BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000968?filename=Palmer2008.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000968?filename=Palmer2008.cpshttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000968?filename=Palmer2008.sedmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000968?filename=Palmer2008.omexprimaryOK200Gladys LangiManually curatedordinary differential equation modelL3V1https://www.ebi.ac.uk/biomodels/BIOMD000000096818445337falseBioModelsSBMLModelsPalmer2008 Negative Feedback in IL 7 mediated Jak Stat signaling2008MODEL2010160001Palmer MJ, Mahajan VS, Trajman LC, Irvine DJ, Lauffenburger DA, Chen JPalmer MJ18445337,
Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.. 2, 5.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.gladys.langi@umb.edu.plBIOMD0000000968Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.Interleukin-7 receptor signaling network: an integrated systems perspective.Palmer Megan J MJ, Mahajan Vinay S VS, Trajman Lily C LC, Irvine Darrell J DJ, Lauffenburger Douglas A DA, Chen Jianzhu JCenters, Networks, Lymphopoietin-1, and Consortia, Interleukin-7, Network Interface, Integrated., Receptor Signaling, IL-7, Consortium or Network, Lymphopoietin 1, Interleukin 7, Network Device, IL7, Network, Consortium, NCI Consortium or Networkhlb368, signalling., DmelCG1594, DmHD-160, A630026I06Rik, biological signaling, Tum-1, Hop1, Il-7, interleukin-7 receptor ligand, jak, l(1)hop, Dm JAK, HOP, L4, Hop, signalling process, l(1)L4, HD-160, signaling process, Tum, Janus kinase activity, IL-7, msvl, l(1)G18, 4, IL7, JAK, Jak, Feedbacks, protein-tyrosine kinase activity, CG1594, l(1)10Be, d-jak, single organism signalinghlb368, Proliferating, Networks, other disease, B Cells, biological signaling, Crosstalk, single-organism developmental process, Much, determination, Cellular Differentiation, Bursa-Dependent Lymphocytes, Shared, P62, Il-7, Consortium or Network, B cell, interleukin-7 receptor ligand, interleukin-7 receptor alpha deficiency, Biochemical Pathway, Network, Discuss, sci, Cell Differentiation, Normalcies, Ximpact, Integrated, Story, regulation of gene product expression, modulate, Readability, Degree, IL-7Ralpha deficiency, diseases, IL-7, Differentiated, HOW, How, disease or disorder, diseases and disorders, Consortium, Level, l(3)j5D5, NCI Consortium or Network, 24B, Normalities, Centers, Multicase, Cross-reaction, average, cell differentiation, B-cell, human disease, l(3)s2612, reference sample, Academic, ligand, proliferating, Interleukin 7, stru, Pathways, Modulation, l(3)S053606, Maintenances, CG10293, Employ, non-neoplastic, Lymphopoietin-1, l(3)j5B5, Usage, Modulated, Use, B lymphocyte, time of survival, signaling process, Network Interface, DmelCG10293, Cross-reactive, disorder, Homo sapiens disease, glucose uptake, Lymphoid, IL7, Differentiation, Including, Cross Reactivity, Comprehensive, Lymphocyte, single organism signaling, Controlled, Individual Health, 0904/17, Controlling, Ligand, Pathway, Lymphocyte Cell Biology., and Consortia, B Lymphocytes, clone 2.39, Essential, Interest, Lymphopoietin 1, Cross Reaction, disorders, medical condition, Metabolic Network, Normalcy, qkr, l(3)S090417, Cell, impact-a, development, Cytokine, survival, Review Literature, SZ1, KH93F, chemical analysis, Common, Diseases, condition, Lymphoid Cell, gene regulation, T-B+ SCID due to IL-7Ralpha deficiency, Individual, Approach, Modulating, Discussion, Lymphoid Cells, who, IL-7R, differentiation, A630026I06Rik, IL-7 receptor activity, Review, Normality, Interleukin-7, Receptor Signaling, Lymphocyte Biology, Cell Differentiation Process, Network Device, SHARED, Bursa-Equivalent Lymphocyte, Who/How, Understanding, signalling, regulation of protein expression, Floor, disease, Health, signalling process, B-Lymphocyte, Proliferation, Cells, qkr[93F], anon-EST:Liang-2.39, Inclusive, assay, Review of Reported Cases, Feedbacks, B-lymphocyte, molecular pathway, E430016J11Rik, RWDD5hlb368, signalling., Individual Health, other disease, Controlling, biological signaling, Ligand, single-organism developmental process, determination, Il-7, Lymphopoietin 1, disorders, interleukin-7 receptor ligand, interleukin-7 receptor alpha deficiency, medical condition, Normalcy, Normalcies, Ximpact, Cell, impact-a, development, Readability, Cytokine, survival, Review Literature, IL-7Ralpha deficiency, diseases, chemical analysis, IL-7, Diseases, disease or disorder, condition, diseases and disorders, Lymphoid Cell, T-B+ SCID due to IL-7Ralpha deficiency, Individual, Lymphoid Cells, Normalities, Multicase, average, IL-7R, A630026I06Rik, human disease, reference sample, IL-7 receptor activity, Review, Academic, Normality, Interleukin-7, ligand, Interleukin 7, INSDC_feature:gene, Understanding, Maintenances, signalling, non-neoplastic, Lymphopoietin-1, disease, Health, signalling process, time of survival, signaling process, Cells, disorder, Homo sapiens disease, Lymphoid, glucose uptake, regulation, IL7, assay, Review of Reported Cases, Feedbacks, E430016J11Rik, RWDD5, Lymphocyte, single organism signaling, ControlledfalsePalmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signalingInterleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene
regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.2020-10-162020-10-162020-10-16BIOMD0000000968SBO:0000526SBO:0000216SBO:000058918445337C39128BIOMD0000000968MODEL2010160001GO:00506709606BTO:0000775P13232P23458P51692P42229O15524P16871P31785