{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005-biopax2.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005-biopax3.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005_url.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005_urn.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005.m","https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL1511100005?filename=MODEL1511100005.xpp"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Petri-Jaan Lahtvee"],"curationStatus":["Non-curated"],"levelVersion":["L2V3"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL1511100005"],"publication_pubmed":["27307591"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Lahtvee2016   Automatically generated model for S. cerevisiae   etoh40 3"],"publication_year":["2016"],"submissionId":["MODEL1511100005"],"modelFlag":["Non Kinetic"],"publication_authors":["Petri-Jaan Lahtvee, Rahul Kumar, Björn M Hallström, Jens Nielsen"],"first_author":["Petri-Jaan Lahtvee"],"publication":["27307591,\n                            Yeast cell factories encounter physical and chemical stresses when used for industrial production of fuels and chemicals. These stresses reduce productivity and increase bioprocess costs. Understanding the mechanisms of the stress response is essential for improving cellular robustness in platform strains. We investigated the three most commonly encountered industrial stresses for yeast (ethanol, salt, and temperature) to identify the mechanisms of general and stress-specific responses under chemostat conditions in which specific growth rate-dependent changes are eliminated. By applying systems-level analysis, we found that most stress responses converge on mitochondrial processes. Our analysis revealed that stress-specific factors differ between applied stresses; however, they are underpinned by an increased ATP demand. We found that when ATP demand increases to high levels, respiration cannot provide sufficient ATP, leading to onset of respirofermentative metabolism. Although stress-specific factors increase ATP demand for cellular growth under stressful conditions, increased ATP demand for cellular maintenance underpins a general stress response and is responsible for the onset of overflow metabolism.. 15, 27.\n                            Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, 412 96 Gothenburg, Sweden."],"submitter_mail":["lahtvee@chalmers.se"],"submitter_affiliation":["Chalmers"],"pubmed_abstract":["Yeast cell factories encounter physical and chemical stresses when used for industrial production of fuels and chemicals. These stresses reduce productivity and increase bioprocess costs. Understanding the mechanisms of the stress response is essential for improving cellular robustness in platform strains. We investigated the three most commonly encountered industrial stresses for yeast (ethanol, salt, and temperature) to identify the mechanisms of general and stress-specific responses under chemostat conditions in which specific growth rate-dependent changes are eliminated. By applying systems-level analysis, we found that most stress responses converge on mitochondrial processes. Our analysis revealed that stress-specific factors differ between applied stresses; however, they are underpinned by an increased ATP demand. We found that when ATP demand increases to high levels, respiration cannot provide sufficient ATP, leading to onset of respirofermentative metabolism. Although stress-specific factors increase ATP demand for cellular growth under stressful conditions, increased ATP demand for cellular maintenance underpins a general stress response and is responsible for the onset of overflow metabolism."],"pubmed_title":["Adaptation to different types of stress converge on mitochondrial metabolism."],"pubmed_authors":["Lahtvee Petri-Jaan PJ, Kumar Rahul R, Hallström Björn M BM, Nielsen Jens J"],"description_synonyms":["Desc, DESCR., Description, Descriptive, Descriptor, description, Product Description/Appearance"],"name_synonyms":["Saccharomyces oviformis, Yeast, lager beer yeast., Saccharomyces cerevisiae 'var. diastaticus', Brewer's, baker's yeast, Saccharomyes cerevisiae, Baker, Saccharomyces uvarum var. melibiosus, Saccharomyces italicus, Saccaromyces cerevisiae, S. cerevisiae, Baker's Yeasts, Sccharomyces cerevisiae, Saccharomyces cerevisiae (Desm.) Meyen ex E.C. Hansen, S cerevisiae, Candida robusta, Saccharomyces diastaticus, Saccharomyces capensis, yeast, Baker's, Mycoderma cerevisiae, 1883, Baker's Yeast, brewer's yeast, Brewer's Yeast, Baker Yeast"],"pubmed_abstract_synonyms":["biochemical pathways, Striadyne, Metabolic Process, Grain Alcohol, determination, Adenosine Triphosphate, Metabolic Concepts, Anabolism., 1-hydroxyethane, Productivity, alcohol, dmTAF[[II]]230, Readability, Ethanol, halite, responsivity, Alkohol, ionic compounds, Concepts, Msal-1, Metabolism Concept, Phenomenon, increased, Chromium Adenosine Triphosphate, Grain, TFIID TAF250, cel, catabolism, non-developmental growth of a unicellular organism, Ethyl, Salt, Saccharomyes cerevisiae, Age of onset, Msal, metabolic process resulting in cell growth, Aethanol, Saccharomyces uvarum var. melibiosus, [CH2Me(OH)], sel, Salz, salts, cloruro sodico, salt, Dehydrated ethanol, ATPsyn b, Saccharomyces capensis, CrATP, Cr(H2O)4 ATP, cellular growth, biotransformation, Strains, brewer's yeast, Catabolism, ATP, Chromium Ammonium Salt, spiritus vini, ATPsyn-&bgr, dTAF[[II]]230, rock salt, anatomical protrusion, ATPsyn-b, Alcohol, Process, metabolism resulting in cell growth, TAF200, Ethyl alcohol, TAFII-250, TAF250/230, Absolute Alcohol, TAFII250, common salt, ATP synthase D chain, non-developmental cell growth, Manganese Salt, Magnesium Salt, secretion, ETHANOL, [OEtH], CG11154, Yeast, Mitochondrial, EtOH, Spalt, ionic compound, CG17603, natrii chloridum, TAF[[II]], alcohol etilico, Methylcarbinol, CaATP, breathing, Taf250, spine, SR3-5, MgATP, Strains and Sprains, TAF230, accessory, d230, Magnesium Adenosine Triphosphate, respiration, Processes, etanol, ATP-MgCl2, baker's yeast, dTAFII250, IB, Metabolic Processes, EfW1, mitochondrial, supernumerary, Saccharomyces italicus, Adenylpyrophosphate, protrusion, Aethylalkohol, dmTAF1, Taf230, Metabolism, ATP-synbeta, yeast, Sprains, Metabolism Phenomena, lager beer yeast, TAF250, reactivity, Taf200, dTAF[[II]]250, DmelCG11154, growth of cell, cell, Absolute, ethanol, beta-ATPase, ATP MgCl2, chlorure de sodium, Metabolic Concept, Taf1p, Maintenances, dTAF250, C2H5OH, Candida robusta, Chromium Salt, ATPasebeta, sels, MnATP, ATPase beta, Kochsalz, TAF, ATPB, TAF[[II]]250, degradation, sales, Sprain, Magnesium Chloride, l(3)84Ab, BG:DS00004.13, Adenosine 5'-(tetrahydrogen triphosphate), Saccaromyces cerevisiae, Cell, dTAF230, Concept, Metabolic Phenomena, ATP-syn-B, Sccharomyces cerevisiae, Metabolism Concepts, cell expansion, Atriphos, ML-1, Temperatures, Natriumchlorid, p230, chemical analysis, Strain, Phenomena, alcool ethylique, TAF[[II]]250/230, TFIID, table salt, NaCl, metabolism, Breathing, Metabolic Phenomenon, Sal, Saccharomyces oviformis, Ethyl Alcohol, Taf[[II]]250, multicellular organism metabolic process, Manganese Adenosine Triphosphate, TAF[[II]]230, biodegradation, Metabolic, increased number, B130022O04Rik, TAF[II]250, Salze, Understanding, Age symptoms begin, sal, present in greater numbers in organism, hydroxyethane, DmelCG17603, Dietary Sodium, ATPIB, assay, response, Calcium Salt, TAF1, Anabolism"],"pubmed_title_synonyms":["biochemical pathways, Mitochondrial, multicellular organism metabolic process, Metabolic Process, biodegradation, Metabolic, degradation, Process, catabolism, Processes, metabolism resulting in cell growth, Metabolic Concepts, Metabolic Concept, metabolic process resulting in cell growth, Metabolic Processes, Anabolism., mitochondrial, Concept, Metabolic Phenomena, Metabolism Concepts, ATP synthase D chain, Metabolism, Phenomena, Concepts, biotransformation, secretion, Metabolism Concept, Phenomenon, Metabolism Phenomena, Catabolism, metabolism, Metabolic Phenomenon"],"additional_accession":[]},"is_claimable":false,"name":"Lahtvee2016 - Automatically generated model for S. cerevisiae - etoh40_3","description":"No 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