{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2310300002?filename=NothaGEM%20iSM1809.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2310300002?filename=NothaGEM%20iSM1809.zip"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Sarayu Murali"],"curationStatus":["Non-curated"],"modellingApproach":["constraint-based model"],"levelVersion":["L3V1"],"submitter_keywords":["FROG"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL2310300002"],"isPrivate":["false"],"repository":["BioModels"],"omics_type":["Models"],"modelFormat":["SBML"],"tokenised_name":["NothaGEM iSM1809"],"publication_year":["2023"],"submissionId":["MODEL2310300002"],"first_author":["Murali S"],"publication_authors":["Murali S, Ibrahim M, Rajendran H, Shagun S, Masakapalli SK, Raman K, Srivastava S"],"publication":["10.3389/fpls.2023.1207218,\n                            Camptothecin (CPT) is a vital monoterpene indole alkaloid used in anti-cancer therapeutics. It is primarily derived from <i>Camptotheca acuminata</i> and <i>Nothapodytes nimmoniana</i> plants that are indigenous to Southeast Asia. Plants have intricate metabolic networks and use them to produce secondary metabolites such as CPT, which is a prerequisite for rational metabolic engineering design to optimize their production. By reconstructing metabolic models, we can predict plant metabolic behavior, facilitating the selection of suitable approaches and saving time, cost, and energy, over traditional hit and trial experimental approaches. In this study, we reconstructed a genome-scale metabolic model for <i>N. nimmoniana</i> (NothaGEM <i>i</i>SM1809) and curated it using experimentally obtained biochemical data. We also used <i>in silico</i> tools to identify and rank suitable enzyme targets for overexpression and knockout to maximize camptothecin production. The predicted over-expression targets encompass enzymes involved in the camptothecin biosynthesis pathway, including strictosidine synthase and geraniol 10-hydroxylase, as well as targets related to plant metabolism, such as amino acid biosynthesis and the tricarboxylic acid cycle. The top-ranked knockout targets included reactions responsible for the formation of folates and serine, as well as the conversion of acetyl CoA and oxaloacetate to malate and citrate. One of the top-ranked overexpression targets, strictosidine synthase, was chosen to generate metabolically engineered cell lines of <i>N. nimmoniana</i> using <i>Agrobacterium tumefaciens-</i>mediated transformation. The transformed cell line showed a 5-fold increase in camptothecin production, with a yield of up to 5 µg g<sup>-1</sup>.. null, 14.\n                            Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India."],"submitter_mail":["msarayu.1993@gmail.com"],"publication_doi":["10.3389/fpls.2023.1207218"],"submitter_affiliation":["Indian Institute of Technology Madras"],"additional_accession":[]},"is_claimable":false,"name":"NothaGEM iSM1809","description":"No description","dates":{"last_modification":"2023-10-30","publication":"2023-10-31","submission":"2023-10-30"},"accession":"MODEL2310300002","cross_references":{"kegg__reaction":["R00115","R00248","R00253","R00118","R00509","R00127","R00710","R00256","R00511","R00734","R01073","R00512","R00258","R01082","R00130","R00514","R01083","R00131","R00742","R00519","R01086","R00259","R10092","R01121","R00533","R00277","R00751","R00754","R01123","R00137","R00548","R00278","R00155","R06211","R00842","R00549","R00286","R01127","R00156","R00289","R01130","R00897","R00551","R01135","R00330","R01137","R00569","R00905","R00158","R00570","R00939","R00159","R00332","R00942","R00341","R00160","R01163","R01220","R00342","R00161","R00573","R00943","R00945","R00173","R01221","R00582","R00004","R00174","R01226","R00352","R00586","R00946","R00355","R00177","R01229","R01231","R00588","R00963","R00179","R01248","R00589","R00009","R00965","R00185","R00369","R00616","R00966","R01251","R00189","R00618","R00978","R00190","R00014","R00619","R00996","R00199","R00649","R00372","R00200","R01268","R01015","R00024","R00650","R01270","R00652","R00206","R01274","R00066","R00654","R01049","R01280","R00214","R00658","R00093","R00216","R00103","R00405","R01056","R00424","R01301","R00221","R00694","R00425","R00104","R00224","R01325","R00451","R00235","R01058","R00472","R00105","R00238","R01061","R00475","R01333","R00697","R00112","R00239","R01334","R00703","R00480","R00481","R01398","R01381","R01063","R01870","R01401","R01384","R01909","R01071","R02300","R00486","R01512","R01386","R01072","R02301","R03269","R01912","R04426","R01388","R02323","R03313","R01513","R01942","R04448","R01514","R02324","R01397","R04457","R01943","R01518","R03314","R02326","R04463","R01954","R01978","R01523","R01993","R04509","R01528","R04558","R04559","R02003","R02331","R03321","R02035","R04560","R01529","R04591","R01600","R03347","R04621","R02061","R01613","R03348","R04638","R04640","R02379","R03366","R05612","R08836","R02385","R01615","R03443","R02082","R01616","R02412","R03457","R02413","R01641","R03458","R05613","R02092","R01652","R07475","R02416","R03459","R01655","R02442","R03460","R02472","R02093","R03471","R02473","R05633","R03503","R01658","R05634","R02493","R05636","R03504","R01663","R05637","R02521","R03508","R02094","R01708","R05688","R03524","R05700","R02593","R07440","R01712","R02095","R04724","R05701","R01714","R04958","R05717","R02594","R02100","R03605","R01715","R04955","R02634","R03918","R02101","R05884","R04954","R02649","R02135","R06572","R01716","R04965","R03968","R02735","R04568","R01717","R04001","R02736","R02193","R01722","R04953","R06576","R07437","R02194","R04534","R01724","R07168","R03005","R02245","R07219","R04964","R01737","R04031","R03012","R02253","R07262","R01773","R04566","R04035","R03035","R01775","R04960","R04037","R03067","R02254","R07263","R01826","R04726","R04143","R02255","R01829","R04952","R04144","R03083","R02269","R07273","R04963","R04173","R01845","R07280","R03084","R04957","R04198","R02282","R03140","R07281","R01626","R04199","R02283","R07364","R01857","R04208","R02291","R03182","R07392","R04209","R03210","R04292","R03223","R07393","R03231","R07394","R04325","R03243","R04342","R07432","R03245","R07442","R04420","R04014","R08209","R00267","R07613","R10707","R07765","R08648","R00479","R08549","R00709","R06073","R06088","R10221","R05553","R08163","R01070","R08165","R02199","R08166","R01080","R01090","R01092","R01184","R01214","R08210","R01286","R01476","R01786","R03018","R01788","R08174","R01830","R00691","R01900","R04231","R00351","R02073","R02237","R02595","R02740","R03920","R08747","R04779","R00557","R04780","R00667","R08782","R08767","R00959","R09451","R08755","R03472","R00707","R08754","R08756","R09453","R00226","R10089","R09461","R00685","R08396","R00643","R08785","R09928","R00674","R09929","R10709","R01827","R00733","R01245","R07267","R05832","R03554","R00529","R03555","R03738","R08487","R08488","R02167","R08489","R00758","R08490","R00343","R02739","R00251","R07500","R07501","R05611","R07276","R07502","R01213","R00986","R07236","R03013","R02065","R03509","R01602","R04218","R09652","R09655","R02340","R07512","R05341","R03824","R00794","R06284","R01819","R00889","R01818","R00885","R00291","R07678","R01402","R07675","R07674","R00640","R09542","R00017","R02506","R00081","R03604","R01324","R01945","R00578","R01771","R01466","R05070","R00192","R01289","R01001","R01283","R00651","R03217","R01138","R00086"],"seed__compound":["cpd00013","cpd00018","cpd00033","cpd00014","cpd00052","cpd00001","cpd00040","cpd00062","cpd00009","cpd00096","cpd00355","cpd00146","cpd00023","cpd00012","cpd00132","cpd00067","cpd00010","cpd00053","cpd00054","cpd00002","cpd00036","cpd00015","cpd00035","cpd00738","cpd00006","cpd00078","cpd00050","cpd00008","cpd00047","cpd00024","cpd00722","cpd02978","cpd00020","cpd00016","cpd00022","cpd00004","cpd00215","cpd00957","cpd00005","cpd00039","cpd00516","cpd00477","cpd00145","cpd00017","cpd00493","cpd00056","cpd00060","cpd00139","cpd00007","cpd01937","cpd00025","cpd00305","cpd00042","cpd01977","cpd02027","cpd00111","cpd00478","cpd03470","cpd00869","cpd00026","cpd00094","cpd00144","cpd00147","cpd00324","cpd01651","cpd00089","cpd00909","cpd00482","cpd00182","cpd00031","cpd00044","cpd00038","cpd00193","cpd00638","cpd00103","cpd00029","cpd00128","cpd00011","cpd00064","cpd00019","cpd00046","cpd00066","cpd00135","cpd00143","cpd00367","cpd03049","cpd00061","cpd00003","cpd00126","cpd00032","cpd00048","cpd00130","cpd00655","cpd00081","cpd00333","cpd00169","cpd00159","cpd00871","cpd00550","cpd00071","cpd00220","cpd00051","cpd00073","cpd00242","cpd00069","cpd00868","cpd02656","cpd00137","cpd00279","cpd02882","cpd00091","cpd00041","cpd02097","cpd00070","cpd00161","cpd00347","cpd00101","cpd00284","cpd00123","cpd00363","cpd00295","cpd00171","cpd00075","cpd00712","cpd00241","cpd00298","cpd00209","cpd00357","cpd00198","cpd00076","cpd00207","cpd00358","cpd01693","cpd00190","cpd00129","cpd00793","cpd00080","cpd00863","cpd00203","cpd02431","cpd00095","cpd00192","cpd03969","cpd01733","cpd00084","cpd01059","cpd00133","cpd00247","cpd00239","cpd00812","cpd00218","cpd02479","cpd00102","cpd00270","cpd00134","cpd01775","cpd00321","cpd00214","cpd01982","cpd00604","cpd00881","cpd01224","cpd00093","cpd00085","cpd00248","cpd02642","cpd00422","cpd00634","cpd01720","cpd03332","cpd00337","cpd00106","cpd00087","cpd00292","cpd00330","cpd00282","cpd00238","cpd02375","cpd00343","cpd00200","cpd00342","cpd02152","cpd06227","cpd02605","cpd00918","cpd00113","cpd00350","cpd00201","cpd00346","cpd00911","cpd00841","cpd00283","cpd02120","cpd00289","cpd00136","cpd02197","cpd00125","cpd01892","cpd00202","cpd00206","cpd00331","cpd00299","cpd02016","cpd00345","cpd00263","cpd00356","cpd00533","cpd00419","cpd00114","cpd00291","cpd00216","cpd02884","cpd00932","cpd02914","cpd00229","cpd00332","cpd00727","cpd00497","cpd00219","cpd00115","cpd00249","cpd00880","cpd00177","cpd08210","cpd00810","cpd00163","cpd00658","cpd01140","cpd00297","cpd01926","cpd00978","cpd00092","cpd00873","cpd00223","cpd00222","cpd00227","cpd00274","cpd00236","cpd01981","cpd02857","cpd00809","cpd00119","cpd02069","cpd01324","cpd00349","cpd00373","cpd00383","cpd00858","cpd03337","cpd02595","cpd02030","cpd00374","cpd02791","cpd00065","cpd01716","cpd01761","cpd02636","cpd02654","cpd01890","cpd00099","cpd11225","cpd02678","cpd02826","cpd00398","cpd00072","cpd02851","cpd03344","cpd02991","cpd01335","cpd00408","cpd03471","cpd02921","cpd00644","cpd03846","cpd00156","cpd02333","cpd15560","cpd03521","cpd15561","cpd00906","cpd00426","cpd11477","cpd02590","cpd15277","cpd02843","cpd00458","cpd00931","cpd01260","cpd00327","cpd01741","cpd11468","cpd02720","cpd11469","cpd00939","cpd11470","cpd01080","cpd02775","cpd02591","cpd11471","cpd01107","cpd00954","cpd11472","cpd00565","cpd03128","cpd11473","cpd00472","cpd02961","cpd08286","cpd02497","cpd00956","cpd11479","cpd08287","cpd11480","cpd02210","cpd02552","cpd08288","cpd00150","cpd00504","cpd11467","cpd08289","cpd11484","cpd11486","cpd00322","cpd08301","cpd01082","cpd00641","cpd11482","cpd00834","cpd01554","cpd00260","cpd11487","cpd08615","cpd00443","cpd03333","cpd11489","cpd00683","cpd08984","cpd11491","cpd11488","cpd02920","cpd11492","cpd00107","cpd01646","cpd11493","cpd01710","cpd02295","cpd11464","cpd02693","cpd11217","cpd11474","cpd01722","cpd00699","cpd11490","cpd00204","cpd02021","cpd00764","cpd01772","cpd01311","cpd03451","cpd00782","cpd01777","cpd00800","cpd02172","cpd01695","cpd02979","cpd02419","cpd00424","cpd03847","cpd02574","cpd00790","cpd11255","cpd02394","cpd11295","cpd02465","cpd02894","cpd02140","cpd11296","cpd02893","cpd02701","cpd12458","cpd00205","cpd00807","cpd14940","cpd00930","cpd02201","cpd00498","cpd00536","cpd02666","cpd16638","cpd16335","cpd19006","cpd27743","cpd27735","cpd05238","cpd28068","cpd16503","cpd28060","cpd16346","cpd00109","cpd19035","cpd11416","cpd00110","cpd02428","cpd00059","cpd28294","cpd03091","cpd01420","cpd23602","cpd19486","cpd01628","cpd12844","cpd25615","cpd00318","cpd26730","cpd00616","cpd20674","cpd26869","cpd20873","cpd02746","cpd01062","cpd27666","cpd28273","cpd17740","cpd24684","cpd27757","cpd28082","cpd24685","cpd21456","cpd24686","cpd02738","cpd05229","cpd17741","cpd03148","cpd33689","cpd20874","cpd23695","cpd00418","cpd35211","cpd27764","cpd26827","cpd03617","cpd11632","cpd25048","cpd25924","cpd24956","cpd17691","cpd08447","cpd25882","cpd17569","cpd00235","cpd01069","cpd07334","cpd27437","cpd17570","cpd01023","cpd25087","cpd30761","cpd03214","cpd01275","cpd27746","cpd11485","cpd22416","cpd19047","cpd02193","cpd27551","cpd22419","cpd27796","cpd00353","cpd28024","cpd16527","cpd27797","cpd28473","cpd16526","cpd27884","cpd24737","cpd16528","cpd14938","cpd25914","cpd01304","cpd28030","cpd00481","cpd01122","cpd22418","cpd14613","cpd01398","cpd22077","cpd19001","cpd14614","cpd27830","cpd30321","cpd01631","cpd00104","cpd16443","cpd02168","cpd03211","cpd27763","cpd20867","cpd05196","cpd25885","cpd27765","cpd03215","cpd20868","cpd16343","cpd25887","cpd27716","cpd14588","cpd28012","cpd25895","cpd22445","cpd21005","cpd25897","cpd26755","cpd28011","cpd22021","cpd14589","cpd28013","cpd28023","cpd03217","cpd00359","cpd03220","cpd19036","cpd27355","cpd02535","cpd27847","cpd20869","cpd01536","cpd20870","cpd00348","cpd00485","cpd20871","cpd00724","cpd14655","cpd22504","cpd00508","cpd00121","cpd00083","cpd26630","cpd05264","cpd01257","cpd00820","cpd24597","cpd00971","cpd16441","cpd30797","cpd19019","cpd00254","cpd00058","cpd00063","cpd00034","cpd00149","cpd00030","cpd10515","cpd27436","cpd00314","cpd01293","cpd01449","cpd00670","cpd00311"],"sbo":["SBO:0000247","SBO:0000176","SBO:0000185","SBO:0000627","SBO:0000629"],"seed__reaction":["rxn00086","rxn00184","rxn00187","rxn00088","rxn00361","rxn00097","rxn00506","rxn00189","rxn00363","rxn00527","rxn00364","rxn00791","rxn00191","rxn00799","rxn00366","rxn00100","rxn00800","rxn00101","rxn00533","rxn00371","rxn00802","rxn00192","rxn00102","rxn00829","rxn00541","rxn00383","rxn00208","rxn00543","rxn00105","rxn00830","rxn00391","rxn00571","rxn00209","rxn00116","rxn00578","rxn00611","rxn00211","rxn00392","rxn00832","rxn00117","rxn00213","rxn00834","rxn00649","rxn00394","rxn00237","rxn00838","rxn00839","rxn00408","rxn00654","rxn00119","rxn00686","rxn00409","rxn00120","rxn00239","rxn00689","rxn00121","rxn00247","rxn00863","rxn00907","rxn00248","rxn00122","rxn00412","rxn00690","rxn00414","rxn00692","rxn00416","rxn00123","rxn00908","rxn00420","rxn00001","rxn00124","rxn00912","rxn00257","rxn00423","rxn00693","rxn00260","rxn00126","rxn00915","rxn00917","rxn00424","rxn00708","rxn00128","rxn00929","rxn00425","rxn00710","rxn00006","rxn00134","rxn00272","rxn00437","rxn00711","rxn00138","rxn00931","rxn00439","rxn00720","rxn00011","rxn00139","rxn00440","rxn00147","rxn00737","rxn00937","rxn00451","rxn00275","rxn00747","rxn00148","rxn00018","rxn00938","rxn00452","rxn00940","rxn00454","rxn00943","rxn00151","rxn00048","rxn00456","rxn00159","rxn00770","rxn00947","rxn00069","rxn00459","rxn00161","rxn00285","rxn00076","rxn00777","rxn00299","rxn00965","rxn00166","rxn00493","rxn00077","rxn00300","rxn00974","rxn00168","rxn00313","rxn00175","rxn00779","rxn00330","rxn00078","rxn00178","rxn00781","rxn00333","rxn00979","rxn00495","rxn00083","rxn00179","rxn00980","rxn00337","rxn00499","rxn00338","rxn01019","rxn01005","rxn01362","rxn00782","rxn01021","rxn01007","rxn01396","rxn00789","rxn01652","rxn00343","rxn01100","rxn01009","rxn00790","rxn01653","rxn02341","rxn01399","rxn03062","rxn01011","rxn01670","rxn02373","rxn01101","rxn01426","rxn03075","rxn01671","rxn01102","rxn03080","rxn01018","rxn01427","rxn01106","rxn02374","rxn01673","rxn05218","rxn03084","rxn01434","rxn01454","rxn01111","rxn05220","rxn03108","rxn01465","rxn01115","rxn03135","rxn01466","rxn05222","rxn03136","rxn01678","rxn02380","rxn03137","rxn01476","rxn01116","rxn03147","rxn01169","rxn05224","rxn02401","rxn01486","rxn03168","rxn01179","rxn02402","rxn03173","rxn05238","rxn03175","rxn01712","rxn02414","rxn03891","rxn01718","rxn01494","rxn01181","rxn05245","rxn02465","rxn01501","rxn01739","rxn01182","rxn02473","rxn01740","rxn01200","rxn02474","rxn03892","rxn01511","rxn01743","rxn01208","rxn05287","rxn02475","rxn01211","rxn01765","rxn02476","rxn01512","rxn01790","rxn02484","rxn03907","rxn01791","rxn02503","rxn01213","rxn03908","rxn01807","rxn03909","rxn05319","rxn02504","rxn01217","rxn03910","rxn01827","rxn02507","rxn01249","rxn01513","rxn03958","rxn02516","rxn03970","rxn01887","rxn02554","rxn01253","rxn01514","rxn05324","rxn03971","rxn01255","rxn03983","rxn05325","rxn01888","rxn01519","rxn02575","rxn05326","rxn01256","rxn01909","rxn02758","rxn01520","rxn05330","rxn04113","rxn01917","rxn01539","rxn04426","rxn05331","rxn01257","rxn02789","rxn01974","rxn05335","rxn01258","rxn01975","rxn02811","rxn01570","rxn05337","rxn01263","rxn04430","rxn02814","rxn01571","rxn04954","rxn05338","rxn01265","rxn02155","rxn01607","rxn05340","rxn04996","rxn01275","rxn02832","rxn02159","rxn01611","rxn05023","rxn01301","rxn05342","rxn02834","rxn02175","rxn01302","rxn05343","rxn02835","rxn02201","rxn01612","rxn01332","rxn05024","rxn05345","rxn02894","rxn01613","rxn01334","rxn05346","rxn02895","rxn02212","rxn01626","rxn05034","rxn05348","rxn02914","rxn01345","rxn02213","rxn05039","rxn05350","rxn02928","rxn01636","rxn02251","rxn05040","rxn05465","rxn02929","rxn01637","rxn01353","rxn05467","rxn05092","rxn02937","rxn02277","rxn01643","rxn05104","rxn02938","rxn02297","rxn02988","rxn05468","rxn02305","rxn01644","rxn05105","rxn02312","rxn05106","rxn03004","rxn02320","rxn05736","rxn03016","rxn05136","rxn08747","rxn02322","rxn05667","rxn05143","rxn03057","rxn05206","rxn08749","rxn06556","rxn09444","rxn10929","rxn08756","rxn15022","rxn17428","rxn07441","rxn08766","rxn10952","rxn17464","rxn07579","rxn08786","rxn09449","rxn17469","rxn08043","rxn17731","rxn10967","rxn08104","rxn09453","rxn15045","rxn08155","rxn17745","rxn17746","rxn08856","rxn11013","rxn17803","rxn15056","rxn09686","rxn18935","rxn15062","rxn18936","rxn15069","rxn08920","rxn11040","rxn18937","rxn09711","rxn08170","rxn19027","rxn19071","rxn08999","rxn09717","rxn11700","rxn08173","rxn09736","rxn15116","rxn19077","rxn08233","rxn11702","rxn09005","rxn19240","rxn08236","rxn11703","rxn15118","rxn09777","rxn12282","rxn15121","rxn19241","rxn09034","rxn08284","rxn09784","rxn09048","rxn15151","rxn08335","rxn12329","rxn09785","rxn19242","rxn08352","rxn12426","rxn15166","rxn09050","rxn08392","rxn09118","rxn09792","rxn15209","rxn08436","rxn09794","rxn15249","rxn08440","rxn12510","rxn19246","rxn15250","rxn09121","rxn13149","rxn08444","rxn09817","rxn08525","rxn13213","rxn15271","rxn09839","rxn19253","rxn13290","rxn15280","rxn19277","rxn09177","rxn13360","rxn09193","rxn19316","rxn10480","rxn08556","rxn13361","rxn08633","rxn19343","rxn15298","rxn09248","rxn13365","rxn19488","rxn19544","rxn08680","rxn15348","rxn10826","rxn09272","rxn13689","rxn15364","rxn09275","rxn19686","rxn13726","rxn19701","rxn08689","rxn13822","rxn19771","rxn15435","rxn10832","rxn19828","rxn08703","rxn09300","rxn14012","rxn08704","rxn09307","rxn10867","rxn19900","rxn08721","rxn15493","rxn10923","rxn09339","rxn20176","rxn14058","rxn08730","rxn15494","rxn20496","rxn20508","rxn09366","rxn20617","rxn14085","rxn15780","rxn20583","rxn25743","rxn20643","rxn14094","rxn16289","rxn25747","rxn14142","rxn29318","rxn20649","rxn20595","rxn25750","rxn21324","rxn14261","rxn25762","rxn16291","rxn15021","rxn29325","rxn21635","rxn32628","rxn16300","rxn25847","rxn33186","rxn25848","rxn22111","rxn29342","rxn34362","rxn25977","rxn17196","rxn22116","rxn34364","rxn22957","rxn35347","rxn17206","rxn29733","rxn00484","rxn37018","rxn25978","rxn23772","rxn23773","rxn00058","rxn37266","rxn25982","rxn12058","rxn23801","rxn00445","rxn26013","rxn14390","rxn29785","rxn37324","rxn26037","rxn16768","rxn23805","rxn16769","rxn29919","rxn24109","rxn42507","rxn24131","rxn30639","rxn37585","rxn26477","rxn24210","rxn26754","rxn37610","rxn27029","rxn25524","rxn24286","rxn31154","rxn27030","rxn04065","rxn24310","rxn31160","rxn27259","rxn24312","rxn02535","rxn37651","rxn31167","rxn24330","rxn37695","rxn02536","rxn37784","rxn02655","rxn24348","rxn27266","rxn31168","rxn12131","rxn38788","rxn24358","rxn12132","rxn24360","rxn27318","rxn01560","rxn38795","rxn31169","rxn24362","rxn12133","rxn39241","rxn00546","rxn24404","rxn12134","rxn24411","rxn05617","rxn27360","rxn24412","rxn31240","rxn39242","rxn24508","rxn01487","rxn31358","rxn00186","rxn27415","rxn24928","rxn07331","rxn31768","rxn25371","rxn27497","rxn07332","rxn39243","rxn25441","rxn07333","rxn27709","rxn25468","rxn05004","rxn27927","rxn25469","rxn31828","rxn39244","rxn28082","rxn25475","rxn01489","rxn39245","rxn25480","rxn28083","rxn08643","rxn39246","rxn25630","rxn02945","rxn31927","rxn28487","rxn39247","rxn25637","rxn32037","rxn16495","rxn28606","rxn25641","rxn39248","rxn16498","rxn28615","rxn25647","rxn39249","rxn31006","rxn29086","rxn25649","rxn32435","rxn39250","rxn31007","rxn39251","rxn25661","rxn07343","rxn39252","rxn25662","rxn39253","rxn32592","rxn03646","rxn29122","rxn25716","rxn11574","rxn25718","rxn29240","rxn39254","rxn25719","rxn24357","rxn32839","rxn39255","rxn04161","rxn00641","rxn29246","rxn00840","rxn32662","rxn15270","rxn00340","rxn27702","rxn01329","rxn15229","rxn00643","rxn00913","rxn11026","rxn01354","rxn07493","rxn01219","rxn01333","rxn07490","rxn07489","rxn00536","rxn15412","rxn00443","rxn23803","rxn19192","rxn00014","rxn03990","rxn01815","rxn05036","rxn00490","rxn11201","rxn01429","rxn00341","rxn01603","rxn01300","rxn01069","rxn08764","rxn03437","rxn01575","rxn00141","rxn00953","rxn00742","rxn00949","rxn00453","rxn02302","rxn00365","rxn00062"],"kegg__compound":["C00037","C00063","C00015","C00014","C00020","C00075","C00001","C00048","C00112","C00009","C00455","C00169","C00013","C00025","C00152","C00080","C00010","C00064","C00065","C00002","C00042","C00016","C00041","C00006","C01005","C00061","C00091","C00008","C00058","C00026","C00979","C04895","C00018","C00022","C00024","C00004","C00250","C01304","C00005","C00047","C00680","C00624","C00168","C00019","C00647","C00068","C00073","C00160","C00007","C03028","C00027","C00378","C00051","C03082","C03172","C00127","C00627","C05840","C01180","C00029","C00109","C00167","C00170","C00409","C02512","C01234","C00103","C00631","C00053","C00035","C00212","C00044","C00224","C00857","C00119","C00033","C00147","C00077","C00011","C00021","C00079","C00055","C00155","C00475","C00166","C05125","C00074","C00003","C00144","C00036","C00149","C00059","C00882","C00094","C00423","C00197","C00186","C01182","C00740","C00084","C00255","C00086","C00062","C00288","C00082","C01179","C04332","C00158","C00332","C04732","C00105","C00049","C03287","C00083","C00117","C00188","C00445","C00345","C00469","C00141","C00361","C00199","C00088","C00966","C00364","C00286","C00244","C00459","C00089","C00231","C00460","C00242","C02591","C00221","C00148","C01081","C00093","C01172","C00236","C03912","C00111","C00223","C06561","C02666","C00097","C01494","C00295","C00283","C00153","C01107","C00253","C03996","C00118","C00323","C00154","C02739","C00249","C00406","C03090","C00811","C01197","C00108","C01772","C00099","C00296","C00540","C04302","C02642","C00852","C05608","C00122","C00429","C00101","C00356","C00415","C00337","C05382","C03794","C00438","C00233","C00437","C03406","C04236","C03541","C01250","C00129","C00448","C00234","C00441","C01143","C01236","C00341","C03340","C00353","C00156","C03479","C00143","C02949","C00239","C00235","C00417","C00365","C03150","C00440","C00314","C00458","C00705","C00534","C00355","C00130","C00251","C04734","C04796","C00266","C01269","C00988","C00418","C00655","C00254","C00131","C00299","C05385","C00206","C11355","C01103","C00190","C00885","C01623","C00363","C03003","C01346","C00106","C01185","C00258","C00257","C00263","C00327","C00279","C03089","C04691","C01102","C00135","C03232","C01929","C00447","C00482","C00493","C01165","C05619","C12208","C03175","C00483","C04582","C00078","C02637","C02717","C04294","C04327","C02947","C00698","C15556","C04376","C04640","C00509","C00085","C04677","C05631","C04916","C00522","C01944","C05841","C04823","C00864","C06423","C00183","C03722","C17569","C05925","C01230","C00544","C05763","C04216","C04666","C00590","C01268","C01832","C00412","C05223","C04454","C02679","C05758","C01279","C01530","C05752","C04556","C04217","C05751","C01571","C01300","C05749","C05274","C00761","C04874","C05748","C00617","C11434","C01302","C04037","C05747","C11435","C04133","C05757","C03506","C11436","C00177","C00666","C05760","C11437","C04688","C05746","C00407","C11453","C01533","C00860","C04619","C02325","C00311","C01134","C05753","C05610","C11811","C00568","C05756","C00921","C12204","C05759","C05744","C04807","C01209","C00123","C02504","C00229","C02631","C03657","C05745","C04411","C15547","C05755","C02646","C00944","C05750","C00237","C01037","C03160","C02730","C01909","C05817","C01063","C02741","C01092","C04145","C02593","C04896","C03885","C00542","C06424","C04188","C01077","C15606","C03838","C15650","C03972","C04752","C03373","C15651","C04751","C04425","C04088","C01100","C00238","C16221","C01267","C03492","C00659","C00712","C04352","C16519","C00668","C08323","C16695","C16532","C00125","C05345","C03906","C00126","C00072","C02094","C05198","C02477","C18218","C03313","C00398","C00826","C19418","C04509","C19620","C01500","C17621","C20223","C04489","C08314","C17622","C05306","C19621","C00533","C06070","C00205","C20789","C17570","C11636","C00275","C17439","C01512","C10448","C17440","C01433","C04146","C05427","C01852","C05762","C06010","C03470","C00451","C16724","C10385","C16723","C16725","C16219","C01897","C00630","C01595","C15882","C02050","C00267","C15883","C02336","C02483","C00120","C16639","C03427","C05421","C19614","C08281","C05430","C19615","C16528","C15857","C19759","C15858","C05432","C00463","C05435","C05378","C04104","C19616","C02280","C19617","C00446","C00636","C19618","C00984","C15926","C00671","C00137","C20784","C00096","C08350","C01825","C01115","C01330","C16637","C02291","C00305","C00076","C00038","C00175","C19610","C14818","C00644","C00392","C01879","C02139","C00903","C00387"],"doi":["10.3389/fpls.2023.1207218"]}}