BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2312190001?filename=ford20.pdfhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2312190001?filename=ford20.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2312190001?filename=ford20_sedml.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2312190001?filename=ford20.saamprimaryOK200Kieran SmallboneNon-curateddifferential equation modelL3V2https://www.ebi.ac.uk/biomodels/MODEL2312190001falseBioModelsSBMLModelsFord2020 whole body vitamin A metabolism in humans2020MODEL2312190001Jennifer Lynn Ford, Joanne Balmer Green, Marjorie J Haskell, Shaikh M Ahmad, Dora Inés Mazariegos Cordero, Anthony Oxley, Reina Engle-Stone, Georg Lietz, Michael H GreenJennifer Lynn Ford10.1093/jn/nxz225, Background Model-based compartmental analysis has been used to describe and quantify whole-body vitamin A metabolism and estimate total body stores (TBS) in animals and humans. Objectives We applied compartmental modeling and a super-child design to estimate retinol kinetic parameters and TBS for young children in Bangladesh, Guatemala, and the Philippines. Methods Children ingested [13C10]retinyl acetate and 1 or 2 blood samples were collected from each child from 6 h to 28 d after dosing. Temporal data for fraction of dose in plasma [13C10]retinol were modeled using WinSAAM software and a 6-component model with vitamin A intake included as weighted data.<h4>Results</h4>Model-predicted TBS was 198, 533, and 1062 μmol for the Bangladeshi (age, 9-17 mo), Filipino (12-18 mo), and Guatemalan children (35-65 mo). Retinol kinetics were similar for Filipino and Guatemalan groups and generally faster for Bangladeshi children, although fractional transfer of plasma retinol to a larger exchangeable storage pool was the same for the 3 groups. Recycling to plasma from that pool was ∼2.5 times faster in the Bangladeshi children compared with the other groups and the recycling number was 2-3 times greater. Differences in kinetics between groups are likely related to differences in vitamin A stores and intakes (geometric means: 352, 727, and 764 μg retinol activity equivalents/d for the Bangladeshi, Filipino, and Guatemalan children, respectively). Conclusions By collecting 1 or 2 blood samples from each child to generate a composite plasma tracer data set with a minimum of 5 children/time, group TBS and retinol kinetics can be estimated in children by compartmental analysis; inclusion of vitamin A intake data increases confidence in model predictions. The super-child modeling approach is an effective technique for comparing vitamin A status among children from different populations. These trials were registered at www.clinicaltrials.gov as NCT03000543 (Bangladesh), NCT03345147 (Guatemala), and NCT03030339 (Philippines).. 2, 150. Pennsylvania State Universitykieran.smallbone@ncl.ac.uk10.1093/jn/nxz225Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK.falseFord2020 - whole-body vitamin A metabolism in humansNo description2024-05-222024-03-012023-12-19MODEL2312190001CHEBI:50211MAMO:0000045MAMO:0000046MODEL2312190001GO:0006776960610.1093/jn/nxz225