BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000750?filename=Lolas2016.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000750?filename=Lolas2016.cpshttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000750?filename=Lolas2016.sedmlprimaryOK200Jinghao MenManually curatedordinary differential equation modelL3V1https://www.ebi.ac.uk/biomodels/BIOMD000000075026861829falseBioModelsSBMLModelsLolas2016 tumour induced neoneurogenesis and perineural tumour growth2016MODEL1907160001Lolas G, Bianchi A, Syrigos KNLolas G26861829,
It is well-known that tumours induce the formation of a lymphatic and a blood vasculature around themselves. A similar but far less studied process occurs in relation to the nervous system and is referred to as neoneurogenesis. The relationship between tumour progression and the nervous system is still poorly understood and is likely to involve a multitude of factors. It is therefore relevant to study tumour-nerve interactions through mathematical modelling: this may reveal the most significant factors of the plethora of interacting elements regulating neoneurogenesis. The present work is a first attempt to model the neurobiological aspect of cancer development through a system of differential equations. The model confirms the experimental observations that a tumour is able to promote nerve formation/elongation around itself, and that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of a tumour. Our results also reflect the observation that high stress levels (represented by higher norepinephrine release by sympathetic nerves) contribute to tumour development and spread, indicating a mutually beneficial relationship between tumour cells and neurons. The model predictions suggest novel therapeutic strategies, aimed at blocking the stress effects on tumour growth and dissemination.. null, 6.
Center for Information Services and High Performance Computing, Q1 Technische Universität Dresden, 01062 Dresden, Germany.jm2187@cam.ac.ukUniversity of CambridgeBIOMD0000000750It is well-known that tumours induce the formation of a lymphatic and a blood vasculature around themselves. A similar but far less studied process occurs in relation to the nervous system and is referred to as neoneurogenesis. The relationship between tumour progression and the nervous system is still poorly understood and is likely to involve a multitude of factors. It is therefore relevant to study tumour-nerve interactions through mathematical modelling: this may reveal the most significant factors of the plethora of interacting elements regulating neoneurogenesis. The present work is a first attempt to model the neurobiological aspect of cancer development through a system of differential equations. The model confirms the experimental observations that a tumour is able to promote nerve formation/elongation around itself, and that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of a tumour. Our results also reflect the observation that high stress levels (represented by higher norepinephrine release by sympathetic nerves) contribute to tumour development and spread, indicating a mutually beneficial relationship between tumour cells and neurons. The model predictions suggest novel therapeutic strategies, aimed at blocking the stress effects on tumour growth and dissemination.Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach.Lolas Georgios G, Bianchi Arianna A, Syrigos Konstantinos N KNtumour disease, development, neoplastic growth, postnatal development., growth pattern, cell process disease, tumor disease, non-developmental growth, neoplasia, neoplasm (disease), postnatal growth, neoplastic disease, tumor, tumour, growth and development, other neoplasm, neoplasm, growth, disease of cellular proliferationprojections, malignant Growth, (+, Nervensystem, postnatal development., single-organism developmental process, Nerve growth factor, experimental, lamellae, -)-Isomer, Nerve Growth Factor 1, neoplasia, Neoplasms, cell type cancer, Nerve Growth Factor alpha Subunit, Nerve, Nerve Growth Factor gamma Subunit, number, Levarterenol, Monohydrate, growth and development, biosynthesis, Tumor, Levonor, process of organ, neurological system, body system, presence, Noradrenaline, NEOPL, element, protrusion, Levonorepinephrine, lamella, blood vessels, Nervous Systems, 1, system, neoplasm, malignant tumour, multicellular organismal biosynthetic process, Norepinephrine Bitartrate, study, single-organism biosynthetic process, anatomical systems, methods, Pathfinding, formation, cell process disease, tumor disease, anabolism, experimental section, neoplasm (disease), nerves, Neuronal Pathfinding, 2-Benzenediol, tumour, present in organism, ridges, W, Norepinephrine d-Tartrate (1:1), CA, synthesis, Neuronal Guidance, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), systema nervosum, Axon, malignant neoplasm, papilla, Norepinephrine l-Tartrate, NGF-1beta, Neuron, tumor, Norepinephrin d-Tartrate (1:1), elements, laminae, Nerve Cell, Neoplastic Growth, atom, Tumors, Axonal Pathfinding, blood vessel system, malignancy, Nerve Growth Factor beta Subunit, Axon Pathfinding, 4-(2-amino-1-hydroxyethyl)-, anatomical protrusion, Neural Guidance, malignant, anatomical process, Noradrénaline tartrate renaudin, lamina, flanges, neoplastic disease, Factor, isoform CRA_b, tumours, blood vascular network, results, Cell, development, count in organism, Noradrenaline Bitartrate, neoplastic growth, peripheral nerve, MT, Neural Pathfinding, NGF, malignant neoplasm (disease), Systems, shelf, organ system cancer, Norepinephrine l-Tartrate (1:2), atomo, atomus, axon pathfinding, Neurite Guidance, connected anatomical system, atome, flange, organ process, Arterenol, primary cancer, nerve net, Element, Nerve Cells, growth pattern, non-developmental growth, shelves, System, blood system, atoms, Norepinephrine l-Tartrate (1:1), postnatal growth, NGF 1beta, Levophed Bitartrate, axon growth cone guidance, disease of cellular proliferation, projection, Norepinephrine Hydrochloride, ridge, malignant tumor, (R)-, beta, experimental procedures, organ system, tumour disease, processes, process, (+)-Isomer, set of blood vessels, spine, malignant neoplastic disease, Cells, Nervous, neural subtree, beta Nerve Growth Factor, processus, Levophed, beta-Nerve Growth, quantitative, other neoplasm, cancer, Norepinephrine, growth, NEOPLASMS BENIGN, Neoplasia, axon chemotaxis, beta-Nerve Growth Factor, presence or absence in organismprojections, extent, malignant Growth, (+, Sectors, Public Sectors, Nervensystem, single-organism developmental process, Nerve growth factor, experimental, lamellae, -)-Isomer, Nerve Growth Factor 1, neoplasia, Neoplasms, cell type cancer, postnatal development, Nerve Growth Factor alpha Subunit, Nerve, Nerve Growth Factor gamma Subunit, number, Levarterenol, Monohydrate, growth and development, Copyrights, biosynthesis, Tumor, Levonor, process of organ, neurological system, body system, presence, Noradrenaline, NEOPL, element, protrusion, Levonorepinephrine, lamella, blood vessels, Nervous Systems, 1, system, Public Enterprise, neoplasm, Enterprises, malignant tumour, multicellular organismal biosynthetic process, Norepinephrine Bitartrate, study, single-organism biosynthetic process, anatomical systems, methods, Pathfinding, formation, cell process disease, tumor disease, anabolism, experimental section, neoplasm (disease), nerves, Neuronal Pathfinding, Public Domains, 2-Benzenediol, tumour, present in organism, ridges, W, Norepinephrine d-Tartrate (1:1), Public Enterprises, CA, synthesis, Neuronal Guidance, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), systema nervosum, Abstract, Axon, malignant neoplasm, papilla, Norepinephrine l-Tartrate, NGF-1beta, Neuron, tumor, Norepinephrin d-Tartrate (1:1), elements, Enterprise, laminae, Nerve Cell, Neoplastic Growth, atom, Tumors, Axonal Pathfinding, blood vessel system, malignancy, Nerve Growth Factor beta Subunit, Axon Pathfinding, 4-(2-amino-1-hydroxyethyl)-, anatomical protrusion, Papers, Neural Guidance, completeness, malignant, anatomical process, Noradrénaline tartrate renaudin, lamina, flanges, neoplastic disease, Factor, isoform CRA_b, tumours, blood vascular network, results, Cell, development, count in organism, Noradrenaline Bitartrate, neoplastic growth, peripheral nerve, MT, Neural Pathfinding, Public, Public Domain, NGF, malignant neoplasm (disease), Systems, shelf, organ system cancer, Norepinephrine l-Tartrate (1:2), Domains, atomo, atomus, axon pathfinding, Neurite Guidance, connected anatomical system, atome, flange, Domain, organ process, Data Base, Arterenol, primary cancer, nerve net, Element, Nerve Cells, growth pattern, non-developmental growth, shelves, System, blood system, atoms, postnatal growth, Norepinephrine l-Tartrate (1:1), NGF 1beta, Levophed Bitartrate, axon growth cone guidance, disease of cellular proliferation, projection, Norepinephrine Hydrochloride, ridge, malignant tumor, (R)-, beta, experimental procedures, organ system, tumour disease, processes, process, Sector, (+)-Isomer, set of blood vessels, spine, malignant neoplastic disease, Cells, Nervous, neural subtree, beta Nerve Growth Factor, processus, Levophed, Public., beta-Nerve Growth, quantitative, other neoplasm, growth, cancer, Norepinephrine, NEOPLASMS BENIGN, Neoplasia, axon chemotaxis, beta-Nerve Growth Factor, presence or absence in organismtumour disease, development, neoplastic growth, postnatal development., growth pattern, cell process disease, tumor disease, non-developmental growth, neoplasia, neoplasm (disease), postnatal growth, neoplastic disease, tumor, tumour, growth and development, other neoplasm, neoplasm, growth, disease of cellular proliferationfalseLolas2016 - tumour-induced neoneurogenesis and perineural tumour growthThe paper describes a model of tumour-induced neoneurogenesis and perineural tumour growth.
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This model is described in the article:
Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach
Georgios Lolas, Arianna Bianchi and Konstantinos N. Syrigos
Scientific Reports 6:20684
Abstract:
It is well-known that tumours induce the formation of a lymphatic and a blood vasculature around themselves. A similar but far less studied process occurs in relation to the nervous system and is referred to as neoneurogenesis. The relationship between tumour progression and the nervous system is still poorly understood and is likely to involve a multitude of factors. It is therefore relevant to study tumour-nerve interactions through mathematical modelling: this may reveal the most significant factors of the plethora of interacting elements regulating neoneurogenesis. The present work is a first attempt to model the neurobiological aspect of cancer development through a system of differential equations. The model confirms the experimental observations that a tumour is able to promote nerve formation/elongation around itself, and that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of a tumour. Our results also reflect the observation that high stress levels (represented by higher norepinephrine release by sympathetic nerves) contribute to tumour development and spread, indicating a mutually beneficial relationship between tumour cells and neurons. The model predictions suggest novel therapeutic strategies, aimed at blocking the stress effects on tumour growth and dissemination.
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Please refer to CC0 Public Domain Dedication for more information.2019-07-162019-07-162019-07-16BIOMD0000000750SBO:0000610SBO:0000661SBO:0000393SBO:0000179SBO:0000185SBO:000058726861829C94498C48228C19365C48260C20424C67363C53346C25636C44175CHEBI:33569CHEBI:15355MODEL1907160001BIOMD0000000750GO:0022008GO:0007411GO:0008283GO:0008219GO:0016477GO:0023061GO:0098657CL:0001063CL:0011103CL:00111029606