BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1503050000?filename=MODEL1503050000.pdfhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1503050000?filename=MODEL1503050000_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1503050000?filename=MODEL1503050000_urn.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1503050000?filename=MODEL1503050000.vcmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1503050000?filename=MODEL1503050000.scihttps://www.ebi.ac.uk/biomodels/model/download/MODEL1503050000?filename=MODEL1503050000.pngprimaryOK200Kieran SmallboneNon-curatedordinary differential equation modelL2V4https://www.ebi.ac.uk/biomodels/MODEL1503050000falseBioModelsBIOMD0000000051 biomodels.db MODEL1501300000 biomodels.dbSBMLModelsSmallbone2015 Multi scale model of E. coli metabolismMODEL1503050000Smallbone K.1, Millard P.2Smallbone K.110.7287/peerj.preprints.914v1, In response to environmental and genetic perturbations, micro-organisms may regulate their metabolism both metabolically – via metabolite-enzyme interactions – and hierarchically – via modulating enzyme capacities. In this report, we develop a combined metabolic and genetic regulatory model of E. coli that may be used to test this multi-scale response.. null, null. 1 Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, United Kingdom 2 INSA, UPS, INP, LISBP, INRA, UMR792 Ingenierie des Systemes Biologiques et des Procedes, CNRS, UMR550, Université de Toulouse, Toulouse, Francekieran.smallbone@ncl.ac.uk10.7287/peerj.preprints.914v1Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK.falseSmallbone2015 - Multi-scale model of E. coli metabolismNo description2016-02-102016-02-102015-03-05MODEL1503050000R00658R01518R00756R00771R01512R00200R01015R00959R00835R02035R01827R01641R01067R01070R01061R00345R00209R01528R01056R01529R009484.2.1.114.1.2.135.4.2.12.7.1.115.3.1.92.7.2.35.4.2.22.7.1.405.3.1.13.1.1.311.1.1.492.2.1.22.2.1.11.2.1.124.1.1.311.2.1.511.1.1.445.3.1.65.1.3.12.7.7.27rn00620REACT_1255REACT_605REACT_736REACT_1272REACT_162REACT_1811REACT_1602REACT_1847REACT_469REACT_1186REACT_576REACT_1400REACT_1524REACT_611REACT_6907REACT_1522CHEBI:16108CHEBI:17665CHEBI:18021CHEBI:15361CHEBI:16077CHEBI:4167CHEBI:17234CHEBI:15946CHEBI:16863CHEBI:16905CHEBI:15721CHEBI:17138CHEBI:48153CHEBI:16332CHEBI:17797CHEBI:16001CHEBI:17794CHEBI:17835CHEBI:17363MODEL1503050000GO:0004347GO:0005576GO:0005829C00279C00111C05345C00668C00074C00022C00031C00085C00103C00345C00354C00281C00661C00231C00117C00236C00197C00631C0019910.7287/peerj.preprints.914v1