mutation Negative, estrogen receptor negative, CG17603, TAF[[II]], 1p/19q Intact, HER2 Wildtype, ptd, PntP2, FLT-2 Gene Rearrangement Negative, PntP1, E(E2F)3D, P53, p44, Tumor Protein p53 Gene Mutation Negative, Sisters, Noise Pollution, Unmethylated MGMT Gene Promoter, Remittances, PR Negative, Normal Chest Appearance, KAL2 Gene Rearrangement Negative, tissue, p50, ACTFS, Math, GAQ Gene Mutation Negative, ETS2, p53, Negative Finding, v-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog Negative, dTAFII250, Deoxyribonucleic acids, JKT4 Gene Mutation Negative, FGFR1 Wildtype, Neuroblastoma RAS Viral Oncogene Homolog Gene Mutation Negative, 0608/07, syngeneic, Homo sapiens, OGD Gene Mutation Negative, dmTAF1, SDHB Deficient, DOUBLE IMMUNODIFFUSION, Mustard gas, Low, Anti-Hepatitis B Virus Surface Antibody Negative, c-K-ras Gene Mutation Negative, TAF250, MET Proto-Oncogene, Mitochondrial Negative, study, Measured, NR3A1 Negative, clone 2.13, PRESENT, HHV4 Negative, ANALYSIS, NRAS Wild-Type, D.m.BETA-60D, GNA11 Wildtype, Mechanism, hdm2, Normal Gait, G-ALPHA-q Gene Mutation Negative, PDL1 Negative, growl, Economic Conditions, FGFR1 Gene Rearrangement Negative, CD331 Gene Mutation Negative, Lost, p16(INK4a) Negative, Reporter, Erg-3 Gene Rearrangement Negative, Found, Normal Abdomen on Visual Inspection, N-RAS Gene Mutation Negative, beta3-tubulin, Long-Term Effect, TRP53, Several days, TAF, l(3)j1B7, Day, incidence, sulfur mustard, KGFR Gene Rearrangement Negative, beta-Tub60D, Deidentification, CD332 Gene Rearrangement Negative, Succinate Dehydrogenase Complex Flavoprotein Subunit A Negative, TAF[[II]]250, HDMX, Syngeneic, Dm-HTH, FLG Gene Rearrangement Negative, Beta Gene Mutation Negative, protein complex, FGFR3 Gene Mutation Negative, More Than, beta3-Tub, FGFR1 Mutation Negative, l(3)84Ab, Normal Precordial Palpation Finding, Production, day, Xp53, Anti-HBs Antibody Negative, Impact, Consumption, Environmental, tracer, p230, GNA11 wt, ds-DNA, M Phase, l(3)s118306, Acceptance, Anoctamin-1 Negative, ER Beta Negative, Genes, TAF[[II]]230, UVO Gene Mutation Negative, biodegradation, ERBB2 Mutation Negative, Normality, FGFR3 wt, Succinate Dehydrogenase Complex Iron Sulfur Subunit B Negative, Senfgas, AA415488, KIT Negative, l(3)86Ca, ERA Negative, OGD Gene Rearrangement Negative, B-RAF Gene Mutation Negative, CTNNB1 wt, Calcium-Dependent Adhesion Protein, Absent, Noises, Accurate, Protein Gene Products, SDH1 Negative, NEU Gene Amplification Negative, DmelCG17603, GTPase Gene Mutation Negative, CD324 Gene Mutation Negative, B7 Homolog 1 Negative, Cost of Living, IDH wt Allele, BAP1 Gene Mutation Negative, Ongoing, TAF1, Much, CDKN2A-p16(INK4a) Negative, Cyclin-Dependent Kinase 4 Inhibitor A Negative, Hepatitis B Surface Antigen Negative, Phases, EY3-1, GNAQ Gene Mutation Negative, CDH1 Wildtype, Divisions, UCHL2 Gene Mutation Negative, Long Term, Nuclear Receptor Subfamily 3 Group A Member 1 Negative, GNAQ Mutation Negative, Progesterone Receptor Negative, FGFR-3 Gene Mutation Negative, H-ras Gene Mutation Negative, Normal Appearance of the Extremities, bbl, C-HA-RAS1 Gene Mutation Negative, CDKN2A-p16 Negative, 3520, BEST1_HUMAN, v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene Rearrangement Negative, average, Correlation, Theory, HRas Proto-Oncogene, thymus nucleic acid, Loss of Expression, BFGFR Gene Rearrangement Negative, Utility Theories, TFIID TAF250, BCC7, catabolism, HBcAb Negative, Economic Policies, 1422/04, Isocitrate Dehydrogenase (NADP+) Gene Family Wildtype, Cytogenetic Abnormalities Absent, IP Negative, Normality-Based Dosing Unit, Days, Normal Capillary Refill Time, Did, Anti-HBsAb Negative, Dp53, Receptor Tyrosine Kinase Gene Amplification Negative, Catenin Beta-1 Gene Mutation Negative, Household Consumptions, Economic, Negative Charge, HBs Antigen Negative, p50/tubulin, FGFR-3 Gene Rearrangement Negative, ER Alpha Negative, ERB Negative, ERBB2 Wild-Type, FGFR1 wt, CG10873, CDH1 Gene Mutation Negative, Followed By, Indices, Index, Difference, CONTINUOUS, TAF200, MT (more than), Cell Divisions, Acceptance Processes, GNA11 Mutation Negative, CD117 Negative, Utility Theory, Cadherin, Helicobacter pylori Negative, bfy, Macroeconomic, Arc-1 Gene Mutation Negative, desoxyribose nucleic acid, TU15B, Hth, Tumor suppressor p53, Pointed-P1, Epstein Barr Virus Negative, Mathematics, EST2 Promoter Mutation Negative, HGFR Gene Amplification Negative, Guanine Nucleotide-Binding Protein, HRAS Mutation Negative, v-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 Gene Amplification Negative, dbest1, beta3TUB, Beta-Catenin Gene Mutation Negative, ATRX wt, human, DTB3, living, Anti-Hepatitis B Virus Core Antibody Negative, HBs Negative, TERT Promoter Mutation Negative, ERG Gene Rearrangement Negative, GNAQ wt, CDHE Gene Mutation Negative, CTNNB Gene Mutation Negative, MET Gene Amplification Negative, bhy, KRAS Gene Mutation Negative, Passive Double Immunodiffusion, CG31325, BRAF Gene Mutation Negative, TAF230, Epstein-Barr Virus Negative, c-Met Amplification Negative, beta[[3]]-Tub, DmelCG17117, HER2 Gene Mutation Negative, G Protein Subunit Alpha q Gene Mutation Negative, Not Expressed, Effects, Processes, Different, BEST1, On Average, Utility, Negative Estrogen Receptor, HER2 wt, protein-containing complex, model, LFS1, Theoretical, Human, Easterlin, ER-, CMC1 Gene Mutation Negative, FGFBR Gene Rearrangement Negative, Li-Fraumeni Syndrome Gene Mutation Negative, anon-EST:Liang-2.13, IDH Family Gene Mutation Negative, NRAS Gene Mutation Negative, Man, Higher, Negative Lymph Node, Normalities, RING-type E3 ubiquitin transferase Mdm2, Brothers, Normal Skin, FGFR3 Mutation Negative, occurrence, JKT4 Gene Rearrangement Negative, Microeconomic Factors, ZNF-HX Gene Mutation Negative, GA11 Gene Mutation Negative, Deoxyribonucleic acid, Ets Variant Family Rearrangement Negative, Paired Box Gene 8 Gene Rearrangement Negative, Long-Term, Division, PDCD1LG1 Negative, NEU Gene Mutation Negative, l(3)07825, Possible, del10q23/Phosphatase and Tensin Homolog Gene Locus Negative, Capital, CTNNB1 Wild-Type, NEG, ER-Beta Negative, CG17077, BRCA1-Associated Protein 1 Gene Mutation Negative, Programmed Cell Death 1 Ligand 1 Negative, Approximately, BFGFR Gene Mutation Negative, vitelliform macular dystrophy 2 (Best disease, TCS1 Promoter Mutation Negative, HER2/neu Gene Amplification Negative, cellular breakdown, oncoprotein Mdm2, Dmbeta3, Epithelial Gene Mutation Negative, FGFR3 Wildtype, 1-chloro-2-[(2-chloroethyl)thio]ethane, Conditions, Proteins, beta3t, BG:DS00004.13, CTNNB1 Mutation Negative, Hepatocyte Growth Factor Receptor Gene Amplification Negative, Cell, TERT Gene Promoter Mutation Negative, Consumer Price Index, p53/tubulin, KRAS Wild-Type, TAF[[II]]250/230, ATRX Wild-Type, CD333 Gene Rearrangement Negative, KIT Proto-Oncogene Tyrosine Protein Kinase Negative, outbreaks, ESRB Negative, B-RAF Gene Rearrangement Negative, RET Rearrangement Negative, BRAF Rearrangement Negative, CG33336, Phase, IDH Mutation Negative, Erb-B2 Receptor Tyrosine Kinase Gene Amplification Negative, best, p16 Negative, de-identification, PD-L1 Negative, HER2 Gene Amplification Negative, D-p53, Fibroblast Growth Factor Receptor 1 Gene Mutation Negative, beta3, Normal Appearance of Extremities, Normal Capillary Refill, RAD54L Gene Mutation Negative, Sister, dtl, Longterm Effects, Cell Cycle Checkpoint, Gene Proteins, Fibroblast Growth Factor Receptor 3 Gene Rearrangement Negative, IDP Gene Mutation Negative, NRAS Mutation Negative, CDH1 wt, ETV Family Gene Rearrangement Negative, ANO1 Negative, Bra, epidemics, FGFR1 Wild-Type, p16-INK4 Negative, BEST, CEK Gene Rearrangement Negative, Extensive, SWS Gene Mutation Negative, Adverse Event Possibly Related to Intervention, G Protein Subunit Alpha 11 Gene Mutation Negative, DmelCG17077, ER Negative, Possibly Related to Intervention, betaTub3, Highly, BRAF Gene Rearrangement Negative, Tracer, FLG Gene Mutation Negative, ARB, Impacts, Dmp53, HRAS Wild-Type, Human Herpesvirus 4 Negative, Environmental Impacts, gamma irradiation, Effect, BAP1 Mutation Negative, Pnt-P1, CD332 Gene Mutation Negative, me75, No mutation detected, Man (Taxonomy), pre-mortem, p55 Gene Rearrangement Negative, Cyclin-Dependent Kinase Inhibitor 2A Negative, CD331 Gene Rearrangement Negative, DmP53, Environmental Impact, B3t, DmelCG3401, CG14648, PR-, TP53 Wildtype, FGFR2 Gene Rearrangement Negative, mustard gas, Estrogen Receptor 2 Negative, FGFR2 Gene Mutation Negative, Analyzed, Double-Stranded DNA, deoxyribonucleic acids, DNAn, CD274 Molecule Negative, SDH2 Negative, v-Ha-ras Harvey Rat Sarcoma Viral Oncogene Homolog Gene Mutation Negative, Normal Thoracic Appearance, single-organism behavior, negative test result, FMS-Like Tyrosine Kinase 2 Gene Mutation Negative, Estrogen Receptor 1 Negative, Process, XH2 Gene Mutation Negative, Modern, frequency, Paired Box 8 Gene Rearrangement Negative, Hepatitis B Surface Antibody Negative, Normal Reference Range, 0123/09, NR3A2 Negative, Macroeconomic Factors, 3t, Menstruation, Acceptance Process, Household, HRAS wt, p53-binding protein Mdm2, NOS, Estrogen Receptor Negative, Conflict, Does, Normal Immune Presence, ETV Gene Rearrangement Negative, IDH Gene Family Wildtype, HER-2 Gene Amplification Negative, ERBB2 Gene Mutation Negative, RASH1 Gene Mutation Negative, IDH Gene Mutation Negative, Isocitrate Dehydrogenase Gene Family Wild Type, GNAQ Wild-Type, 10q23/PTEN Locus Deletion Negative, DmelCG33336, double minute 2 protein, Possible Attribution, BEK Gene Rearrangement Negative, Presence, morbidity, ECAD Gene Mutation Negative, hth1, Health, hth2, Easterlin Hypothesis, DOG1 Negative, SR3-5, View, v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Gene Mutation Negative, FGFR2 Wildtype, Hepatitis B Virus Surface Antigen Negative, PNTP2, PNTP1, betaTub, d230, human being, LOST, v-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 Gene Mutation Negative, Ets2, Correlative, IDH Family Wildtype, Gene, Yperite, anon-WO0118547.380, ECT1 Gene Mutation Negative, Continued, EfW1, Anti-HBcAb Negative, FGFR2 wt, ONGO, pntegfr, Taf230, FLT2 Gene Rearrangement Negative, CD274 Antigen Negative, 1700007J15Rik, HRAS Wildtype, Fp Negative, Negative Test Result, Anti-HBs Negative, Next, 1'-thiobis(2-chloroethane), Models, FGFR3 Gene Rearrangement Negative, N-SAM Gene Mutation Negative, Modeling System, Taf200, SDHB Deficiency, 1p/19q Codeletion Negative, breakdown of chemical, Ouchterlony Double Immunodiffusion, Mast/Stem Cell Growth Factor Receptor Kit Negative, Antigen NY-CO-13, anon-WO0118547.126, Taf1p, Cell Division, RAD54 Gene Mutation Negative, Phosphoprotein p53, Trp53, Several Days, TISSUE, Following, ONGOING, betaTub60C, Continual, DmelCG14648, Model, Behaviors, Tag, Cadherin 1 Gene Mutation Negative, DAY, Policy, v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene Mutation Negative, Economic Policy, AR Negative, RET Gene Rearrangement Negative, HIV Negative, NRAS wt, KRAS-2 Gene Mutation Negative, del(1p/19q) Negative, BETA 60D, FGFR2 Rearrangement Negative, ERBB2 Non-Amplified, Fibroblast Growth Factor Receptor 3 Gene Mutation Negative, Living Cost, KRAS wt, TP2 Promoter Mutation Negative, IDH Wild Type, Period, Normal Point of Maximum Impulse, HER2 Wild-Type, Protein, TFIID, Fibroblast Growth Factor Receptor 2 Gene Rearrangement Negative, ERG Rearrangement Negative, beta[[3]] tubulin, bestrophin), K-SAM Gene Rearrangement Negative, breakdown of molecule, progesterone receptor negative, Dbest, MGMT Gene Promoter Methylation Negative, beta60C, TAF[II]250, Unit of Concentration, RET/PTC Rearrangement Negative, Unmethylated Methylguanine-DNA Methyltransferase Gene Promoter, No abnormality detected, endemics, Meis1, breakdown of substance, Ets58AB, Estrogen Receptor Beta Negative, scan_tracer_used, Remittance, Modern Man, Environments, SDHB Negative, Inclusive, variable, TAOS2 Negative"],"description_synonyms":["extent, beta[[3]]-Tub, DmelCG17117, dp53, Sectors, Public Sectors, YB, p50, Effects, ACTFS, p53, AUTSX5, number, 143391_i_at, Copyrights, beta3 TU, NOVH, CCN3, LFS1, betaTub3, 2210402P09Rik, QM, Tp53, Long Term, l(3)05745, DMP53, Yb, 1700007J15Rik, bbl, Figs, Dmp53, anon-EST:Liang-2.13, Public Enterprise, Effect, Enterprises, CG2706, fs(1)M104, PIST, RING-type E3 ubiquitin transferase Mdm2, 1323/07, DmelCG7615, clone 2.13, BCC7, Longterm, D.m.BETA-60D, beta-Tub6D, Public Domains, dmp53, hdm2, AI844555, T, DmP53, 1422/04, Long-Term, IGFBP9, Public Enterprises, DEPP, Rubberplants, IBP-9, B3t, Kiaa4053, DmelCG3401, Trp53, Rubberplant, Dp53, L10, Fseg, betaTub60C, beta3-tubulin, Long-Term Effect, beta[[3]]-tubulin, TRP53, NOVh, CG17117, MDM2, Enterprise, Long-Term Effects, p50/tubulin, beta-Tub60D, Decidual protein induced by progesterone, CG10873, oncoprotein Mdm2, Dmbeta3, HDMX, Dm-HTH, completeness, DmelCG2706, BETA 60D, prac, beta3t, beta3-Tub, Longterm Effect, DXS648, results, Xp53, presence., 3t, Fasting-induced gene protein, count in organism, IGFBP-9, Public, Public Domain, p53-binding protein Mdm2, p53/tubulin, Long Term Effects, CAL, Domains, bfy, NOV, beta[[3]] tubulin, PlexA1, GOPC1, Tub60D, Domain, HTH, Hth, Data Base, CG33336, beta-tub, Plxn1, DmelCG33336, D-p53, beta60C, CG3401, double minute 2 protein, beta3Tub, beta3TUB, AA415488, nov, Dm-P53, l(3)86Ca, beta3, Mdm-2, mKIAA4053, dtl, fs(1)Y[b], Longterm Effects, dJ94G16.2, Tub, DTB3, Meis1, hth1, FIG, Fig, Sector, hth2, betatub60D, C130088N23Rik, P53, EG:95B7.8, CG7615, p44, bhy, 2600013D04Rik, PLXN1, DXS648E, CG31325, betaTub"],"pubmed_title_synonyms":["beta-Tub60D, beta[[3]]-Tub, CG10873, DmelCG17117, dp53, Dmbeta3, Dm-HTH, p50, p53, BETA 60D, prac, beta3t, beta3-Tub, 143391_i_at, beta3 TU, LFS1, betaTub3, Tp53, l(3)05745, Xp53, 3t, DMP53, bbl, p53/tubulin, Dmp53, bfy, beta[[3]] tubulin, anon-EST:Liang-2.13, Tub60D, HTH, Hth, CG33336, beta-tub, 1323/07, clone 2.13, BCC7, D.m.BETA-60D, beta-Tub6D, dmp53, DmelCG33336, D-p53, beta60C, CG3401, beta3Tub, beta3TUB, T, DmP53, Dm-P53, l(3)86Ca, 1422/04, beta3, dtl, Tub, DTB3, B3t, Meis1, DmelCG3401, hth1, Trp53, hth2, Dp53, betatub60D, P53, betaTub60C, p44, bhy, beta3-tubulin, beta[[3]]-tubulin, TRP53, anatomical systems., CG17117, CG31325, betaTub, p50/tubulin"],"additional_accession":[]},"is_claimable":false,"name":"Zatorsky2006_p53_Model1","description":"\n      \n        The model reproduces the time profile of p53 and Mdm2 as depicted in Fig 6B of the plot for model 1. Results obtained on MathSBML.\n            \n            To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n            In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.\n            \n            To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n                \n            \n      \n    ","dates":{"last_modification":"2024-08-21","publication":"2024-09-02","submission":"2008-01-14"},"accession":"BIOMD0000000159","cross_references":{"kegg__pathway":["hsa04115"],"pubmed":["16773083"],"biomodels__db":["MODEL0076281110","BIOMD0000000159"],"go":["GO:0030330","GO:0006412","GO:0042176","GO:0006351","GO:0044257"],"taxonomy":["9606"],"bto":["BTO:0000093"],"uniprot":["P04637","Q00987"],"doi":["10.1142/S0218339000000031"]}}