{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000-biopax2.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000-biopax3.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000_url.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000_urn.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000.xpp","https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000.vcml","https://www.ebi.ac.uk/biomodels/model/download/MODEL1109160000?filename=MODEL1109160000.m"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Michael Schubert"],"curationStatus":["Non-curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V4"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL1109160000"],"publication_pubmed":["11248291"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Kogan2001 aPTT preincubation"],"publication_year":["2001"],"submissionId":["MODEL1109160000"],"publication_authors":["A E Kogan, D V Kardakov, M A Khanin"],"first_author":["A E Kogan"],"publication":["11248291,\n                            Activated partial thromboplastin time (APTT) is a laboratory test for the diagnosis of blood coagulation disorders. The test consists of two stages: The first one is the preincubation of a plasma sample with negatively charged materials (kaolin, ellagic acid etc.) to activate factors XII and XI; the second stage begins after the addition of calcium ions that triggers a chain of calcium-dependent enzymatic reactions resulting in fibrinogen clotting. Mathematical modeling was used for the analysis of the APTT test. The process of coagulation was described by a set of coupled differential equations that were solved by the numerical method. It was found that as little as 2.3 x 10(-9) microM of factor XIIa (1/10000 of its plasma concentration) is enough to cause the complete activation of factor XII and prekallikrein (PK) during the first 20 s of the preincubation phase. By the end of this phase, kallikrein (K) is completely inhibited, residual activity of factor XIIa is 54%, and factor XI is activated by 26%. Once a clot is formed, factor II is activated by 4%, factor X by 5%, factor IX by 90%, and factor XI by 39%. Calculated clotting time using protein concentrations found in the blood of healthy people was 40.5 s. The most pronounced prolongation of APTT is caused by a decrease in factor X concentration.. 4, 101.\n                            Biological Faculty, Department of Biochemistry, Room 129, Moscow State University, 119899, Moscow, Russia. al.kogan@mtu-net.ru"],"submitter_mail":["schubert@ebi.ac.uk"],"submitter_affiliation":["EBI"],"pubmed_abstract":["Activated partial thromboplastin time (APTT) is a laboratory test for the diagnosis of blood coagulation disorders. The test consists of two stages: The first one is the preincubation of a plasma sample with negatively charged materials (kaolin, ellagic acid etc.) to activate factors XII and XI; the second stage begins after the addition of calcium ions that triggers a chain of calcium-dependent enzymatic reactions resulting in fibrinogen clotting. Mathematical modeling was used for the analysis of the APTT test. The process of coagulation was described by a set of coupled differential equations that were solved by the numerical method. It was found that as little as 2.3 x 10(-9) microM of factor XIIa (1/10000 of its plasma concentration) is enough to cause the complete activation of factor XII and prekallikrein (PK) during the first 20 s of the preincubation phase. By the end of this phase, kallikrein (K) is completely inhibited, residual activity of factor XIIa is 54%, and factor XI is activated by 26%. Once a clot is formed, factor II is activated by 4%, factor X by 5%, factor IX by 90%, and factor XI by 39%. Calculated clotting time using protein concentrations found in the blood of healthy people was 40.5 s. The most pronounced prolongation of APTT is caused by a decrease in factor X concentration."],"pubmed_title":["Analysis of the activated partial thromboplastin time test using mathematical modeling."],"pubmed_authors":["Kogan A E AE, Kardakov D V DV, Khanin M A MA"],"additional_accession":[]},"is_claimable":false,"name":"Kogan2001_aPTT_preincubation","description":"\n      \n    \n      \n    This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.    \n        To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to    CC0 Public Domain Dedication\n        for more information.    \n      In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..    \n            \n        To cite BioModels Database, please use:    Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n            \n      \n    ","dates":{"last_modification":"2011-09-16","publication":"2005-01-01","submission":"2011-09-16"},"accession":"MODEL1109160000","cross_references":{"pubmed":["11248291"],"biomodels__db":["MODEL1109160000"]}}