BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=PBPK_GSMN_NR.ctrl.txthttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=psp412230-sup-0001-suppinfo.pdfhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=spept2ode.pyhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=COMPILE.bathttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=qsspn.exehttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=HepatoNet1_EMM_14122016.sfbahttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=PBPK_GSMN_NR.spepthttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=CLEAN.bathttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=cygstdc++-6.dllhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=cygwin1.dllhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=cyggcc_s-seh-1.dllhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=RUN.bathttps://www.ebi.ac.uk/biomodels/model/download/MODEL2111050001?filename=PBPK_GSMN_NR.qsspnprimaryOK200Krishna Kumar TiwariNon-curatedconstraint-based model*TransQSThttps://www.ebi.ac.uk/biomodels/MODEL211105000128782239falseBioModelsModelsOtherMaldonado2017 Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics2017MODEL2111050001Elaina M MaldonadoElaina M Maldonado, Vytautas Leoncikas, Ciarán P Fisher, J Bernadette Moore, Nick Plant, Andrzej M Kierzek28782239, The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of metabolic enzymes expressed in human tissues. Dynamic models of the gene regulation of key drug metabolism enzymes are available. Here, we introduce GSMNs and review ongoing work on integration of PBPK, GSMNs, and metabolic gene regulation. We demonstrate example models.. 11, 6. School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK.ktiwari@ebi.ac.ukEMBL-EBIThe scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of metabolic enzymes expressed in human tissues. Dynamic models of the gene regulation of key drug metabolism enzymes are available. Here, we introduce GSMNs and review ongoing work on integration of PBPK, GSMNs, and metabolic gene regulation. We demonstrate example models.Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics.Maldonado Elaina M EM, Leoncikas Vytautas V, Fisher Ciarán P CP, Moore J Bernadette JB, Plant Nick J NJ, Kierzek Andrzej M AMfalseMaldonado2017 - Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based PharmacokineticsExample models of ongoing work on integration of PBPK, GSMNs, and metabolic gene regulation.2021-11-052021-11-052021-11-05MODEL211105000128782239MODEL2111050001