BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363.pdfhttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363-biopax2.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363-biopax3.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363_urn.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363.scihttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363.pnghttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363.xpphttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363.vcmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL0913003363?filename=MODEL0913003363.mprimaryOK200Vijayalakshmi ChelliahNon-curatedordinary differential equation modelL2V3https://www.ebi.ac.uk/biomodels/MODEL091300336316445978falseBioModelsSBMLModelsCui2006 CalciumHomeostasis2006MODEL0913003363Jiangjun Cui, Jaap A KaandorpJiangjun Cui16445978, In this study, based on currently available experimental observations on protein level, we constructed a mathematical model to describe calcium homeostasis in normally growing yeast cells (Saccharomyces cerevisiae). Simulation results show that tightly controlled low cytosolic calcium ion level can be a natural result under the general mechanism of gene expression feedback control. The calmodulin (a sensor protein) behavior in our model cell agrees well with relevant observations in real cells. Moreover, our model can qualitatively reproduce the experimentally observed response curve of real yeast cell responding to step-like disturbance in extracellular calcium ion concentration. Further investigations show that the feedback control mechanism in our model is as robust as it is in real cells.. 4, 39. Section Computational Science, Faculty of Science, University of Amsterdam, The Netherlands.viji@ebi.ac.ukEMBL-EBIIn this study, based on currently available experimental observations on protein level, we constructed a mathematical model to describe calcium homeostasis in normally growing yeast cells (Saccharomyces cerevisiae). Simulation results show that tightly controlled low cytosolic calcium ion level can be a natural result under the general mechanism of gene expression feedback control. The calmodulin (a sensor protein) behavior in our model cell agrees well with relevant observations in real cells. Moreover, our model can qualitatively reproduce the experimentally observed response curve of real yeast cell responding to step-like disturbance in extracellular calcium ion concentration. Further investigations show that the feedback control mechanism in our model is as robust as it is in real cells.Mathematical modeling of calcium homeostasis in yeast cells.Cui Jiangjun J, Kaandorp Jaap A JAfalseCui2006_CalciumHomeostasis This a model from the article: Mathematical modeling of calcium homeostasis in yeast cells. Cui J, Kaandorp JA. Cell Calcium 2006 Apr;39(4):337-48 16445978 , Abstract: In this study, based on currently available experimental observations on protein level, we constructed a mathematical model to describe calcium homeostasis in normally growing yeast cells (Saccharomyces cerevisiae). Simulation results show that tightly controlled low cytosolic calcium ion level can be a natural result under the general mechanism of gene expression feedback control. The calmodulin (a sensor protein) behavior in our model cell agrees well with relevant observations in real cells. Moreover, our model can qualitatively reproduce the experimentally observed response curve of real yeast cell responding to step-like disturbance in extracellular calcium ion concentration. Further investigations show that the feedback control mechanism in our model is as robust as it is in real cells. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Cui J, Kaandorp JA. (2006) - version03 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92. 2009-04-302005-01-012009-04-30MODEL091300336316445978MODEL0913003363GO:00550744932