{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2402290003?filename=iRV973.xml"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Romeu Viana"],"curationStatus":["Non-curated"],"modellingApproach":["constraint-based model"],"levelVersion":["L3V2"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL2402290003"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["model iRV973 Cauris2023"],"publication_year":["2023"],"submissionId":["MODEL2402290003"],"publication_authors":["Romeu Viana, Tiago Carreiro, Diogo Couceiro, Oscar Dias, Isabel Rocha, Miguel Cacho Teixeira"],"first_author":["Romeu Viana"],"publication":["10.1093/femsyr/foad045,\n                            Candida auris is an emerging human pathogen, associated with antifungal drug resistance and hospital candidiasis outbreaks. In this work, we present iRV973, the first reconstructed Genome-scale metabolic model (GSMM) for C. auris. The model was manually curated and experimentally validated, being able to accurately predict the specific growth rate of C. auris and the utilization of several sole carbon and nitrogen sources. The model was compared to GSMMs available for other pathogenic Candida species and exploited as a platform for cross-species comparison, aiming the analysis of their metabolic features and the identification of potential new antifungal targets common to the most prevalent pathogenic Candida species. From a metabolic point of view, we were able to identify unique enzymes in C. auris in comparison with other Candida species, which may represent unique metabolic features. Additionally, 50 enzymes were identified as potential drug targets, given their essentiality in conditions mimicking human serum, common to all four different Candida models analysed. These enzymes represent interesting drug targets for antifungal therapy, including some known targets of antifungal agents used in clinical practice, but also new potential drug targets without any human homolog or drug association in Candida species.. , 23.\n                            Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisboa, Portugal."],"submitter_mail":["romeuviana@outlook.com"],"publication_doi":["10.1093/femsyr/foad045"],"submitter_affiliation":["Instituto Superior Técnico, Universidade de Lisboa"],"description_synonyms":["Candida auris, scale tissue, Targeting, human being, Man (Taxonomy), scale, Genomes, Drug Targeting, Drug Delivery, plant peltate hair, System, peltate hair, Modern, whole genome, man, Delivery System, human, Drug., Targetings, Human, Drug, Delivery Systems, C auris, Drug Delivery System, Homo sapiens, Modern Man, Systems, scales, Drug Targetings, Man"],"additional_accession":[]},"is_claimable":false,"name":"model_iRV973_Cauris2023","description":"Genome-scale metabolic model of Human pathogen Candida auris, used for drug targeting 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