BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000967?filename=McLean1991.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000967?filename=McLean1991.omexhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000967?filename=McLean1991.sedmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000967?filename=McLean1991.cpsprimaryOK200Sathvik AnantakrishnanManually curatedordinary differential equation modelL3V1https://www.ebi.ac.uk/biomodels/BIOMD00000009671677807falseBioModelsSBMLModelsMcLean1991 Behaviour of HIV in the presence of zidovudine1991MODEL1912050003McLean AR, Emery VC, Webster A, Griffiths PDMcLean AR1677807,
A new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). Using a simple mathematical model of the interacting population dynamics of HIV and its major host cell in the circulation (the CD4+ lymphocyte), predicted patterns of HIV plasma viraemia in the weeks following treatment with zidovudine are generated. These are in close agreement with observed patterns despite the fact that the model contains no mechanisms for the development of drug-resistant strains of virus. It is suggested that the patterns of viral abundance observed during the first 6 months after treatment may be the result of non-linearities in the interactions between HIV and CD4+ cells, and that it is only after the first post-treatment burst of viral production that drug resistance plays an important role.. 5, 5.
Laboratory of Mathematical Biology, National Institute for Medical Research, Mill Hill, UK.sathvikanantakrishnan@smail.iitm.ac.inIndian Institute of Technology MadrasBIOMD0000000967A new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). Using a simple mathematical model of the interacting population dynamics of HIV and its major host cell in the circulation (the CD4+ lymphocyte), predicted patterns of HIV plasma viraemia in the weeks following treatment with zidovudine are generated. These are in close agreement with observed patterns despite the fact that the model contains no mechanisms for the development of drug-resistant strains of virus. It is suggested that the patterns of viral abundance observed during the first 6 months after treatment may be the result of non-linearities in the interactions between HIV and CD4+ cells, and that it is only after the first post-treatment burst of viral production that drug resistance plays an important role.Population dynamics of HIV within an individual after treatment with zidovudine.McLean A R AR, Emery V C VC, Webster A A, Griffiths P D PDRetrovir, Human T-Cell Lymphotropic Virus Type III, Human Immunodeficiency Virus, Human T Lymphotropic Virus Type III, Thymidine, number, AIDS Virus, HTLV-III, Azidothymidine, 3' Azido 2', Antiviral, presence, Human Immunodeficiency, Human, Lymphadenopathy Associated Virus, 3'-Dideoxythymidine, count in organism, AIDS, Immunodeficiency Virus, Antiviral AZT, Virus, Human T-Cell Leukemia Virus Type III, BWA 509U, AZT, AIDS virus, Acquired Immune Deficiency Syndrome Virus, 3'-azido-3'-deoxy-, Human T-Lymphotropic Virus Type III, Lymphadenopathy-Associated, Viruses, AIDS Viruses, 3' Azido 3' deoxythymidine, Immunodeficiency Viruses, behavioral response to stimulus, AZT (Antiviral)., 3'-Azido-3'-deoxythymidine, Human T Cell Leukemia Virus Type III, LAV-HTLV-III, BWA509U, BW A509U, AZT Antiviral, behavioural response to stimulus, 3'-Azido-2', Acquired Immunodeficiency Syndrome Virus, Lymphadenopathy-Associated Viruses, BWA-509U, 3' Dideoxythymidine, HIV, quantitative, Human Immunodeficiency Viruses, behaviour, Human T Cell Lymphotropic Virus Type III, single-organism behavior, Lymphadenopathy-Associated Virus, presence or absence in organismFresh, Rural-Urban Migrations, Human T-Cell Lymphotropic Virus Type III, Mobilities, Stable Populations, Residential, Transitions, Migration, Demographic Transitions, Mobility, T-cell surface antigen T4/Leu-3, insensitive, Fresh Frozen Plasma, single-organism developmental process, Stable Population, Blood, drug susceptibility/resistance, AIDS Virus, HTLV-III, Azidothymidine, Rural-Urban, 3' Azido 2', Aging, Antiviral, Population Theories, Population Decreases, Human Immunodeficiency, Human, Lymphadenopathy Associated Virus, L3T4, Decreases, Stationary, Population Pressures, Roles, Antiviral AZT, Virus, Ly-4, Concepts, Population Replacement, Human T-Cell Leukemia Virus Type III, Role Concepts., BWA 509U, Sprains, AZT, drug resistance, Neomalthusianism, treatment, FACT80, 3'-azido-3'-deoxy-, Fresh Frozen Plasmas, Fresh Frozen, Human T-Lymphotropic Virus Type III, Blood Plasma, Theory, Viruses, 3' Azido 3' deoxythymidine, FACT, Immunodeficiency Viruses, Population, Human T Cell Leukemia Virus Type III, Malthusianism, Population Theory, drugs, Stable, medicine, 3'-Azido-2', Blood Plasmas, disease management, Optimum, Lymphadenopathy-Associated Viruses, BWA-509U, 3' Dideoxythymidine, Optimum Population, HIV, Strains, Theories, Human Immunodeficiency Viruses, Transition, SIMPLE, plasma, Lymphadenopathy-Associated Virus, TP53I7, Retrovir, Human Immunodeficiency Virus, Frozen Plasma, Human T Lymphotropic Virus Type III, Thymidine, T-cell surface antigen T4|Leu-3, Drug resistance, drug, Stationary Populations, Sprain, Plasmas, Cell, predicted, Demographic Transition, Concept, Frozen Plasmas, development, 3'-Dideoxythymidine, Role Concept, AIDS, T-cell differentiation antigen L3T4, Immunodeficiency Virus, PIG7, Pressure, Strain, Resistance, Role, Demographic, Population Decrease, Decrease, Optimum Populations, burst, AIDS virus, Population Replacements, Acquired Immune Deficiency Syndrome Virus, Plasma, Populations, Replacements, portion of blood plasma, Lymphadenopathy-Associated, Rural Urban Migration, AIDS Viruses, resistant, Residential Mobility, T-cell surface glycoprotein CD4, response to drug, Residential Mobilities, Stationary Population, portion of plasma, Dynamics, CD4mut, Rural-Urban Migration, 3'-Azido-3'-deoxythymidine, LAV-HTLV-III, BWA509U, BW A509U, AZT (Antiviral), AZT Antiviral, Drug, blood plasm, Migrations, Population Pressure, Pressures, Replacement, Acquired Immunodeficiency Syndrome Virus, Demographic Aging, T160, CD4, Strains and Sprains, Human T Cell Lymphotropic Virus Type IIIFresh, Rural-Urban Migrations, Human T-Cell Lymphotropic Virus Type III, Mobilities, Stable Populations, Residential, Transitions, Migration, Demographic Transitions, Mobility, T-cell surface antigen T4/Leu-3, insensitive, Fresh Frozen Plasma, single-organism developmental process, Stable Population, Blood, drug susceptibility/resistance, AIDS Virus, HTLV-III, Azidothymidine, Rural-Urban, 3' Azido 2', Aging, Antiviral, Population Theories, Population Decreases, Human Immunodeficiency, Human, Lymphadenopathy Associated Virus, L3T4, Decreases, Stationary, Population Pressures, Roles, Antiviral AZT, Virus, Ly-4, Concepts, Population Replacement, Human T-Cell Leukemia Virus Type III, Role Concepts., BWA 509U, Sprains, AZT, drug resistance, Neomalthusianism, treatment, FACT80, 3'-azido-3'-deoxy-, Fresh Frozen Plasmas, Fresh Frozen, Human T-Lymphotropic Virus Type III, Blood Plasma, Theory, Viruses, 3' Azido 3' deoxythymidine, FACT, Immunodeficiency Viruses, Population, Human T Cell Leukemia Virus Type III, Malthusianism, Population Theory, drugs, Stable, medicine, 3'-Azido-2', Blood Plasmas, disease management, Optimum, Lymphadenopathy-Associated Viruses, BWA-509U, 3' Dideoxythymidine, Optimum Population, HIV, Strains, Theories, Human Immunodeficiency Viruses, Transition, SIMPLE, plasma, Lymphadenopathy-Associated Virus, TP53I7, Retrovir, Human Immunodeficiency Virus, Frozen Plasma, Human T Lymphotropic Virus Type III, Thymidine, T-cell surface antigen T4|Leu-3, Drug resistance, drug, Stationary Populations, Sprain, Plasmas, Cell, predicted, Demographic Transition, Concept, Frozen Plasmas, development, 3'-Dideoxythymidine, Role Concept, AIDS, T-cell differentiation antigen L3T4, Immunodeficiency Virus, PIG7, Pressure, Strain, Resistance, Role, Demographic, Population Decrease, Decrease, Optimum Populations, burst, AIDS virus, Population Replacements, Acquired Immune Deficiency Syndrome Virus, Plasma, Populations, Replacements, portion of blood plasma, Lymphadenopathy-Associated, Rural Urban Migration, AIDS Viruses, resistant, Residential Mobility, T-cell surface glycoprotein CD4, response to drug, Residential Mobilities, Stationary Population, portion of plasma, Dynamics, CD4mut, Rural-Urban Migration, 3'-Azido-3'-deoxythymidine, LAV-HTLV-III, BWA509U, BW A509U, AZT (Antiviral), AZT Antiviral, Drug, blood plasm, Migrations, Population Pressure, Pressures, Replacement, Acquired Immunodeficiency Syndrome Virus, Demographic Aging, T160, CD4, Strains and Sprains, Human T Cell Lymphotropic Virus Type IIIRural-Urban Migrations, Retrovir, Mobilities, Stable Populations, Human T-Cell Lymphotropic Virus Type III, Human Immunodeficiency Virus, Residential, Transitions, Migration, Demographic Transitions, Human T Lymphotropic Virus Type III, Mobility, Thymidine, Stable Population, Stationary Populations, AIDS Virus, HTLV-III, Azidothymidine, Rural-Urban, 3' Azido 2', Aging, Antiviral, Population Theories, Population Decreases, Human Immunodeficiency, Demographic Transition, Human, Lymphadenopathy Associated Virus, 3'-Dideoxythymidine, Decreases, Stationary, Population Pressures, AIDS, Immunodeficiency Virus, Pressure, Antiviral AZT, Virus, Demographic, Population Replacement, Population Decrease, Decrease, Optimum Populations, Human T-Cell Leukemia Virus Type III, BWA 509U, AZT, Neomalthusianism, Population Replacements, AIDS virus, Acquired Immune Deficiency Syndrome Virus, Populations, 3'-azido-3'-deoxy-, Replacements, Human T-Lymphotropic Virus Type III, Theory, Rural Urban Migration, Lymphadenopathy-Associated, Viruses, AIDS Viruses, Residential Mobility, 3' Azido 3' deoxythymidine, Residential Mobilities, Stationary Population, Immunodeficiency Viruses, Dynamics, Rural-Urban Migration, Population, AZT (Antiviral)., 3'-Azido-3'-deoxythymidine, Human T Cell Leukemia Virus Type III, LAV-HTLV-III, BWA509U, BW A509U, AZT Antiviral, Malthusianism, Population Theory, Migrations, Population Pressure, Pressures, Stable, Replacement, 3'-Azido-2', Demographic Aging, Acquired Immunodeficiency Syndrome Virus, Optimum, Lymphadenopathy-Associated Viruses, BWA-509U, 3' Dideoxythymidine, Optimum Population, HIV, Theories, Transition, Human Immunodeficiency Viruses, Human T Cell Lymphotropic Virus Type III, Lymphadenopathy-Associated VirusfalseMcLean1991 - Behaviour of HIV in the presence of zidovudineA new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). Using a simple mathematical model of the interacting population dynamics of HIV and its major host cell in the circulation (the CD4+ lymphocyte), predicted patterns of HIV plasma viraemia in the weeks following treatment with zidovudine are generated. These are in close agreement with observed patterns despite the fact that the model contains no mechanisms for the development of drug-resistant strains of virus. It is suggested that the patterns of viral abundance observed during the first 6 months after treatment may be the result of non-linearities in the interactions between HIV and CD4+ cells, and that it is only after the first post-treatment burst of viral production that drug resistance plays an important role.2020-10-152020-10-152019-12-05BIOMD0000000967SBO:0000022SBO:0000610SBO:00000161677807C3108C16118C12434C49159C94967C88183C160241BIOMD0000000967MODEL1912050003GO:0016265GO:0042093GO:0019076CL:0000912960612721BTO:0002417