BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=curation_notes.txthttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224.pdfhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224-biopax2.owlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224-biopax3.owlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=manifest.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224.odehttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224.pnghttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224_url.sedmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=curation_image.pnghttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224-matlab.mhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224.vcmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224.mhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=BIOMD0000000224-octave.mhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000224?filename=metadata.rdfprimaryOK200Philipp BayerManually curatedordinary differential equation modelL2V4https://www.ebi.ac.uk/biomodels/BIOMD00000002241867714falseBioModelsSBMLModelsMeyer1991 CalciumSpike ICC1991MODEL9412103933T Meyer, L StryerT Meyer1867714, null. null, 20. Department of Cell Biology, Sherman Fairchild Center, Stanford University School of Medicine, California 94305.p.bayer@stud.uni-heidelberg.deStanford University, University of HeidelbergBIOMD0000000224Many cells exhibit periodic transient increases in cytosolic calcium levels rather than a sustained rise when stimulated by a hormone or growth factor. We propose here a molecular model that accounts for periodic calcium spiking induced by a constant stimulus. Four elements give rise to repetitive calcium transients: cooperativity and positive feedback between a pair of reciprocally coupled (crosscoupled) messengers, followed by deactivation and then by reactivation. The crosscoupled messengers in our model are inositol 1,4,5-trisphosphate (InsP3) and cytosolic calcium ions. The opening of calcium channels in the endoplasmic reticulum by the binding of multiple molecules of InsP3 provides the required cooperativity. The stimulation of receptor-activated phospholipase C by released calcium ions leads to positive feedback. InsP3 is destroyed by a phosphatase, and calcium ion is pumped back into the endoplasmic reticulum. These processes generate bistability: the cytosolic calcium concentration abruptly increases from a basal level to a stimulated level at a threshold degree of activation of phospholipase C. Spiking further requires slow deactivation and subsequent reactivation. In our model, mitochondrial sequestration of calcium ion prevents the cytosolic level from increasing above several micromolar and enables the system to return to the basal state. When the endoplasmic reticulum calcium store is refilled to a critical level by the Ca2+-ATPase pump, cooperative positive feedback between the InsP3-gated channel and phospholipase C begins again to give the next calcium spike. The time required for the calcium level in the endoplasmic reticulum to reach a threshold sets the interval between spikes. The amplitude, shape, and period of calcium spikes calculated for this model are like those observed experimentally.Molecular model for receptor-stimulated calcium spiking.Calcium spiking.Meyer T T, Stryer L LfalseMeyer1991_CalciumSpike_ICC This a model from the article: Calcium spiking. Meyer T, Stryer L Annu Rev Biophys Biophys Chem1991:20:153-74 1867714, Abstract: No Abstract Available The IP3-Ca2+ Crosscoupling Model (ICC) is reviewed by Meyer and Stryer in 1991, originally from Meyer and Stryer, 1988. PMID - 2455890 Parameters refer to figures 5 and 6 of the article which were reproduced by using Copasi 4.5 (Build 30). Species CaI and IP3 are buffered to 1% and 50% percent, respectively. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.For more information see the terms of use.To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691. 2024-08-212024-09-022009-08-04BIOMD000000022418677142455890CHEBI:29108CHEBI:16595MODEL9412103933BIOMD0000000224GO:0051279GO:0005829GO:0005783GO:0019855GO:0051209GO:0060401GO:0032959GO:0032961C00076C0125510117