{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357.pdf"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357.svg"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357-biopax2.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357-biopax3.owl"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357_url.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357_urn.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357.xpp","https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357.vcml","https://www.ebi.ac.uk/biomodels/model/download/MODEL2784700357?filename=MODEL2784700357.m"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Molecular Systems Biology"],"curationStatus":["Non-curated"],"levelVersion":["L2V3"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL2784700357"],"publication_pubmed":["17437024"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Feala2007 dros mel central metabolism"],"publication_year":["2007"],"submissionId":["MODEL2784700357"],"modelFlag":["Non Kinetic"],"publication_authors":["Jacob D Feala, Laurence Coquin, Andrew D McCulloch, Giovanni Paternostro"],"first_author":["Jacob D Feala"],"publication":["17437024,\n The fruitfly Drosophila melanogaster offers promise as a genetically tractable model for studying adaptation to hypoxia at the cellular level, but the metabolic basis for extreme hypoxia tolerance in flies is not well known. Using (1)H NMR spectroscopy, metabolomic profiles were collected under hypoxia. Accumulation of lactate, alanine, and acetate suggested that these are the major end products of anaerobic metabolism in the fly. A constraint-based model of ATP-producing pathways was built using the annotated genome, existing models, and the literature. Multiple redundant pathways for producing acetate and alanine were added and simulations were run in order to find a single optimal strategy for producing each end product. System-wide adaptation to hypoxia was then investigated in silico using the refined model. Simulations supported the hypothesis that the ability to flexibly convert pyruvate to these three by-products might convey hypoxia tolerance by improving the ATP/H(+) ratio and efficiency of glucose utilization.. null, 3.\n Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA."],"submitter_mail":["msbforum@embo.org"],"submitter_affiliation":["Nature Publishing Group"],"pubmed_abstract":["The fruitfly Drosophila melanogaster offers promise as a genetically tractable model for studying adaptation to hypoxia at the cellular level, but the metabolic basis for extreme hypoxia tolerance in flies is not well known. Using (1)H NMR spectroscopy, metabolomic profiles were collected under hypoxia. Accumulation of lactate, alanine, and acetate suggested that these are the major end products of anaerobic metabolism in the fly. A constraint-based model of ATP-producing pathways was built using the annotated genome, existing models, and the literature. Multiple redundant pathways for producing acetate and alanine were added and simulations were run in order to find a single optimal strategy for producing each end product. System-wide adaptation to hypoxia was then investigated in silico using the refined model. Simulations supported the hypothesis that the ability to flexibly convert pyruvate to these three by-products might convey hypoxia tolerance by improving the ATP/H(+) ratio and efficiency of glucose utilization."],"pubmed_title":["Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis."],"pubmed_authors":["Feala Jacob D JD, Coquin Laurence L, McCulloch Andrew D AD, Paternostro Giovanni G"],"name_synonyms":["biochemical pathways, RAB8, multicellular organism metabolic process, Metabolic Process, AA409338, isolated, biodegradation, Metabolic, degradation, Process, catabolism, Processes, metabolism resulting in cell growth, melorheostosis, Metabolic Concepts, Metabolic Concept, metabolic process resulting in cell growth, Metabolic Processes, Anabolism., Concept, Metabolic Phenomena, Metabolism Concepts, Mouse Erythroleukemia cell line, Metabolism, Phenomena, Concepts, biotransformation, secretion, MEL, Mel, 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Atriphos, ML-1, Acetate, Phenomena, Manganese Salt, Magnesium Salt, secretion, (alpha-D)-Isomer, L-Isomer Alanine, Ethanoat, END, metabolism, D Lactic Acid, Metabolic Phenomenon, (L)-Alanine, CG11154, Acid, D-Glucose, multicellular organism metabolic process, True Flies, Acetic, Manganese Adenosine Triphosphate, biodegradation, Metabolic, 2-Hydroxypropanoic Acid, Glc., Hypoxemia, b-lactate, 2-Aminopropanoic acid, l(1)19Ea, Alanin, whole genome, Anhydrous Dextrose, P235, CaATP, wide, Drosophila, Deficiency, (2R)-, Pyruvate, D Glucose, Drosophila melanogasters, 2-hydroxypropanoic acid, ATPIB, MeCO2 anion, MgATP, Acids, acetic acid, Anoxemia, ORW1, Glucose Monohydrate, Calcium Salt, hypothesis, Anabolism"],"description_synonyms":["subgenus>, extent, APR, fruit fly, Public Sectors, 1200002G09Rik, Metabolisms, NetrinA, AUTSX5, Metabonomic, D430049E23Rik, Bioenergetics, nip, Metabonomics, NOVH, Measure, CCN3, QM, Oxygen Deficiencies, Dynamics Analyses, Drug Tolerance, B1, l(2)SH1330, 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