{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000-biopax2.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000_url.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000_urn.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000.vcml","https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000.xpp","https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL1303140000?filename=MODEL1303140000.m"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"submitter":["Orianne Mazemondet"],"curationStatus":["Non-curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V4"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL1303140000"],"publication_pubmed":["22952611"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Mazemondet2012   beta catenin dynamics in human neural progenitor cells"],"publication_year":["2012"],"submissionId":["MODEL1303140000"],"publication_authors":["Orianne Mazemondet, Mathias John, Stefan Leye, Arndt Rolfs, Adelinde M Uhrmacher"],"first_author":["Orianne Mazemondet"],"publication":["22952611,\n                            Human neural progenitor cells (hNPCs) form a new prospect for replacement therapies in the context of neurodegenerative diseases. The Wnt/β-catenin signaling pathway is known to be involved in the differentiation process of hNPCs. RVM cells form a common cell model of hNPCs for in vitro investigation. Previous observations in RVM cells raise the question of whether observed kinetics of the Wnt/β-catenin pathway in later differentiation phases are subject to self-induced signaling. However, a concern when investigating RVM cells is that experimental results are possibly biased by the asynchrony of cells w.r.t. the cell cycle. In this paper, we present, based on experimental data, a computational modeling study on the Wnt/β-catenin signaling pathway in RVM cell populations asynchronously distributed w.r.t. to their cell cycle phases. Therefore, we derive a stochastic model of the pathway in single cells from the reference model in literature and extend it by means of cell populations and cell cycle asynchrony. Based on this, we show that the impact of the cell cycle asynchrony on wet-lab results that average over cell populations is negligible. We then further extend our model and the thus-obtained simulation results provide additional evidence that self-induced Wnt signaling occurs in RVM cells. We further report on significant stochastic effects that directly result from model parameters provided in literature and contradict experimental observations.. 8, 7.\n                            Modelling and Simulation Group, Institute of Computer Science, University of Rostock, Rostock, Germany."],"submitter_mail":["orianne.mazemondet@laposte.net"],"submitter_affiliation":["Humboldt Universität zu Berlin"],"pubmed_abstract":["Human neural progenitor cells (hNPCs) form a new prospect for replacement therapies in the context of neurodegenerative diseases. The Wnt/β-catenin signaling pathway is known to be involved in the differentiation process of hNPCs. RVM cells form a common cell model of hNPCs for in vitro investigation. Previous observations in RVM cells raise the question of whether observed kinetics of the Wnt/β-catenin pathway in later differentiation phases are subject to self-induced signaling. However, a concern when investigating RVM cells is that experimental results are possibly biased by the asynchrony of cells w.r.t. the cell cycle. In this paper, we present, based on experimental data, a computational modeling study on the Wnt/β-catenin signaling pathway in RVM cell populations asynchronously distributed w.r.t. to their cell cycle phases. Therefore, we derive a stochastic model of the pathway in single cells from the reference model in literature and extend it by means of cell populations and cell cycle asynchrony. Based on this, we show that the impact of the cell cycle asynchrony on wet-lab results that average over cell populations is negligible. We then further extend our model and the thus-obtained simulation results provide additional evidence that self-induced Wnt signaling occurs in RVM cells. We further report on significant stochastic effects that directly result from model parameters provided in literature and contradict experimental observations."],"pubmed_title":["Elucidating the sources of β-catenin dynamics in human neural progenitor cells."],"pubmed_authors":["Mazemondet Orianne O, John Mathias M, Leye Stefan S, Rolfs Arndt A, Uhrmacher Adelinde M AM"],"name_synonyms":["beta-catenin, Human, ctnnb1, CTNNB, OK/SW-cl.35, human being, Man (Taxonomy), Homo sapiens, Modern Man, Modern, Cell., Beta-catenin, Catnb, ctnnb, beta-Catenin, PRO2286, Man, Catenin, human, beta"],"pubmed_abstract_synonyms":["Forms, Dm DWnt3/5, Canonical, DWnt-5, NK-2, DWnt-4, Dint-1, DmelCG4889, dhc64C, nk-2, Neurologic Diseases, NK2, l(2)wg, Neurologic Degenerative Condition, Progress Reports, Neurodegenerative Diseases, dmTAF[[II]]230, wnt-4, int-1, Neurologic Disorders, Fs(3)Laborc, Summary Report, Dm-1, dhc64c, Dm-2, Dm-3, DmelCG1916, cDhc64C, WBSCR15, Dm Wg, Wnt-4, l(2)02657, Summary Reports, Wnt-1, Wnt-3, Dhc, DHC, Wnt-2, Nervous System Degenerative Diseases, signal transduction by protein phosphorylation, imprinted and ancient gene protein, Cell Division Cycles, average, Degenerative Condition, Man (Taxonomy), I, TFIID TAF250, Progress Report, cel, HDC16822, NTAL, EG:118B3.1, Neurodegenerative Disorder, DWnt5, WNT, Wnt, DWnt4, DWnt3, DWnt2, dhc, CD, Progress, Field Reports, Degenerative Neurologic Disease, Dwnt5, Dwnt4, Cell Cycles, Neurologic Degenerative Disease, Br, dWnt2, l(1)RC24, wnt, Sp, single organism signaling, l(1)EA142, dTAF[[II]]230, Pathway, anatomical protrusion, Papers, VND, Vnd, Modern, signal transduction by conformational transition, TAF200, Dhc46C, Fs(3)Sz18, TAFII-250, TAF250/230, results, signal transduction by trans-phosphorylation, Division Cycles, Literatures, signaling cascade, TAFII250, l(1)VE769, clone 2.4, Investigative Report, D-wnt-2, Dm vnd, l(1)EC6, Signaling Pathway, DWint-1, DHC64C, CG4889, DWnt3/5, fg, anon-WO03040301.228, Division Cycle, Degenerative Diseases, Wnt beta-Catenin Signaling Pathway, anon-EST:Liang-2.4, WG, Field, cDhc, Dhc64, common, Neurologic Disease, CG17603, TAF[[II]], human, CG1916, Report, signaling pathway, Su(Gl)77, Taf250, Degenerative, spine, SR3-5, Dm-NK2, Wnt Signalings, Wg, HMW MAP, E430016J11Rik, TAF230, Wnt Signaling, d230, Canonical Wnt Pathway, human being, Degenerative Neurologic Disorders, l(3)64Ca, dTAFII250, Canonical Wnt, EfW1, Ximpact, cerebral degeneration disease, DWnt-3/5, l(1)GA100, Human, protrusion, Cdhc, dNK-2, Investigative, Homo sapiens, dmTAF1, Taf230, DmelCG7507, Cycle, Dhc64c, Man, TAF250, Cycles, study, Wnt beta Catenin Signaling Pathway, Nervous System, Taf200, dTAF[[II]]250, DmelCG6407, cell, Cell Division Cycle, cell-division cycle, Taf1p, Cell Division, dWnt, EC6, Wnt/Wg, Neurodegenerative Disorders, Wnt1, HSPC046, Wnt3, l(1)GA122, wnt4, wnt3, wnt2, dTAF250, Neurologic, wnt1, signalling pathway, Wnt3/5, Neurologic Degenerative Diseases, DmelCG4698, Lab, LAB, CG6172, Degenerative Neurologic Diseases, wnt5, Signaling, signal transduction by cis-phosphorylation, Nkx2, Spinal Cord, Canonical Wnt Pathways, TAF, Investigative Reports, Fs(3)Lab, WBSCR5, TAF[[II]]250, Neurologic Disorder, l(2)rO727, lab, l(3)84Ab, BG:DS00004.13, Cell, wgl, impact-a, CG7507, dTAF230, Literatures., Degenerative Neurologic Disorder, spd, l(1)1Bf, l(1)VA208, p230, Research Reports, TAF[[II]]250/230, TFIID, imprinted and ancient gene protein homolog, IMPACT, vnd/NK-2, Dynein, signalling cascade, DmelCG6172, Wnt Pathway, Taf[[II]]250, Degenerative Conditions, TAF[[II]]230, CG4698, Dwnt-2, Dwnt-3, Wnt Signaling Pathways, Neurologic Degenerative Conditions, TAF[II]250, Dm DWnt2, Dm DWnt4, FCP-A, WBS15, DmelCG17603, signalling process, Reports, Dwnt-5, Modern Man, Neurodegenerative Disease, Central Nervous System, DWnt-3, DWnt-2, Summary, DWnt-1, RWDD5, Gla, Field Report, CG6407, TAF1"],"description_synonyms":["Desc, DESCR., Description, Descriptive, Descriptor, description, Product Description/Appearance"],"pubmed_title_synonyms":["Human, Cell., human being, Man (Taxonomy), Homo sapiens, Man, Modern Man, human, Modern"],"additional_accession":[]},"is_claimable":false,"name":"Mazemondet2012 - beta-catenin dynamics in human neural progenitor cells","description":"No description","dates":{"last_modification":"2013-03-15","publication":"2005-01-01","submission":"2013-03-14"},"accession":"MODEL1303140000","cross_references":{"pubmed":["22952611"],"biomodels__db":["MODEL1303140000"],"taxonomy":["9606"],"bto":["BTO:0000138"]}}