BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000797?filename=Hu2018.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000797?filename=Hu2018.sedmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000797?filename=Hu2018.cpsprimaryOK200Johannes MeyerManually curatedordinary differential equation modelL2V4Immuno-oncologyhttps://www.ebi.ac.uk/biomodels/BIOMD0000000797falseBioModelsModelsSBMLHu2018 Dynamics of tumor CD4+ cytokine host cells interactions with treatments2018MODEL1908150001Hu, X.Hu, X., Jang, S.R.-J.10.1016/j.amc.2017.11.009,
Mathematical models of interactions between tumor cells, CD4+ T cells, cytokines, and host cells are proposed to investigate the role of CD4+ on tumor regression. Our results suggest that host cells along with the mechanism of production of CD4+ T cells play important roles in driving tumor dynamics. Cancer cells can be eradicated if the tumor has a small growth rate and is also not competitive. Treatments by either CD4+, cytokines, or a combination of the two are applied to study their effectiveness. It is concluded that doses of treatments along with the tumor size are critical in determining the fate of the tumor. Tumor cells can be eliminated completely if doses of treatments by cytokine are large. The treatments are in general more effective if the tumor size is smaller. Bistability is observed in all of the models with or without the treatment strategies indicating that there is a window of opportunity for clearing off the tumor cells.. null, 321.
Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX 79409-1042, United Statesjohannes.p.meyer@gmail.com10.1016/j.amc.2017.11.009EMBL-EBIBIOMD0000000797Therapy, host organism, L3T4, Cytokine, T-cell surface antigen T4/Leu-3, Therapeutic, T-cell differentiation antigen L3T4, T-cell surface antigen T4|Leu-3, T-cell surface glycoprotein CD4, Ly-4, Therapies, CD4, Treatment, CD4mut, Treatments., Tumor, Celltreatment, Cytokine., host organism, L3T4, Cytokine, T-cell surface antigen T4/Leu-3, T-cell differentiation antigen L3T4, T-cell surface antigen T4|Leu-3, T-cell surface glycoprotein CD4, disease management, Ly-4, CD4, CD4mut, Tumor, CellfalseHu2018 - Dynamics of tumor-CD4+-cytokine-host cells interactions with treatments
This is a proposed mathematical model describing interactions between tumor cells, CD4+ T cells, cytokines, and host cells within the context of CD4+ T cells inducing tumor regression. A platform is provided to assess the effectiveness of single or combination therapy with CD4+ T cells and/or cytokines.
2021-10-052021-10-052019-08-15BIOMD0000000797SBO:0000179C94498C20464C12801C18081C15351C15411MODEL1908150001BIOMD0000000797GO:0002418GO:0008219GO:0035212GO:0001816CL:0001063CL:0000492Q0GK4310.1016/j.amc.2017.11.00910.1002/mma.3370