{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2408120001?filename=Frog_Report.pdf"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2408120001?filename=iMS7199.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2408120001?filename=model.omex"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Oscar Dias"],"curationStatus":["Non-curated"],"modellingApproach":["constraint-based model"],"levelVersion":["L3V1"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL2408120001"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["iMS7199   genome scale metabolic model of Vitis vinifera"],"publication_year":["2024"],"submissionId":["MODEL2408120001"],"publication_authors":["Marta Sampaio, Miguel Rocha, Oscar Dias"],"first_author":["Marta Sampaio"],"publication":["10.1101/2024.01.30.578056,\n                            Vitis vinifera , also known as grapevine, is widely cultivated and commercialized, particularly to produce wine. As wine quality is directly linked to fruit quality, studying grapevine metabolism is important to understand the processes underlying grape composition. Genome-scale metabolic models (GSMMs) have been used for the study of plant metabolism and advances have been made, allowing the integration of omics datasets with GSMMs. On the other hand, Machine learning (ML) has been used to analyze omics data, and while the combination of ML with GSMMs has shown promising results, it is still scarcely used to study plants. Here, the first GSSM of V. vinifera was reconstructed and validated, comprising 7199 genes, 5399 reactions, and 5141 metabolites across 8 compartments. Tissue-specific models for stem, leaf, and berry of the Cabernet Sauvignon cultivar were generated from the original model, through the integration of RNA-Seq data. These models have been merged into diel multi-tissue models to study the interactions between tissues at light and dark phases. The potential of combining ML with GSMMs was explored by using ML to analyze the fluxomics data generated by green and mature grape GSMMs, helping to understand the factors influencing grape quality at different developmental stages.. , .\n                            University of Minho"],"submitter_mail":["odias@deb.uminho.pt"],"publication_doi":["10.1101/2024.01.30.578056"],"submitter_affiliation":["Centre of Biological Engineering, University of Minho, Braga, Portugal."],"additional_accession":[]},"is_claimable":false,"name":"iMS7199 - genome-scale metabolic model of Vitis vinifera","description":"The first GSSM of V. vinifera was reconstructed and validated, comprising 7199 genes, 5399 reactions, and 5141 metabolites across 8 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