biostudies-arrayexpressMetabolomicsUnknownTranscriptomicsGenomicsProteomicsMichael GeorgeHepatitis C virus (HCV) Core protein is implicated in the development of hepatocellular carcinoma (HCC). We utilized a HepG2 human hepatocyte cell line with inducible expression of HCV Core protein (HCV-1b) to investigate the early effects of Core protein on hepatocyte gene expression and to identify molecular processes modulated by the Core protein. A significant change was observed in the expression of 407 genes, which included genes regulating apoptosis, immune response, and cell cycle. Some of these genes were previously known to be tumor markers. The decreased expression of chemo-attractants such as TNFSF10, CCL20, and osteopontin was observed, which suggested that HCV Core expression could lead to suppression of inflammatory response as well as trafficking of macrophages and neutrophtranscription profiling by arrayHomo sapiensHomo sapienshttps://www.ebi.ac.uk/biostudies/studies/E-GEOD-2067Gene expression in HepG2 cell linebiostudies-arrayexpressHepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes.MIAME ScoreOrganizationAssays and DataMAGE-TAB FilesArray DesignsHau Nguyen, Sumathi Sankaran, Satya DandekarMichael GeorgefalseTranscription profiling of human HepG2 cell lines reveals hepatitis C virus core proten induces expression of genes regulating immune invasion and anti-apoptosisGene expression in HepG2 cell line2007-10-02T00:00:00Z2023-08-07T02:33:15.684Z2022-03-15T12:16:37.26ZE-GEOD-206716876223EFO_000276816876223