BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000.pdfhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000-biopax2.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000-biopax3.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000_urn.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000.scihttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000.pnghttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000.xpphttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000.vcmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1409170000?filename=MODEL1409170000.mprimary200OKAlexander MazeinNon-curatedL2V4https://www.ebi.ac.uk/biomodels/MODEL140917000023583456falseBioModelsSBMLModelsMazein2013 Cholesterol biosynthesis pathway2013MODEL1409170000Non KineticAlexander Mazein, Steven Watterson, Wei-Yuan Hsieh, William J Griffiths, Peter GhazalAlexander Mazein23583456, Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.. 1, 86. Division of Pathway Medicine, University of Edinburgh, Chancellor's Building, Little France Crescent, Edinburgh EH16 4SB, Scotland, UK. a.mazein@oist.jpa.mazein@gmail.comUniversity of EdinburghCholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.Mazein Alexander A, Watterson Steven S, Hsieh Wei-Yuan WY, Griffiths William J WJ, Ghazal Peter PfalseMazein2013 - Cholesterol biosynthesis pathwayNo description2015-01-082015-04-152014-09-17MODEL140917000023583456MODEL1409170000