BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000958?filename=Ndairou2020.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000958?filename=Ndairou2020.sedmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000958?filename=Ndairou2020.omexhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000958?filename=Ndairou2020.cpsprimaryOK200Kausthubh Ramachandranpopulation modelManually curatedCovid-19COVID-19L2V4https://www.ebi.ac.uk/biomodels/BIOMD0000000958falseBioModelsSBMLModelsNdairou2020 early stage transmission dynamics of COVID 19 in Wuhan2020MODEL2008140001Ndaïrou F, Area I, Nieto JJ, Torres DFNdaïrou F32341628, We propose a compartmental mathematical model for the spread of the COVID-19 disease with special focus on the transmissibility of super-spreaders individuals. We compute the basic reproduction number threshold, we study the local stability of the disease free equilibrium in terms of the basic reproduction number, and we investigate the sensitivity of the model with respect to the variation of each one of its parameters. Numerical simulations show the suitability of the proposed COVID-19 model for the outbreak that occurred in Wuhan, China.. , . Center for Research and Development in Mathematics and Applications (CIDMA), Department of Mathematics, University of Aveiro, Aveiro 3810-193, Portugal.rkausthubh@gmail.comEMBL-EBIBIOMD0000000958We propose a compartmental mathematical model for the spread of the COVID-19 disease with special focus on the transmissibility of super-spreaders individuals. We compute the basic reproduction number threshold, we study the local stability of the disease free equilibrium in terms of the basic reproduction number, and we investigate the sensitivity of the model with respect to the variation of each one of its parameters. Numerical simulations show the suitability of the proposed COVID-19 model for the outbreak that occurred in Wuhan, China.Mathematical modeling of COVID-19 transmission dynamics with a case study of Wuhan.Ndaïrou Faïçal F, Area Iván I, Nieto Juan J JJ, Torres Delfim F M DFMCOVID19, other disease, Respect, COVID-19, Virus Infection, 2019 novel coronavirus, COVID-19 Virus Diseases, Virus Disease, Reproductive Rate, 2019 nCoV Disease, Personal, Rate, diseases, sensitive, 2019-nCoV Disease, Basic Reproductive Number, SARS CoV 2 Infection, Severe Acute Respiratory Syndrome Coronavirus 2 Infection, disease or disorder, Basic Reproduction Ratio, diseases and disorders, β-coronavirus, coronavirus disease 2019, 2019-nCoV, COVID 19 Pandemic, sensitivity, Transmissibility Measures, study, human disease, β-CoVs, FOCUS, COVID-19 Virus Infection, Coronavirus Disease 2019, Basic Reproductive Ratio, severe acute respiratory syndrome coronavirus 2, Coronavirus Disease-19, beta-CoVs, SARS-CoV-2 Infection, free, CoV-2 infection, non-neoplastic, allergic reaction, Reproductive Ratio, Reproduction Ratio, COVID-19 Virus, Effective Reproduction Numbers, Personal Respect, Effective, disorder, Homo sapiens disease, hypersensitivity reaction, Transmissibility Measure, COVID 19 Virus Disease, SARS Coronavirus 2 Infection, R0 Basic Reproduction Number, RE Effective Reproduction Number, 2019-nCoV Infections, Disease, Reproductive Number, Coronavirus Disease 19, β-CoV, beta-CoV, disorders, SARS-CoV-2, medical condition, 2019 Novel Coronavirus Disease, SARS-CoV-2 Infections, 2019 nCoV Infection, COVID 19 Virus Infection, People's Republic of China, COVID-19 Virus Disease, Effective Reproductive Numbers, Manchuria, 2019-nCoV Infection, Inner Mongolia, Basic Reproductive Rates, Basic Reproductive, Sinkiang., Diseases, Infection, condition, Coronavirus, COVID-19 Virus Infections, Basic Reproductive Rate, severe acute respiratory syndrome coronavirus 2 infectious disease, Basic, 2019 novel coronavirus infection, hypersensitivity, hypersensitive, betacoronavirus, Disease 2019, Reproduction Number, Mainland China, Pandemic, Dignity, COVID-19 Pandemics, COVID-19 Pandemic, SARS-coronavirus 2, Re Effective Reproductive Number, disease, Effective Reproductive Number, Effective Reproduction Number, Reproductive Rates, Basic Reproductive Ratios, hypersensitivity reaction disease, 2019 Novel Coronavirus Infection, 2019-nCoV infection, 2019-nCoV Diseases, Basic Reproductive Numbers, COVID 19COVID19, Disease, advanced, Coronavirus Disease 19, β-CoV, beta-CoV, developmental stage, COVID-19, 2019-nCoV Infections., SARS-CoV-2, Virus Infection, 2019 novel coronavirus, COVID-19 Virus Diseases, 2019 Novel Coronavirus Disease, SARS-CoV-2 Infections, 2019 nCoV Infection, COVID 19 Virus Infection, Virus Disease, 2019 nCoV Disease, Fs(3)Sz11, COVID-19 Virus Disease, 2019-nCoV Infection, 2019-nCoV Disease, SARS CoV 2 Infection, precocious, Infection, Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Coronavirus, DmF2, β-coronavirus, coronavirus disease 2019, COVID-19 Virus Infections, Fs(3)Hor, 2019-nCoV, COVID 19 Pandemic, severe acute respiratory syndrome coronavirus 2 infectious disease, lod, 2019 novel coronavirus infection, DmelCG2684, β-CoVs, betacoronavirus, Disease 2019, Pandemic, COVID-19 Virus Infection, Coronavirus Disease 2019, severe acute respiratory syndrome coronavirus 2, Coronavirus Disease-19, NTef2, Lds, beta-CoVs, COVID-19 Pandemics, SARS-CoV-2 Infection, COVID-19 Pandemic, CoV-2 infection, early, SARS-coronavirus 2, COVID-19 Virus, Horka, CG2684, Fs(3)Horka, 2019 Novel Coronavirus Infection, stage, 2019-nCoV infection, 2019-nCoV Diseases, COVID 19 Virus Disease, SARS Coronavirus 2 Infection, COVID 19COVID19, Disease, Coronavirus Disease 19, β-CoV, beta-CoV, Math, COVID-19, SARS-CoV-2, Virus Infection, 2019 novel coronavirus, COVID-19 Virus Diseases, 2019 Novel Coronavirus Disease, SARS-CoV-2 Infections, 2019 nCoV Infection, COVID 19 Virus Infection, Virus Disease, 2019 nCoV Disease, Wuhan., COVID-19 Virus Disease, 2019-nCoV Infection, 2019-nCoV Disease, SARS CoV 2 Infection, Infection, Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Coronavirus, β-coronavirus, coronavirus disease 2019, COVID-19 Virus Infections, Case Studies, 2019-nCoV, COVID 19 Pandemic, severe acute respiratory syndrome coronavirus 2 infectious disease, 2019 novel coronavirus infection, β-CoVs, betacoronavirus, Disease 2019, Pandemic, Mathematics, Modeling, COVID-19 Virus Infection, Coronavirus Disease 2019, severe acute respiratory syndrome coronavirus 2, Coronavirus Disease-19, beta-CoVs, COVID-19 Pandemics, SARS-CoV-2 Infection, COVID-19 Pandemic, CoV-2 infection, SARS-coronavirus 2, Case Study, COVID-19 Virus, Mathematical, Case Histories, 2019 Novel Coronavirus Infection, 2019-nCoV infection, 2019-nCoV Diseases, COVID 19 Virus Disease, SARS Coronavirus 2 Infection, COVID 19, 2019-nCoV InfectionsTake Place, COVID19, other disease, Respect, Experimental Models, Theoretical Model, COVID-19, Numeric, number, Virus Infection, 2019 novel coronavirus, COVID-19 Virus Diseases, Special, LOCAL, Virus Disease, Reproductive Rate, Theoretical, 2019 nCoV Disease, Mathematical Models, aa, Personal, Rate, Disease Free, SMEAR, diseases, Local, Happen, sensitive, 2019-nCoV Disease, Basic Reproductive Number, SARS CoV 2 Infection, Studies, Variant, Severe Acute Respiratory Syndrome Coronavirus 2 Infection, disease or disorder, Basic Reproduction Ratio, Experimental Model, diseases and disorders, β-coronavirus, coronavirus disease 2019, Models, 2019-nCoV, COVID 19 Pandemic, Local-Regional, sensitivity, Transmissibility Measures, study, Numerical, human disease, β-CoVs, Theoretical Study, FOCUS, Occur, COVID-19 Virus Infection, Coronavirus Disease 2019, Basic Reproductive Ratio, Of Each, severe acute respiratory syndrome coronavirus 2, Coronavirus Disease-19, Smear, Theoretic, beta-CoVs, SARS-CoV-2 Infection, CoV-2 infection, Occurred, non-neoplastic, Study, allergic reaction, Reproductive Ratio, Reproduction Ratio, COVID-19 Virus, Happened, LOCOREGIONAL, Mathematical, Effective Reproduction Numbers, Personal Respect, Effective, Disease-Free Survival, disorder, {Number}, Homo sapiens disease, hypersensitivity reaction, Spreading, Model, Transmissibility Measure, COVID 19 Virus Disease, SARS Coronavirus 2 Infection, R0 Basic Reproduction Number, RE Effective Reproduction Number, Variation, 2019-nCoV Infections, Disease-free, Disease, Reproductive Number, Coronavirus Disease 19, β-CoV, beta-CoV, Regional, disorders, Spread, SARS-CoV-2, Model (Theoretical), medical condition, 2019 Novel Coronavirus Disease, SARS-CoV-2 Infections, 2019 nCoV Infection, COVID 19 Virus Infection, People's Republic of China, COVID-19 Virus Disease, Effective Reproductive Numbers, Manchuria, 2019-nCoV Infection, Inner Mongolia, Experimental, Basic Reproductive Rates, Basic Reproductive, Theoretical Studies, Sinkiang., Diseases, Infection, condition, Coronavirus, disease-free survival, Ana, COVID-19 Virus Infections, Basic Reproductive Rate, Deviation, severe acute respiratory syndrome coronavirus 2 infectious disease, Basic, 2019 novel coronavirus infection, hypersensitivity, hypersensitive, VARIATION, betacoronavirus, Disease 2019, Reproduction Number, Mainland China, Pandemic, Dignity, Number, Wuhan, COVID-19 Pandemics, COVID-19 Pandemic, SARS-coronavirus 2, Theoretical Models, Re Effective Reproductive Number, disease, Effective Reproductive Number, Models (Theoretical), Effective Reproduction Number, Took Place, Reproductive Rates, Basic Reproductive Ratios, hypersensitivity reaction disease, 2019 Novel Coronavirus Infection, Localized Disease, 2019-nCoV infection, 2019-nCoV Diseases, Basic Reproductive Numbers, Mathematical Model, COVID 19falseNdairou2020 - early-stage transmission dynamics of COVID-19 in WuhanWe propose a compartmental mathematical model for the spread of the COVID-19 disease with special focus on the transmissibility of super-spreaders individuals. We compute the basic reproduction number threshold, we study the local stability of the disease free equilibrium in terms of the basic reproduction number, and we investigate the sensitivity of the model with respect to the variation of each one of its parameters. Numerical simulations show the suitability of the proposed COVID-19 model for the outbreak that occurred in Wuhan, China2021-07-142021-07-142020-08-14BIOMD0000000958BIOMD0000000958MODEL200814000132341628C171133C25746C16428C25632C1715490000511C49508C25179C28554C128320C2522726970499606