BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=curation_notes.txthttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337.pdfhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337-biopax2.owlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337-biopax3.owlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=manifest.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337_url.sedmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337.pnghttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=curation_image.pnghttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337.odehttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337-octave.mhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337-matlab.mhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=metadata.rdfhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000337?filename=BIOMD0000000337.mprimaryOK200Kieran SmallboneManually curatedordinary differential equation modelL2V4https://www.ebi.ac.uk/biomodels/BIOMD000000033711283355falseBioModelsSBMLModelsPfeiffer2001 ATP ProducingPathways CooperationCompetition2001MODEL1105120000T Pfeiffer, S Schuster, S BonhoefferT Pfeiffer11283355, Heterotrophic organisms generally face a trade-off between rate and yield of adenosine triphosphate (ATP) production. This trade-off may result in an evolutionary dilemma, because cells with a higher rate but lower yield of ATP production may gain a selective advantage when competing for shared energy resources. Using an analysis of model simulations and biochemical observations, we show that ATP production with a low rate and high yield can be viewed as a form of cooperative resource use and may evolve in spatially structured environments. Furthermore, we argue that the high ATP yield of respiration may have facilitated the evolutionary transition from unicellular to undifferentiated multicellular organisms.. 5516, 292. Friedrich Miescher Institute, Post Office Box 2543, CH-4002 Basel, Switzerland., Max Delbrück Center for Molecular Medicine, D-13092 Berlin, Germany.kieran.smallbone@ncl.ac.ukHuman Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK.BIOMD0000000337Heterotrophic organisms generally face a trade-off between rate and yield of adenosine triphosphate (ATP) production. This trade-off may result in an evolutionary dilemma, because cells with a higher rate but lower yield of ATP production may gain a selective advantage when competing for shared energy resources. Using an analysis of model simulations and biochemical observations, we show that ATP production with a low rate and high yield can be viewed as a form of cooperative resource use and may evolve in spatially structured environments. Furthermore, we argue that the high ATP yield of respiration may have facilitated the evolutionary transition from unicellular to undifferentiated multicellular organisms.Cooperation and competition in the evolution of ATP-producing pathways.Pfeiffer T T, Schuster S S, Bonhoeffer S SfalsePfeiffer2001_ATP-ProducingPathways_CooperationCompetition This model is from the article: Cooperation and Competition in the Evolution of ATP-Producing Pathways Thomas Pfeiffer, Stefan Schuster, Sebastian Bonhoeffer Science 2001 Apr; Volume:292 (Issue:5516); Page info:504-7 11283355 , Abstract: Heterotrophic organisms generally face a trade-off between rate and yield of adenosine triphosphate (ATP) production. This trade-off may result in an evolutionary dilemma, because cells with a higher rate but lower yield of ATP production may gain a selective advantage when competing for shared energy resources. Using an analysis of model simulations and biochemical observations, we show that ATP production with a low rate and high yield can be viewed as a form of cooperative resource use and may evolve in spatially structured environments. Furthermore, we argue that the high ATP yield of respiration may have facilitated the evolutionary transition from unicellular to undifferentiated multicellular organisms. Note: This model reproduces the competition and invasion described in Supplemental Figure 2. 2024-08-212024-09-022011-05-12BIOMD000000033711283355MODEL1105120000BIOMD0000000337PATO:0001021GO:0071318GO:0006754GO:0005623GO:0016049GO:0008219131567