BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025.pdfhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025-biopax2.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025-biopax3.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025_urn.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025.mhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025.vcmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025.xpphttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025.scihttps://www.ebi.ac.uk/biomodels/model/download/MODEL1507180025?filename=MODEL1507180025.pngprimaryOK200Nicolas Le NovèreNon-curatedconstraint-based modelL3V1https://www.ebi.ac.uk/biomodels/MODEL150718002515378067falseBioModelsSBMLModelsHong2004 Genome scale metabolic network of Mannheimia succiniciproducens (iSH335)2004MODEL1507180025Non KineticHong SH, Kim JS, Lee SY, In YH, Choi SS, Rih JK, Kim CH, Jeong H, Hur CG, Kim JJHong SH15378067,
The rumen represents the first section of a ruminant animal's stomach, where feed is collected and mixed with microorganisms for initial digestion. The major gas produced in the rumen is CO(2) (65.5 mol%), yet the metabolic characteristics of capnophilic (CO(2)-loving) microorganisms are not well understood. Here we report the 2,314,078 base pair genome sequence of Mannheimia succiniciproducens MBEL55E, a recently isolated capnophilic Gram-negative bacterium from bovine rumen, and analyze its genome contents and metabolic characteristics. The metabolism of M. succiniciproducens was found to be well adapted to the oxygen-free rumen by using fumarate as a major electron acceptor. Genome-scale metabolic flux analysis indicated that CO(2) is important for the carboxylation of phosphoenolpyruvate to oxaloacetate, which is converted to succinic acid by the reductive tricarboxylic acid cycle and menaquinone systems. This characteristic metabolism allows highly efficient production of succinic acid, an important four-carbon industrial chemical.. null, 22.
Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Rese Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, Republic of Korea.n.lenovere@gmail.comThe Babraham InstituteThe rumen represents the first section of a ruminant animal's stomach, where feed is collected and mixed with microorganisms for initial digestion. The major gas produced in the rumen is CO(2) (65.5 mol%), yet the metabolic characteristics of capnophilic (CO(2)-loving) microorganisms are not well understood. Here we report the 2,314,078 base pair genome sequence of Mannheimia succiniciproducens MBEL55E, a recently isolated capnophilic Gram-negative bacterium from bovine rumen, and analyze its genome contents and metabolic characteristics. The metabolism of M. succiniciproducens was found to be well adapted to the oxygen-free rumen by using fumarate as a major electron acceptor. Genome-scale metabolic flux analysis indicated that CO(2) is important for the carboxylation of phosphoenolpyruvate to oxaloacetate, which is converted to succinic acid by the reductive tricarboxylic acid cycle and menaquinone systems. This characteristic metabolism allows highly efficient production of succinic acid, an important four-carbon industrial chemical.The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens.Hong Soon Ho SH, Kim Jin Sik JS, Lee Sang Yup SY, In Yong Ho YH, Choi Sun Shim SS, Rih Jeong-Keun JK, Kim Chang Hoon CH, Jeong Haeyoung H, Hur Cheol Goo CG, Kim Jae Jong JJMannheimia succiniciproducens., scale (sensu Metazoa), scale tissue, scales, scale, Genomes, plant peltate hair, peltate hairbiochemical pathways, Ammonium, dairy cow, scale tissue, Metabolic Process, 2-Propenoic acid, multi-cellular organism, Esters, mol, Processes, Carbon 12., Feature, Metabolic Flux, Menaquinone, peltate hair, Metabolic Concepts, 2-trans, nip, E-948, carbon, 8O, reductive citric acid pathway, Metabolic Processes, DmelCG4482, ventriculus, FUMARATE, Flux Analysis, Tier, Succinate, dioxygene, stomach chamber, cattle, Carbon-12, Metabolism, oxigeno, B1, l(2)SH1330, Concepts, 1, Fumaric Acid Ester, Menaquinones, germacrene A synthase activity, Analysis, Metabolism Concept, E948, animal, Phenomenon, Metabolism Phenomena, l(2)br23, Ammonium Succinate, Metabolic Flux Analyses, C, Genomes, Analyses, 2 Ethanedicarboxylic Acid, Butanedioic Acid, catabolism, plant peltate hair, O, Oxygen-16, 4-Butanedioic Acid, Bos bovis, Metabolic Concept, Fumaric Acid Esters, 35Bb, metazoa, metabolic process resulting in cell growth, reductive Kreb's cycle, free, PA1, Oxygen, Bos Tauurus, anterior intestine, Kohlenstoff, oxen, g, [OO], reductive carboxylic acid cycle, Base Pair, Acid Esters, Carbon, C16orf53, biotransformation, scale (sensu Metazoa), domestic cow, Fumarate, Characteristics, Catabolism, reductive carboxylate cycle, Potassium, molecular oxygen, fumarate, Base Pairings, (+)-germacrene A synthase activity, paunch, Oxygen 16, cow, degradation, Process, CG4482, body, animalia, 6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity, metabolism resulting in cell growth, l(2)35Bb, Ester, Acid Ester, ion(1-), whole body, 2-(phosphonooxy)-, Potassium Succinate, GAST, Vitamin K Quinone, (+)-(10R)-germacrene A synthase activity, carbone, oxygen, Concept, Metabolic Phenomena, Fumaric, carbono, Vitreous, Metabolism Concepts, organism, Stomachs, l(2)br3, l35Bb, Characteristic, Flux Analyses, reductive TCA cycle, Vitamin K2, Sauerstoff, Bos primigenius taurus, Phenomena, feed, sequence, secretion, domestic cattle, oxygene, scales, GAS, carboxylation, 6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity, metabolism, OXYGEN MOLECULE, Metabolic Phenomenon, Base Pairs, O2, multicellular organism metabolic process, Disauerstoff, dioxygen, (2E)-but-2-enedioate, 4 Butanedioic Acid, whole organism, biodegradation, scale, Metabolic, 6C, Rumens, ion(2-), Fumarate Esters, gas, CG15268, (E)-2-butenedioic acid, Features, primary structure of sequence macromolecule, l(2)SH2 1330, br3, Vitreous Carbon, single-organism metabolic process, Fumaric Acid, ox, Koerper, carbonium, Mannheimia succiniciproducens, mesenteron, NIP, BG:DS01219.1, gaster, bovine, E 948, 2-Ethanedicarboxylic Acid, Dioxygen, Anabolismbiochemical pathways, extent, InChIKey=CURLTUGMZLYLDI-UHFFFAOYAO, dairy cow, scale tissue, Metabolic Process, 11alpha, Public Sectors, Esters, determination, PLXN2, TalANAc, fond, Metabolic Concepts, nip, Elav-like generic protein, CycEI, Tier, Succinate, Ccne, stomach chamber, Carbon-12, oxigeno, B1, l(2)SH1330, Concepts, 1, Fumaric Acid Ester, Menaquinones, germacrene A synthase activity, Metabolism Concept, Public Enterprise, E948, animal, Phenomenon, Ammonium Succinate, C, Genomes, 2 Ethanedicarboxylic Acid, catabolism, plant peltate hair, O, Oxygen-16, 4-Butanedioic Acid, Public Domains, Bos bovis, 35Bb, metabolic process resulting in cell growth, free, Elavl1, PA1, Oxygen, 13E, Bos Tauurus, anterior intestine, oxen, g, [OO], Carbon, C16orf53, biotransformation, domestic cow, Fumarate, Catabolism, mKIAA0463, fumarate, Base Pairings, (+)-germacrene A synthase activity, paunch, PlexA2, Process, completeness, animalia, metabolism resulting in cell growth, Ester, Acid Ester, Potassium Succinate, 2-(acetylamino)-2-deoxy-, GAST, Cyc E, br37, Fsrg1, Vitreous, organism, RING3, AW457381, Stomachs, l(2)br3, l35Bb, BG:DS07108.3, Sauerstoff, Public Domain, FSRG1, Domains, secretion, ELAV (Embryonic lethal, GAS, carboxylation, l(2)05206, 6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity, Domain, HuR, Disauerstoff, dioxygen, 4 Butanedioic Acid, whole organism, 6C, Rumens, p36, O=C=O, Hua, Fumarate Esters, 15S)-, gas, elrA, (E)-2-butenedioic acid, l(2)SH2 1330, HUR, Vitreous Carbon, Fumaric Acid, Sector, l35Dd, (5Z, Koerper, carbonium, hua, BG:DS01219.1, bovine, Plxn2, Fsrg-1, Dioxygen, NAT, Nat, OCT, Ammonium, hur, 2-Propenoic acid, Sectors, D17H6S113E, alpha-L-Talopyranuronic acid, multi-cellular organism, cycline, mol, Processes, Menaquinone, DmcyclinE, peltate hair, number, 2-trans, E-948, alpha-L-N-acetyltalosaminuronic acid, cycE, carbon, Copyrights, 8O, elavl1, Metabolic Processes, FSH, DmelCG4482, presence, ventriculus, l(2)br37, 2410055N02Rik, Protein Elavl1, CYCLE, melg, FUMARATE, cdi7, cyclinE, InChI=1/CO2/c2-1-3, dioxygene, cattle, Metabolism, Cdi7, CDI7, MelG, ElrA, Metabolism Phenomena, Enterprises, l(2)br23, CYCE, abnormal vision, dioxidocarbon, Butanedioic Acid, DmelCG3938, CyclE, 3938, elav1, Metabolic Concept, Fumaric Acid Esters, 2810428A13Rik, metazoa, Ring3, DmcycE, Public Enterprises, l(2)k05007, dm-cycE, Kohlenstoff, Abstract, Base Pair, Acid Esters, scale (sensu Metazoa), Enterprise, ELAV1, Potassium, molecular oxygen, Oxygen 16, cow, degradation, CG4482, body, 6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity, l(2)35Bb, [CO2], carbonic anhydride, ion(1-), whole body, 2-(phosphonooxy)-, Vitamin K Quinone, (+)-(10R)-germacrene A synthase activity, carbone, AA589422, oxygen, isoform CRA_a, Concept, Metabolic Phenomena, Fumaric, carbono, Metabolism Concepts, count in organism, CO(2), l(2)k02514, DmCycE, Vitamin K2, Bos primigenius taurus, Public, AW228947, chemical analysis, Hu-antigen R, Phenomena, sequence, feed, Drosophila)-like 1 (Hu antigen R) (Predicted), domestic cattle, mKIAA4005, CyeE, scales, oxygene, metabolism, OXYGEN MOLECULE, Data Base, Metabolic Phenomenon, Base Pairs, O2, multicellular organism metabolic process, (2E)-but-2-enedioate, D6S113E, l(2)k02602, scale, biodegradation, Metabolic, Rnf3, RNF3, Frg-1, l(2)35Dd, ion(2-), CG15268, primary structure of sequence macromolecule, W91709, Carbon 12, br3, D-CycE, Xel-1, single-organism metabolic process, ox, Mannheimia succiniciproducens, mesenteron, NIP, Public., assay, quantitative, gaster, E 948, 2-Ethanedicarboxylic Acid, CG3938, alpha-L-2-N-acetylamino-2-desoxytaluronic acid, Anabolism, presence or absence in organismMannheimia succiniciproducens., sequence, Rumens, paunch, Genomes, primary structure of sequence macromoleculefalseHong2004 - Genome-scale metabolic network of Mannheimia succiniciproducens (iSH335)
Hong2004 - Genome-scale metabolic network of
Mannheimia succiniciproducens (iSH335)
This model is described in the article:
The genome sequence of the
capnophilic rumen bacterium Mannheimia succiniciproducens.
Hong SH, Kim JS, Lee SY, In YH, Choi
SS, Rih JK, Kim CH, Jeong H, Hur CG, Kim JJ.
Nat. Biotechnol. 2004 Oct; 22(10):
1275-1281
Abstract:
The rumen represents the first section of a ruminant
animal's stomach, where feed is collected and mixed with
microorganisms for initial digestion. The major gas produced in
the rumen is CO(2) (65.5 mol%), yet the metabolic
characteristics of capnophilic (CO(2)-loving) microorganisms
are not well understood. Here we report the 2,314,078 base pair
genome sequence of Mannheimia succiniciproducens MBEL55E, a
recently isolated capnophilic Gram-negative bacterium from
bovine rumen, and analyze its genome contents and metabolic
characteristics. The metabolism of M. succiniciproducens was
found to be well adapted to the oxygen-free rumen by using
fumarate as a major electron acceptor. Genome-scale metabolic
flux analysis indicated that CO(2) is important for the
carboxylation of phosphoenolpyruvate to oxaloacetate, which is
converted to succinic acid by the reductive tricarboxylic acid
cycle and menaquinone systems. This characteristic metabolism
allows highly efficient production of succinic acid, an
important four-carbon industrial chemical.
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2015-07-282015-07-302015-07-18MODEL150718002515378067MODEL1507180025