BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000.pdfhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000-biopax2.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000-biopax3.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000_urn.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000.mhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000.scihttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000.pnghttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000.xpphttps://www.ebi.ac.uk/biomodels/model/download/MODEL1401290000?filename=MODEL1401290000.vcmlprimaryOK200Alex ThomasNon-curatedL2V1https://www.ebi.ac.uk/biomodels/MODEL140129000024473230falseBioModelsSBMLModelsThomas2014 The effect of aspirin resistance on platelet metabolism (constraint based modelling)2014MODEL1401290000Non KineticAlex Thomas, Sorena Rahmanian, Aarash Bordbar, Bernhard Ø Palsson, Neema JamshidiAlex Thomas24473230, Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed using 33 proteomic datasets and 354 literature references. The network contains enzymes mapping to 403 diseases and 231 FDA approved drugs, alluding to an expansive scope of biochemical transformations that may affect or be affected by disease processes in multiple organ systems. The effect of aspirin (ASA) resistance on platelet metabolism was evaluated using constraint-based modeling, which revealed a redirection of glycolytic, fatty acid, and nucleotide metabolism reaction fluxes in order to accommodate eicosanoid synthesis and reactive oxygen species stress. These results were confirmed with independent proteomic data. The construction and availability of iAT-PLT-636 should stimulate further data-driven, systems analysis of platelet metabolism towards the understanding of pathophysiological conditions including, but not strictly limited to, coagulopathies.. null, 4. 1] Department of Bioinformatics and Systems Biology, 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093-0412 [2] University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093-0412.a1xt06@gmail.comUniversity of California, San DiegoRecently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed using 33 proteomic datasets and 354 literature references. The network contains enzymes mapping to 403 diseases and 231 FDA approved drugs, alluding to an expansive scope of biochemical transformations that may affect or be affected by disease processes in multiple organ systems. The effect of aspirin (ASA) resistance on platelet metabolism was evaluated using constraint-based modeling, which revealed a redirection of glycolytic, fatty acid, and nucleotide metabolism reaction fluxes in order to accommodate eicosanoid synthesis and reactive oxygen species stress. These results were confirmed with independent proteomic data. The construction and availability of iAT-PLT-636 should stimulate further data-driven, systems analysis of platelet metabolism towards the understanding of pathophysiological conditions including, but not strictly limited to, coagulopathies.Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance.Thomas Alex A, Rahmanian Sorena S, Bordbar Aarash A, Palsson Bernhard Ø BØ, Jamshidi Neema NO-acetylsalicylic acid, Benzoic acid, biochemical pathways, 2-(Acetyloxy)benzoic Acid, acido acetilsalicilico, Metabolic Process, acidum acetylsalicylicum, degradation, Process, Processes, Blood, metabolism resulting in cell growth, Blood Platelet, Metabolic Concepts, Endosprin, Acetylsalicylsaeure, Metabolic Processes, Anabolism., Micristin, Polopiryna, Acetysal, Concept, Metabolic Phenomena, Solprin, Metabolism Concepts, Thrombocytes, Metabolism, resistance, Phenomena, thrombocyte, Acetylsalicylate, Zorprin, Concepts, 2-(ACETYLOXY)BENZOIC ACID, Solupsan, secretion, Polopirin, Metabolism Concept, Aloxiprimum, Phenomenon, Metabolism Phenomena, metabolism, Magnecyl, Metabolic Phenomenon, o-carboxyphenyl acetate, Acid, Easprin, Ecotrin, multicellular organism metabolic process, biodegradation, Metabolic, catabolism, acide 2-(acetyloxy)benzoique, Acylpyrin, Dispril, ASA, Metabolic Concept, acide acetylsalicylique, metabolic process resulting in cell growth, enucleate thrombocyte, salicylic acid acetate, o-acetoxybenzoic acid, 2-(acetyloxy)-, Aspirin, Acetylsalicylic, anucleate thrombocyte, 2-Acetoxybenzenecarboxylic acid, 2-acetoxybenzoic acid, blood platelet, Platelet, biotransformation, Acetylsalicylic Acid, platelet, Thrombocyte, Azetylsalizylsaeure, Catabolism, Colfarit, PlateletsDesc, DESCR., Description, Descriptive, Descriptor, description, Product Description/Appearancebiochemical pathways, O-acetylsalicylic acid, Benzoic acid, 2-(Acetyloxy)benzoic Acid, acido acetilsalicilico, Metabolic Process, degradation, Process, acidum acetylsalicylicum, Processes, Blood, metabolism resulting in cell growth, Blood Platelet, Metabolic Concepts, Endosprin, Metabolic Processes, Acetylsalicylsaeure, Micristin, Polopiryna, Acetysal, Concept, Metabolic Phenomena, Solprin, Metabolism Concepts, Thrombocytes, Metabolism, Phenomena, thrombocyte, Concepts, Acetylsalicylate, Zorprin, 2-(ACETYLOXY)BENZOIC ACID, secretion, Solupsan, Metabolism Concept, Polopirin, Aloxiprimum, Phenomenon, Metabolism Phenomena, metabolism, Magnecyl, Metabolic Phenomenon, o-carboxyphenyl acetate, Acid, Easprin, multicellular organism metabolic process, Ecotrin, resistance., biodegradation, Metabolic, catabolism, acide 2-(acetyloxy)benzoique, Acylpyrin, Dispril, ASA, Metabolic Concept, acide acetylsalicylique, metabolic process resulting in cell growth, enucleate thrombocyte, salicylic acid acetate, o-acetoxybenzoic acid, 2-(acetyloxy)-, Aspirin, Acetylsalicylic, anucleate thrombocyte, 2-Acetoxybenzenecarboxylic acid, 2-acetoxybenzoic acid, blood 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enzyme activity, Eicosanoid, medical condition, Medications, Micristin, System Dynamics Analyses, Concept, Metabolic Phenomena, Metabolism Concepts, Fettsaeure, System Dynamics, Dynamics Analysis, Icosanoid, Systems, Phenomena, condition, Active, Systems Thinking, Approach, Complexity Analysis, metabolism, Magnecyl, Metabolic Phenomenon, multicellular organism metabolic process, biodegradation, Metabolic, Pharmaceutic Preparations, acide gras, enucleate thrombocyte, PLT, Systems Medicine, Drug, Preparations, Systems Approach, Agent-Based Modeling, Acetylsalicylic, Modern Man, Pro-Oxidants, Pharmaceutical Products, Pharmaceutical Preparation, AnabolismfalseThomas2014 - The effect of aspirin resistance on platelet metabolism (constraint-based modelling)No description2014-01-312005-01-012014-01-29MODEL140129000024473230MODEL1401290000GO:0046456