{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015-biopax2.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015-biopax3.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015_url.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015_urn.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015.m","https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015.xpp","https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL1108260015?filename=MODEL1108260015.vcml"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Michael Schubert"],"curationStatus":["Non-curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V4"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL1108260015"],"publication_pubmed":["15121060"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Qiao2004 ThrombinGeneration"],"publication_year":["2004"],"submissionId":["MODEL1108260015"],"publication_authors":["Y H Qiao, C Q Xu, Y J Zeng, X H Xu, H Zhao, H Xu"],"first_author":["Y H Qiao"],"publication":["15121060,\n                            The paper described a limited part of the coagulation pathway, and in particular the inhibitory effects of activated protein C in the context of thrombin production. This is a computational modeling study with various assumption made of kinetic rates laws and their summation. The level of complexity and assumed parameters makes conclusions uncertain. However, an interesting outcome is that kinetic reaction rates may show oscillation behavior under particular, high levels of protein C feedback inhibition. The model would defy quantitative practical use, but could have predictive value as a qualitative descriptor of coagulation.. 4, 26.\n                            Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing 100022, China."],"submitter_mail":["schubert@ebi.ac.uk"],"submitter_affiliation":["EBI"],"pubmed_abstract":["The paper described a limited part of the coagulation pathway, and in particular the inhibitory effects of activated protein C in the context of thrombin production. This is a computational modeling study with various assumption made of kinetic rates laws and their summation. The level of complexity and assumed parameters makes conclusions uncertain. However, an interesting outcome is that kinetic reaction rates may show oscillation behavior under particular, high levels of protein C feedback inhibition. The model would defy quantitative practical use, but could have predictive value as a qualitative descriptor of coagulation."],"pubmed_title":["The kinetic model and simulation of blood coagulation--the kinetic influence of activated protein C."],"pubmed_authors":["Qiao Y H YH, Xu C Q CQ, Zeng Y J YJ, Xu X H XH, Zhao H H, Xu H H"],"additional_accession":[]},"is_claimable":false,"name":"Qiao2004_ThrombinGeneration","description":"\n      \n        This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.      \n          To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n      In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..      \n      \n          To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n  \n\n","dates":{"last_modification":"2011-08-26","publication":"2005-01-01","submission":"2011-08-26"},"accession":"MODEL1108260015","cross_references":{"pubmed":["15121060"],"biomodels__db":["MODEL1108260015"],"go":["GO:0007596"],"taxonomy":["9606"],"bto":["BTO:0000089"]}}