{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006-biopax2.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006-biopax3.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006_url.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006_urn.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006.xpp","https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006.m","https://www.ebi.ac.uk/biomodels/model/download/MODEL0911270006?filename=MODEL0911270006.vcml"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Vijayalakshmi Chelliah"],"curationStatus":["Non-curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V4"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL0911270006"],"publication_pubmed":["4334846"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Guyton1972 HeartRateStrokeVolume"],"publication_year":["1972"],"submissionId":["MODEL0911270006"],"publication_authors":["A C Guyton, T G Coleman, H J Granger"],"first_author":["A C Guyton"],"publication":["4334846,\n                            null. null, 34.\n                            null"],"submitter_mail":["viji@ebi.ac.uk"],"submitter_affiliation":["EMBL-EBI"],"pubmed_title":["Circulation: overall regulation."],"pubmed_authors":["Guyton A C AC, Coleman T G TG, Granger H J HJ"],"additional_accession":[]},"is_claimable":false,"name":"Guyton1972_HeartRateStrokeVolume","description":"\n      \n        This a model from the article:      \n        Circulation: overall regulation.\n        \n          Guyton AC, Coleman TG, Granger HJ.      Annu Rev Physiol\n          1972;34:13-46      4334846\n          ,      \n        Abstract:\n        \n          This article is an experiment, one undertaken primarily because of the\nlong-term belief of Dr. Victor Hall, Editor of the Annual Review of Physiology fo\nr many years, that physiology is, or at least should be, an analytical subject,\nand that a method not utilized to its fullest advantage for organizing\nreview material is the systems analysis. Furthermore, one of the most likely\nareas in physiology for which a systems analysis could be of value would be\nin a discussion of circulatory regulation. Therefore, this article was undertaken\ndirectly at the request of the editors of the A ogy to attempt the welding togeth\ner of a systemsn annuaally Rsiesv ioewf coifr cPuhlaytsoiorlyregulation\nwith a review of the current literature in this field.\nThe systems analysis of circulatory regulation developed for this article\nis based on earlier, much less extensive analyses (Guyton and Coleman 1, 2); it i\ns illustrated in Figure 1. This analysis is comprised of 354 blocks, each of\nwhich represents one or more mathematical equations describing some\nphysiological facet of circulatory function. In general, each of the functional\nblocks has been the subject of research investigation by one or many investigator\ns,\nbut the analysis is based on cumulative knowledge of the circulation\nrather than simply on current literature. Therefore, the analysis presented\nhere is not a review of the current literature but is a framework to show how\nthe different regulations operate together in the overall system. Later in this\nreview we will attempt to show some of the voids still present in our knowledge\nof circulatory regulation (which is perhaps the most important value\nof performing systems analyses), and we will discuss the current research\nthat is attempting to fill these voids.\nA criticism that has often been made against systems analyses, and very\njustly so, is that they are usually designed to explain specific phenomena.\nTherefore, they too often are based on such bizarre concepts of function that\nthey not only fail to give correct predictions (other than the specific ones\nfor which they are designed) but, indeed, often give exactly reverse\npredictions. Therefore, the analysis of Figure 1 was based almost entirely on act\nual\nexperimental data, and it has been tested in computer simulations to see\nwhether or not it can predict the animal or human results of many different\ntypes of circulatory stresses induced either experimentally or as the result\nof clinical abnormalities. Figures 2 through 5 present simulations of some of\nthese experiments or clinical conditions. They will be described later in the\narticle.      \n      This model was taken from the      CellML repository\n          and automatically converted to SBML.      \n          The original model was:      \n        Guyton AC, Coleman TG, Granger HJ. (2008) - version01\n      \n  \n  This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.      \n          To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..      \n          To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n\n\n","dates":{"last_modification":"2009-11-27","publication":"2005-01-01","submission":"2009-11-27"},"accession":"MODEL0911270006","cross_references":{"pubmed":["4334846"],"biomodels__db":["MODEL0911270006"],"go":["GO:0002027"],"taxonomy":["9606"]}}