{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2312190001?filename=ford20.pdf"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2312190001?filename=ford20.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL2312190001?filename=ford20_sedml.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2312190001?filename=ford20.saam"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Kieran Smallbone"],"curationStatus":["Non-curated"],"modellingApproach":["differential equation model"],"levelVersion":["L3V2"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL2312190001"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Ford2020   whole body vitamin A metabolism in humans"],"publication_year":["2020"],"submissionId":["MODEL2312190001"],"publication_authors":["Jennifer Lynn Ford, Joanne Balmer Green, Marjorie J Haskell, Shaikh M Ahmad, Dora Inés Mazariegos Cordero, Anthony Oxley, Reina Engle-Stone, Georg Lietz, Michael H Green"],"first_author":["Jennifer Lynn Ford"],"publication":["10.1093/jn/nxz225,\n                            Background\n\nModel-based compartmental analysis has been used to describe and quantify whole-body vitamin A metabolism and estimate total body stores (TBS) in animals and humans.\n\nObjectives\n\nWe applied compartmental modeling and a super-child design to estimate retinol kinetic parameters and TBS for young children in Bangladesh, Guatemala, and the Philippines.\n\nMethods\n\nChildren ingested [13C10]retinyl acetate and 1 or 2 blood samples were collected from each child from 6 h to 28 d after dosing. Temporal data for fraction of dose in plasma [13C10]retinol were modeled using WinSAAM software and a 6-component model with vitamin A intake included as weighted data.<h4>Results</h4>Model-predicted TBS was 198, 533, and 1062 μmol for the Bangladeshi (age, 9-17 mo), Filipino (12-18 mo), and Guatemalan children (35-65 mo). Retinol kinetics were similar for Filipino and Guatemalan groups and generally faster for Bangladeshi children, although fractional transfer of plasma retinol to a larger exchangeable storage pool was the same for the 3 groups. Recycling to plasma from that pool was ∼2.5 times faster in the Bangladeshi children compared with the other groups and the recycling number was 2-3 times greater. Differences in kinetics between groups are likely related to differences in vitamin A stores and intakes (geometric means: 352, 727, and 764 μg retinol activity equivalents/d for the Bangladeshi, Filipino, and Guatemalan children, respectively).\n\nConclusions\n\nBy collecting 1 or 2 blood samples from each child to generate a composite plasma tracer data set with a minimum of 5 children/time, group TBS and retinol kinetics can be estimated in children by compartmental analysis; inclusion of vitamin A intake data increases confidence in model predictions. The super-child modeling approach is an effective technique for comparing vitamin A status among children from different populations. These trials were registered at www.clinicaltrials.gov as NCT03000543 (Bangladesh), NCT03345147 (Guatemala), and NCT03030339 (Philippines).. 2, 150.\n                            Pennsylvania State University"],"submitter_mail":["kieran.smallbone@ncl.ac.uk"],"publication_doi":["10.1093/jn/nxz225"],"submitter_affiliation":["Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK."],"additional_accession":[]},"is_claimable":false,"name":"Ford2020 - whole-body vitamin A metabolism in humans","description":"No description","dates":{"last_modification":"2024-05-22","publication":"2024-03-01","submission":"2023-12-19"},"accession":"MODEL2312190001","cross_references":{"chebi":["CHEBI:50211"],"mamo":["MAMO:0000045","MAMO:0000046"],"biomodels__db":["MODEL2312190001"],"go":["GO:0006776"],"taxonomy":["9606"],"doi":["10.1093/jn/nxz225"]}}