{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103-biopax2.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103_urn.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103_url.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103.vcml","https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103.xpp","https://www.ebi.ac.uk/biomodels/model/download/MODEL1006230103?filename=MODEL1006230103.m"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Camille Laibe"],"curationStatus":["Non-curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V4"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL1006230103"],"publication_pubmed":["11842064"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Heldt2002 OrthostaticStress heart"],"publication_year":["2002"],"submissionId":["MODEL1006230103"],"publication_authors":["Thomas Heldt, Eun B Shim, Roger D Kamm, Roger G Mark"],"first_author":["Thomas Heldt"],"publication":["11842064,\n                            The objective of this study is to develop a model of the cardiovascular system capable of simulating the short-term (< or = 5 min) transient and steady-state hemodynamic responses to head-up tilt and lower body negative pressure. The model consists of a closed-loop lumped-parameter representation of the circulation connected to set-point models of the arterial and cardiopulmonary baroreflexes. Model parameters are largely based on literature values. Model verification was performed by comparing the simulation output under baseline conditions and at different levels of orthostatic stress to sets of population-averaged hemodynamic data reported in the literature. On the basis of experimental evidence, we adjusted some model parameters to simulate experimental data. Orthostatic stress simulations are not statistically different from experimental data (two-sided test of significance with Bonferroni adjustment for multiple comparisons). Transient response characteristics of heart rate to tilt also compare well with reported data. A case study is presented on how the model is intended to be used in the future to investigate the effects of post-spaceflight orthostatic intolerance.. 3, 92.\n                            Harvard University-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA."],"submitter_mail":["laibe@ebi.ac.uk"],"submitter_affiliation":["EMBL-EBI"],"pubmed_abstract":["The objective of this study is to develop a model of the cardiovascular system capable of simulating the short-term (< or = 5 min) transient and steady-state hemodynamic responses to head-up tilt and lower body negative pressure. The model consists of a closed-loop lumped-parameter representation of the circulation connected to set-point models of the arterial and cardiopulmonary baroreflexes. Model parameters are largely based on literature values. Model verification was performed by comparing the simulation output under baseline conditions and at different levels of orthostatic stress to sets of population-averaged hemodynamic data reported in the literature. On the basis of experimental evidence, we adjusted some model parameters to simulate experimental data. Orthostatic stress simulations are not statistically different from experimental data (two-sided test of significance with Bonferroni adjustment for multiple comparisons). Transient response characteristics of heart rate to tilt also compare well with reported data. A case study is presented on how the model is intended to be used in the future to investigate the effects of post-spaceflight orthostatic intolerance."],"pubmed_title":["Computational modeling of cardiovascular response to orthostatic stress."],"pubmed_authors":["Heldt Thomas T, Shim Eun B EB, Kamm Roger D RD, Mark Roger G RG"],"name_synonyms":["cardiac structure., adult heart, branchial heart, cardium, Herz, Hearts"],"pubmed_abstract_synonyms":["Heart, IPP2A2, 0998/12, Heart Rate Control, Circulatory Systems, experimental, CV system, PNT-P1, ETS2, Ets2, DmelCG17077, Heartbeats, EY3-1, Pnt, Decompression, Migrant Workers, CG7826, PHAPII, 5730420M11Rik, pulse rate, School-Age, rate of heart contraction, DMPOINT1A, pntegfr, Rate, Cardiac, 0608/07, png, Chronotropy, responsivity, CG7835, Cardiac Chronotropy, CG42273, Intolerance, Min, D-ets-2, 3520, Pulse Rates, DmelCG42273, Pnt-P1, study, School-Age Populations, reactivity, SET, methods, Migrant Worker, pointed-RC, TAF-I, experimental 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J Appl Physiol\n          2002 Mar;92(3):1239-54      11842064\n          ,      \n        Abstract:\n        \n          The objective of this study is to develop a model of the cardiovascular system\ncapable of simulating the short-term (< or = 5 min) transient and steady-state\nhemodynamic responses to head-up tilt and lower body negative pressure. The\nmodel consists of a closed-loop lumped-parameter representation of the\ncirculation connected to set-point models of the arterial and cardiopulmonary\nbaroreflexes. Model parameters are largely based on literature values. Model\nverification was performed by comparing the simulation output under baseline\nconditions and at different levels of orthostatic stress to sets of\npopulation-averaged hemodynamic data reported in the literature. On the basis of\nexperimental evidence, we adjusted some model parameters to simulate\nexperimental data. Orthostatic stress simulations are not statistically\ndifferent from experimental data (two-sided test of significance with Bonferroni\nadjustment for multiple comparisons). Transient response characteristics of\nheart rate to tilt also compare well with reported data. A case study is\npresented on how the model is intended to be used in the future to investigate\nthe effects of post-spaceflight orthostatic intolerance.      \n      This model was taken from the      CellML repository\n          and automatically converted to SBML.      \n          The original model was:      \n        Heldt T, Shim EB, Kamm RD, Mark RG. (2002) - version=1.0\n      \n      \n          The original CellML model was created by:      \n      Catherine Lloyd\n      \n          c.lloyd@auckland.ac.nz      \n          The University of Auckland      \n    This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.      \n          To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n  In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..      \n  \n          To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n\n\n","dates":{"last_modification":"2010-06-25","publication":"2005-01-01","submission":"2010-06-23"},"accession":"MODEL1006230103","cross_references":{"pubmed":["11842064"],"biomodels__db":["MODEL1006230103"],"go":["GO:0002027"],"taxonomy":["9606"]}}