{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=curation_notes.txt"],"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169.pdf"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169.svg"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169-biopax2.owl"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169_url.xml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=manifest.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169.vcml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=curation_image.jpeg","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169_url.sedml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169.ode","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=metadata.rdf","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169-matlab.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000169?filename=BIOMD0000000169-octave.m"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Nicolas Le Novère"],"curationStatus":["Manually curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V1"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/BIOMD0000000169"],"publication_pubmed":["10619492"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Aguda1999 CellCycle"],"publication_year":["1999"],"submissionId":["MODEL3897395081"],"publication_authors":["B D Aguda, Y Tang"],"first_author":["B D Aguda"],"publication":["10619492,\n                            A detailed model mechanism for the G1/S transition in the mammalian cell cycle is presented and analysed by computer simulation to investigate whether the kinetic origins of the restriction point (R-point) can be identified. The R-point occurs in mid-to-late G1 phase and marks the transition between mitogen-dependent to mitogen-independent progression of the cell cycle. For purposes of computer simulations, the R-point is defined as the first point in time after mitosis where cutting off mitogen stimulation does not prevent the cell reaching the threshold activity of cyclin-E/cdk2 required for entry into S phase. The key components of the network that generate a dynamic switching behaviour associated with the R-point include a positive feedback loop between cyclin-E/cdk2 and Cdc25A, along with the mutually negative interaction between the cdk inhibitor p27Kip1 and cyclin-E/cdk2. Simulations of the passage through the R-point were carried out and the factors affecting the position of the R-point in G1 are determined. The detailed model also shows various points in the network where the activation of cyclin-E/cdk2 can be initiated with or without the involvement of the retinoblastoma protein.. 5, 32.\n                            Department of Chemistry & Biochemistry, Laurentian University, Sudbury, Ontario, Canada. daguda@nickel.laurentian.ca"],"submitter_mail":["lenov@ebi.ac.uk"],"submitter_affiliation":["EBML-EBI"],"publicationId":["BIOMD0000000169"],"pubmed_abstract":["A detailed model mechanism for the G1/S transition in the mammalian cell cycle is presented and analysed by computer simulation to investigate whether the kinetic origins of the restriction point (R-point) can be identified. The R-point occurs in mid-to-late G1 phase and marks the transition between mitogen-dependent to mitogen-independent progression of the cell cycle. For purposes of computer simulations, the R-point is defined as the first point in time after mitosis where cutting off mitogen stimulation does not prevent the cell reaching the threshold activity of cyclin-E/cdk2 required for entry into S phase. The key components of the network that generate a dynamic switching behaviour associated with the R-point include a positive feedback loop between cyclin-E/cdk2 and Cdc25A, along with the mutually negative interaction between the cdk inhibitor p27Kip1 and cyclin-E/cdk2. Simulations of the passage through the R-point were carried out and the factors affecting the position of the R-point in G1 are determined. The detailed model also shows various points in the network where the activation of cyclin-E/cdk2 can be initiated with or without the involvement of the retinoblastoma protein."],"pubmed_title":["The kinetic origins of the restriction point in the mammalian cell cycle."],"pubmed_authors":["Aguda B D BD, Tang Y Y"],"additional_accession":[]},"is_claimable":false,"name":"Aguda1999_CellCycle","description":"\n      \n        The model reproduces the time profiles of  p27, E2F and aE/cdk2 as depicted in Figure 5 c of the paper. Model was simulated on MathSBML.\n            \n            To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n            In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.\n            \n            To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n                \n            \n      \n    ","dates":{"last_modification":"2024-08-21","publication":"2024-09-02","submission":"2008-05-08"},"accession":"BIOMD0000000169","cross_references":{"reactome":["REACT_1538.1"],"pubmed":["10619492"],"biomodels__db":["MODEL3897395081","BIOMD0000000169"],"go":["GO:0031575"],"kegg__compound":["C00562"],"taxonomy":["40674"],"uniprot":["P24941","O96020","P24864","P11802","P46527","P42771"],"interpro":["IPR015633","IPR015652","IPR015451"]}}