{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940-biopax2.owl","https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940-biopax3.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940_url.xml","https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940_urn.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940.vcml","https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940.m","https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940.sci","https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940.png","https://www.ebi.ac.uk/biomodels/model/download/MODEL9147232940?filename=MODEL9147232940.xpp"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Sharat Vayttaden"],"curationStatus":["Non-curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V1"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/MODEL9147232940"],"publication_pubmed":["19404460"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Ajay Bhalla 2007 PKM"],"publication_year":["2007"],"submissionId":["MODEL9147232940"],"publication_authors":["Sriram M Ajay, Upinder S Bhalla"],"first_author":["Sriram M Ajay"],"publication":["19404460,\n                            Strong inputs to neurons trigger complex biochemical events leading to synaptic plasticity. These biochemical events occur at many spatial scales, ranging from submicron dendritic spines to signals that propagate hundreds of microns from dendrites to the nucleus. ERKII is an important signaling molecule that is involved in many aspects of plasticity, including local excitability, communication with the nucleus, and control of local protein synthesis. We observed that ERKII activation spreads long distances in apical dendrites of stimulated hippocampal CA1 pyramidal neurons. We combined experiments and models to show that this >100 mum spread was too large to be explained by biochemical reaction-diffusion effects. We show that two modes of calcium entry along the dendrite contribute to the extensive activation of ERKII. We predict the occurrence of feedback between biophysical events resulting in calcium entry, and biochemical events resulting in ERKII activation. This feedback causes a switch-like propagation of ERKII activation, coupled with enhanced electrical excitability, along the apical dendrite. We propose that this propagating switch forms zones on dendrites in which plasticity is facilitated.. 1, 1.\n                            National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India."],"submitter_mail":["doqcs@ncbs.res.in"],"submitter_affiliation":["DOQCS"],"pubmed_abstract":["Strong inputs to neurons trigger complex biochemical events leading to synaptic plasticity. These biochemical events occur at many spatial scales, ranging from submicron dendritic spines to signals that propagate hundreds of microns from dendrites to the nucleus. ERKII is an important signaling molecule that is involved in many aspects of plasticity, including local excitability, communication with the nucleus, and control of local protein synthesis. We observed that ERKII activation spreads long distances in apical dendrites of stimulated hippocampal CA1 pyramidal neurons. We combined experiments and models to show that this >100 mum spread was too large to be explained by biochemical reaction-diffusion effects. We show that two modes of calcium entry along the dendrite contribute to the extensive activation of ERKII. We predict the occurrence of feedback between biophysical events resulting in calcium entry, and biochemical events resulting in ERKII activation. This feedback causes a switch-like propagation of ERKII activation, coupled with enhanced electrical excitability, along the apical dendrite. We propose that this propagating switch forms zones on dendrites in which plasticity is facilitated."],"pubmed_title":["A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity."],"pubmed_authors":["Ajay Sriram M SM, Bhalla Upinder S US"],"additional_accession":[]},"is_claimable":false,"name":"Ajay_Bhalla_2007_PKM","description":"\n      \n    This is a non-bistable model of ERKII signaling that also incorporates PKM synthesis triggered by Ca influx. It is a simplified variant of the model of Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80.    This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team.      \n          To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to      CC0 Public Domain Dedication\n          for more information.      \n    In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..      \n    \n          To cite BioModels Database, please use:      Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.\n\n\n","dates":{"last_modification":"2011-04-05","publication":"2005-01-01","submission":"2008-03-13"},"accession":"MODEL9147232940","cross_references":{"pubmed":["19404460"],"biomodels__db":["MODEL9147232940"],"go":["GO:0070371"],"taxonomy":["10114"],"bto":["BTO:0000601"]}}