BioModelsapplication/xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061.pdfhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061-biopax3.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061-biopax2.owlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061_url.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061_urn.xmlhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061.mhttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061.xpphttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061.scihttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061.pnghttps://www.ebi.ac.uk/biomodels/model/download/MODEL2463576061?filename=MODEL2463576061.vcmlprimaryOK200Molecular Systems BiologyNon-curatedL2V1https://www.ebi.ac.uk/biomodels/MODEL246357606116729045falseBioModelsSBMLModelsOda2005 EGFR2005MODEL2463576061Non KineticKanae Oda, Yukiko Matsuoka, Akira Funahashi, Hiroaki KitanoKanae Oda16729045, The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow-tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well-defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).. null, 1. The Systems Biology Institute, Tokyo, Japan.msbforum@embo.orgNature Publishing GroupThe epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow-tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well-defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).A comprehensive pathway map of epidermal growth factor receptor signaling.Oda Kanae K, Matsuoka Yukiko Y, Funahashi Akira A, Kitano Hiroaki Hextent, AW488255, Sectors, Public Sectors, Tb11, YB, NetrinA, AUTSX5, number, D430049E23Rik, Copyrights, NOVH, CCN3, QM, FBXW4, netrin, Yb, Hek6, Cek6, Public Enterprise, Enterprises, CG2706, fs(1)M104, ENSMUSG00000074119, ERP, APUDoma, Erp, Elkh, Ebi, EBI, Public Domains, Tyrosine-protein kinase receptor EPH-2, EK6, SAP-2, Sap-2, IGFBP9, Public Enterprises, DmelCG4063, IBP-9, neuroendocrine tumour, Kiaa4053, 2.7.10.1, Solute carrier family 6 member 2, L10, Etrp, CT27014, NET1, SLC6A5, Tbl1, TBL1, NAT1, netA, NOVh, Enterprise, NET, Net, Elk, ELK, C130099E04Rik, completeness, Neuronally-expressed EPH-related tyrosine kinase, DmelCG2706, EPH tyrosine kinase 2, DXS648, SAP2, SMAP55, 9330129L11, neuroendocrine tumor, net, neuroendocrine neoplasm, presence., count in organism, Norepinephrine transporter, IGFBP-9, Public, Public Domain, Domains, EPH-like kinase 6, NOV, PlexA1, Domain, Data Base, Plxn1, CG4063, nov, hEK6, CG18657, E-2f, mKIAA4053, E-2g, fs(1)Y[b], l(2)k16213, DmelCG18657, Sector, EPHT2, C130088N23Rik, EG:95B7.8, 2600013D04Rik, PLXN1, DXS648E, netrin ADER/faint little ball, Elp-B1RB1, Elp, D-Egf, Wa5, l(2)09261, TGF-alpha receptor activity, ERBB, C-erb, dEGFR1, DEgfr, Elp-B1, der, DER1., Elp-1, mor1, Errb1, mENA, EK2-6, CG10079, PIG61, torpedo/egfr, epidermal growth factor receptor activity, wa2, DmelCG10079, epidermal growth factor-activated receptor activity, AI552599, c-erbB, EGFr, Egfr, torpedo/Egfr, EGF receptor activity, TOP, Egf-r, DER/top, d-egf-r, egfr, EGF-R, HD-33, El, top/DER, DER/EGFR, EGFR, EGfr, EgfR, dEgfr, DER flb, top, Torpedo/DER, ERBB1, wa-2, Torpedo/Egfr, flb, top/flb, Degfr, Egf, EFG-R, Errp, l(2)57EFa, Erbb, DEGFR, l(2)57DEFa, l(2)05351, Der, DER, 9030024J15Rik, D-EGFR, dEGFR, l(2)57Ea, transforming growth factor-alpha receptor activity, DmHD-33, DER/torpedo, HER1, NISBD2DER/faint little ball, Urogastrone Receptor, dmBest1, Activity, determination, methionine aminopeptidase activity, Laboratory, postnatal development, Elp-B1, der, Receptors, Elp-1, Errb1, growth and development, DmelCG6264, Epidermal Growth Factor Receptor Family Protein, JTK14, PIG61, ErbB-1, epidermal growth factor-activated receptor activity, AI552599, TGF alpha, ARB, 2, Software Engineering, Research Activity, d-egf-r, Laboratory Research, Computer Program, peptidase M activity, signal transduction by protein phosphorylation, adenomas, Priorities, rabGAPLP, L-methionine aminopeptidase activity, Biology, ErbB 1, Open, Computer Programs and Programming, RabGAP-5, Epidermal Growth Factor Receptor, Epidermal Growth Factor Receptor Kinase, flb, Proto oncogene c ErbB 1 Protein, TGF-alpha, RUSC3, ErbB Receptor, TIE, 9030024J15Rik, D-EGFR, Research Priority, NISBD2, single organism signaling, DER1, Elp, CG6264, Papers, EGF Receptors, Wa5, l(2)09261, DEgfr, HER Family Receptors, MYH-associated polyposis, signal transduction by conformational transition, autosomal recessive familial adenomatous polyposis, Maps, Research Priorities, CG10079, Source Softwares, signal transduction by trans-phosphorylation, Software Tools, Programs, Program, Computer Applications, torpedo/egfr, signaling cascade, tie-1, wa2, Computer Applications Software, Computer Applications Softwares, Softwares, TU15B, Urogastrone, autosomal recessive, dBest1, Research and Development, egfr, RUTBC3, Software Applications, HD-33, El, D430008P04Rik, Dialects, death rate, growth pattern, non-developmental growth, Source Software, DER/EGFR, EGFR, EGfr, EgfR, erbB 1 Proto Oncogene Protein, dEgfr, dbest1, TGF-alpha Receptor, DER flb, erbB-1 Proto-Oncogene Protein, Torpedo/Egfr, ErbB-1 Receptor, Degfr, RABGAP5, Activities, Receptor Tyrosine protein Kinase erbB 1, Applications, Transforming-Growth Factor alpha, signaling pathway, DEGFR, l(2)57DEFa, l(2)05351, multiple colorectal, dEGFR, HER, DmHD-33, Feedbacks, c-ErbB-1 Protein, Computer Software Applications, D-Egf, conformation, Family Receptors, C-erb, Transforming Growth Factor alpha, mor1, Transforming Growth Factor alpha Receptor, Computer, mENA, EK2-6, anon-WO0118547.380, c-erbB-1 Protein, c erbB 1 Protein, c-erbB, EGFr, Egfr, torpedo/Egfr, EGF receptor activity, TOP, Egf-r, erbB-1, familial adenomatous polyposis, MAP, Application, Open Source Softwares, EGF-R, anatomical systems, Research, VMD2, Software Application, familial adenomatous polyposis 2, Open Source Software, top, Torpedo/DER, BMD, top/flb, Computer Software Application, Family Receptor, autosomal recessive multiple colorectal adenomas, Epidermal Growth Factor-Urogastrone, signalling pathway, Tools, l(2)57EFa, time of survival, Epidermal Growth Factor Urogastrone, signal transduction by cis-phosphorylation, l(2)57Ea, Development and Research, Receptor Tyrosine-protein Kinase erbB-1, Proto-oncogene, RP50, Elp-B1RB1, Applications Software, EGF Receptor, Open Source, Epidermal Growth Factor Receptor Protein Tyrosine Kinase, MUTYH-Associated Polyposis, Computer Software, Epidermal Growth Factor Receptor Family Proteins, ErbB, TGF-alpha receptor activity, ERBB, dEGFR1, Proto-Oncogene Protein, Cell, Tool, development, Software Tool, Priority, survival, epidermal growth factor receptor activity, DmelCG10079, chemical analysis, Systems, Epidermal Growth Factor Receptor Protein-Tyrosine Kinase, Research Activities, Proto-oncogene c-ErbB-1 Protein, HER Family Receptor, DER/top, signalling cascade, Software, Dbest, top/DER, best, postnatal growth, Engineering, ERBB1, wa-2, Dialect, MYH-Associated Polyposis, Languages., Computer Programs, EGF, Egf, EFG-R, Applications Softwares, signalling process, Errp, Erbb, Epidermal Growth Factor, Der, DER, HER Family, MAP syndrome, Receptor, transforming growth factor-alpha receptor activity, assay, growth, BEST, DER/torpedo, HER1, FAP2, colorectal adenomatous polyposisEGF Receptor, Urogastrone Receptor, MUTYH-Associated Polyposis, Epidermal Growth Factor Receptor Protein Tyrosine Kinase, methionine aminopeptidase activity, EGF Receptors, Epidermal Growth Factor Receptor Family Proteins, Family Receptors, ErbB, ERBB, Transforming Growth Factor alpha, HER Family Receptors, MYH-associated polyposis, autosomal recessive familial adenomatous polyposis, Receptors, Proto-Oncogene Protein, Maps, Transforming Growth Factor alpha Receptor, c-erbB-1 Protein, Epidermal Growth Factor Receptor Family Protein, c erbB 1 Protein, ErbB-1, Epidermal Growth Factor Receptor Protein-Tyrosine Kinase, TGF alpha, 2, Proto-oncogene c-ErbB-1 Protein, HER Family Receptor, Urogastrone, familial adenomatous polyposis, erbB-1, MAP, peptidase M activity, autosomal recessive, adenomas, RUTBC3, rabGAPLP, L-methionine aminopeptidase activity, ErbB 1, familial adenomatous polyposis 2, erbB 1 Proto Oncogene Protein, TGF-alpha Receptor, RabGAP-5, ERBB1, erbB-1 Proto-Oncogene Protein, MYH-Associated Polyposis, Epidermal Growth Factor Receptor, Epidermal Growth Factor Receptor Kinase, ErbB-1 Receptor, RABGAP5, autosomal recessive multiple colorectal adenomas, Family Receptor, Epidermal Growth Factor-Urogastrone, Proto oncogene c ErbB 1 Protein, Receptor Tyrosine protein Kinase erbB 1, EGF, Transforming-Growth Factor alpha, signalling process, RUSC3, TGF-alpha, multiple colorectal, Epidermal Growth Factor, ErbB Receptor, HER Family, Epidermal Growth Factor Urogastrone, MAP syndrome, HER, Receptor, Receptor Tyrosine-protein Kinase erbB-1, c-ErbB-1 Protein, FAP2, HER1, single organism signaling., Proto-oncogene, colorectal adenomatous polyposisfalseOda2005_EGFR This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92. 2007-07-042005-01-012006-11-02MODEL246357606116729045MODEL2463576061