BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=timecourse1.tellurium.tsvhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=timecourse1.amici.tsvhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=timecourse1.copasi.tsvhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=1-log-hits-stats-spider.tsvhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=1-log-hits-spider.tsvhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=timecourse1.vcell.tsvhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=manifest.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=vonDassow2000_1x4.timecourse1.xmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=Fig2.pnghttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=vonDassow2000_1x4_timecourse1.vcmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=vonDassow2000_1x4_alt.cpshttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=vonDassow2000_1x4.timecourse1.sedmlhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=vonDassow2000_1x4.timecourse1.cpshttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=metadata.rdfhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=runTellurium.pyhttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=timecourse1.plthttps://www.ebi.ac.uk/biomodels/model/download/BIOMD0000001065?filename=param_radial.pltprimaryOK200Pedro MendesManually curatedordinary differential equation modelL3V1https://www.ebi.ac.uk/biomodels/BIOMD0000001065falseBioModelsSBMLModelsvonDassow2000 Segment Polarity Network model on 1x4 grid of cells2000MODEL2304060001G. von Dassow, E. Meir, E. M. Munro, G. M. OdellG. von Dassow10.1038/35018085, All insects possess homologous segments, but segment specification differs radically among insect orders. In Drosophila, maternal morphogens control the patterned activation of gap genes, which encode transcriptional regulators that shape the patterned expression of pair-rule genes. This patterning cascade takes place before cellularization. Pair-rule gene products subsequently 'imprint' segment polarity genes with reiterated patterns, thus defining the primordial segments. This mechanism must be greatly modified in insect groups in which many segments emerge only after cellularization. In beetles and parasitic wasps, for instance, pair-rule homologues are expressed in patterns consistent with roles during segmentation, but these patterns emerge within cellular fields. In contrast, although in locusts pair-rule homologues may not control segmentation, some segment polarity genes and their interactions are conserved. Perhaps segmentation is modular, with each module autonomously expressing a characteristic intrinsic behaviour in response to transient stimuli. If so, evolution could rearrange inputs to modules without changing their intrinsic behaviours. Here we suggest, using computer simulations, that the Drosophila segment polarity genes constitute such a module, and that this module is resistant to variations in the kinetic constants that govern its behaviour.. 6792, 406. University of Washington, Department of Zoology, Box 351800, Seattle, Washington 98195-1800, USApmendes@uchc.edu10.1038/35018085UConn HealthBIOMD0000001065Arp87c, GrpL, GRPL, GADS, ARP1, Mona, GRAP2, ARP87C, segment, Actr87C, GRB2L, arp1, Arp87C, GrbX, serial element, GRID, Gads, CG6174, Arp-1, Grf40, segment - adult, gdl, Cell., P38, GRAP-2, grid, GRBLG, Arp, DmelCG6174Engrailed/Invected, xshh, dTAF[[II]]230, TAF[[II]]250, d230, ptc1, Materials, CG9015, Erinaceidae, Engrailed, protein complex, Proteins, TAF200, l(3)84Ab, Gene, dTAFII250, segment, BG:DS00004.13, protein, TAFII-250, TAF250/230, protein-containing complex, EfW1, Cistrons, DmelCG9015, Cell, dTAF230, dmTAF[[II]]230, TAFII250, serial element, EnR, native protein, EN, en1, dmTAF1, Taf230, p230, Protein, 153867_at, Gene Products, TAF[[II]]250/230, TFIID, Genetic Materials, Hedgehog, Cell., hedgehog, spt, patched, protein aggregate, spa2, Genetic Material, Ptc-1, TAF250, Eng, Taf[[II]]250, Taf200, dTAF[[II]]250, TAF[[II]]230, Genetic, TFIID TAF250, En, cel, cell, Es, XPtc1, Taf1p, Engr, TAF[II]250, V, Xhh, CG17603, TAF[[II]], Protein Gene Products, dTAF250, Gene Proteins, DmelCG17603, Taf250, Material, SR3-5, segment - adult, microarray, Cistron, Apa, TAF, patched1, TAF230, TAF1falsevonDassow2000 - Segment Polarity Network model on 1x4 grid of cellsThis is the segment polarity network model described by von Dassow et al. (2000). It represents a toroidal hexagonal array of cells (1x4), where each cell can express various genes (wingless engrailed, hedgehog, cubitus interruptus, and patched) and where their protein products interact within a cell, and across neighboring cells.2025-01-022025-01-082023-04-06BIOMD0000001065MODEL2304060001BIOMD0000001065GO:0005886GO:0007367GO:0005634GO:00057371830FBgn0003892FBgn0000577FBgn0004859FBgn0284084FBgn0004644Q02936P09615P18502P02836P1953810.1038/35018085