{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"submitter":["CBDM Lab"],"organism":["Mus musculus"],"software":["MicroArraySuite 5.0"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-GEOD-1112"],"description":["Four independent chip hybridization with RNAs from four independent RTOC cultures."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Hybridization - Title: Affymetrix Generic Hybridization. Description:"],"figure_sub":["MIAME Score","Raw Data","Organization","Assays and Data","MAGE-TAB Files","Array Designs"],"data_protocol":["Feature Extraction - Title: Affymetrix CEL analysis. Description:"],"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"pubmed_abstract":["Thymocytes displaying self-reactive T cell receptors usually undergo negative selection in the thymus. Here we demonstrate that agonist peptides can promote positive selection of immature double-positive thymocytes into distinct lineages, varying with the agonist concentration and the animal's age. Microarray gene expression analyses showed broad transcriptional alterations in a set of transcripts associated with the innate immune system, as well as silencing of CD8 beta expression. The resulting CD8 alpha alpha T cells showed a rapid effector cytokine response. Hence, T cells displaying self-reactive receptors can have the gene expression profile and phenotypic characteristics of innate immune cells."],"study_type":["transcription profiling by array"],"species":["Mus musculus"],"pubmed_title":["Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells."],"pubmed_authors":["Tetsuya Yamagata, Diane Mathis, Christophe Benoist","CBDM Lab"],"additional_accession":[]},"is_claimable":false,"name":"Transcription profiling of mouse RTOC cell cultures","description":"Four independent chip hybridization with RNAs from four independent RTOC cultures.","dates":{"release":"2007-11-08T00:00:00Z","modification":"2023-08-01T05:33:47.821Z","creation":"2022-02-03T05:33:12.188Z"},"accession":"E-GEOD-1112","cross_references":{"pubmed":["15133507"],"EFO":["EFO_0002768"],"doi":["10.1038/ni1070"]}}