{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131-biopax2.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131-biopax3.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131_urn.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131_url.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131.vcml","https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131.xpp","https://www.ebi.ac.uk/biomodels/model/download/MODEL0913145131?filename=MODEL0913145131.m"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Vijayalakshmi Chelliah"],"curationStatus":["Non-curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V3"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL0913145131"],"publication_pubmed":["17486452"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Corrias2007 GastricSMCellularActivation"],"publication_year":["2007"],"submissionId":["MODEL0913145131"],"publication_authors":["Alberto Corrias, Martin L Buist"],"first_author":["Alberto Corrias"],"publication":["17486452,\n                            A physiologically realistic quantitative description of the electrical behavior of a gastric smooth muscle (SM) cell is presented. The model describes the response of a SM cell when activated by an electrical stimulus coming from the network of interstitial cells of Cajal (ICC) and is mediated by the activation of different ion channels species in the plasma membrane. The conductances (predominantly Ca2+ and K+) that are believed to substantially contribute to the membrane potential fluctuations during slow wave activity have been included in the model. A phenomenological description of intracellular Ca2+ dynamics has also been included because of its primary importance in regulating a number of cellular processes. In terms of shape, duration, and amplitude, the resulting simulated smooth muscle depolarizations (SMDs) are in good agreement with experimentally recordings from mammalian gastric SM in control and altered conditions. This model has also been designed to be suitable for incorporation into large scale multicellular simulations.. 9, 35.\n                            Division of Bioengineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore."],"submitter_mail":["viji@ebi.ac.uk"],"submitter_affiliation":["EMBL-EBI"],"pubmed_abstract":["A physiologically realistic quantitative description of the electrical behavior of a gastric smooth muscle (SM) cell is presented. The model describes the response of a SM cell when activated by an electrical stimulus coming from the network of interstitial cells of Cajal (ICC) and is mediated by the activation of different ion channels species in the plasma membrane. The conductances (predominantly Ca2+ and K+) that are believed to substantially contribute to the membrane potential fluctuations during slow wave activity have been included in the model. A phenomenological description of intracellular Ca2+ dynamics has also been included because of its primary importance in regulating a number of cellular processes. In terms of shape, duration, and amplitude, the resulting simulated smooth muscle depolarizations (SMDs) are in good agreement with experimentally recordings from mammalian gastric SM in control and altered conditions. This model has also been designed to be suitable for incorporation into large scale multicellular simulations."],"pubmed_title":["A quantitative model of gastric smooth muscle cellular activation."],"pubmed_authors":["Corrias Alberto A, Buist Martin L ML"],"additional_accession":[]},"is_claimable":false,"name":"Corrias2007_GastricSMCellularActivation","description":"\n      \n        This a model from the article:      \n        A quantitative model of gastric smooth muscle cellular activation.\n        \n          Corrias A, Buist ML.      Ann Biomed Eng\n          2007 Sep;35(9):1595-607      17486452\n          ,      \n        Abstract:\n        \n          A physiologically realistic quantitative description of the electrical behavior\nof a gastric smooth muscle (SM) cell is presented. The model describes the\nresponse of a SM cell when activated by an electrical stimulus coming from the\nnetwork of interstitial cells of Cajal (ICC) and is mediated by the activation\nof different ion channels species in the plasma membrane. The conductances\n(predominantly Ca2+ and K+) that are believed to substantially contribute to the\nmembrane potential fluctuations during slow wave activity have been included in\nthe model. A phenomenological description of intracellular Ca2+ dynamics has\nalso been included because of its primary importance in regulating a number of\ncellular processes. In terms of shape, duration, and amplitude, the resulting\nsimulated smooth muscle depolarizations (SMDs) are in good agreement with\nexperimentally recordings from mammalian gastric SM in control and altered\nconditions. This model has also been designed to be suitable for incorporation\ninto large scale multicellular simulations.      \n      This model was taken from the      CellML repository\n          and automatically converted to SBML.      \n          The original model was:      \n        Corrias A, Buist ML. (2007) - version02\n      \n      \n          The original CellML model was created by:      \n      Corrias, Alberto,\n      \n          albertocorrias@nus.edu.sg      \n          National University of Singapore      \n          Division BioEngineering      \n    This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.      \n          To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n  In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..      \n  \n          To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n\n\n","dates":{"last_modification":"2009-04-28","publication":"2005-01-01","submission":"2009-04-28"},"accession":"MODEL0913145131","cross_references":{"pubmed":["17486452"],"biomodels__db":["MODEL0913145131"],"go":["GO:0014831"],"taxonomy":["9606"],"bto":["BTO:0001818"]}}