{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"submitter":["Amit Dutt"],"instrument_platform":["Illumina NovaSeq 6000"],"study_type":["exome sequencing"],"organism":["Homo sapiens"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-13697"],"description":["The study involves whole exome sequencing of 38 orphan primary tumors obtained from anaplastic thyroid carcinoma patients of Indian origin. With this, we aim to  describe the mutational profile of this specific subset of anaplastic thyroid cancer patients. This knowledge will further allow us to gain an insight into potentially actionable genomic alterations prevalent in Indian anaplastic thyroid carcinoma."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Sample Collection - The FFPE tumor tissues were collected from ACTREC-TMC","Library Construction - Using the Illumina DNA Prep with enrichment Kit, formerly known as the TruSeq DNA Access Library Prep Kit, whole exome sequencing was done on 38 FFPE samples of anaplastic thyroid cancer.","Nucleic Acid Extraction - The 38 FFPE orphan tumor samples has been subjected to microtome-sectioning where ~5-6 sections of 10 um has been taken based on the tissue abundance for DNA extraction. The DNA extraction from has been performed according to standard protocol of Qiagen's DNeasy FFPE tissue kits. The DNA concentration was measured using Nanodrop 2000c spectrophotometer.","Sequencing - 38 samples' whole exome sequencing libraries were put into the Novaseq 6000 platform at 4basecare Pvt. Ltd., Bangalore, for 2 X 150 bp paired-end sequencing"],"figure_sub":["Organization","MINSEQE Score","Assays and Data","MAGE-TAB Files"],"pubmed_authors":["Amit Dutt"],"additional_accession":[]},"is_claimable":false,"name":"Whole exome sequencing of anaplastic thyroid cancer of Indian origin","description":"The study involves whole exome sequencing of 38 orphan primary tumors obtained from anaplastic thyroid carcinoma patients of Indian origin. With this, we aim to  describe the mutational profile of this specific subset of anaplastic thyroid cancer patients. This knowledge will further allow us to gain an insight into potentially actionable genomic alterations prevalent in Indian anaplastic thyroid carcinoma.","dates":{"release":"2025-07-01T00:00:00Z","modification":"2024-01-10T21:25:46.808Z","creation":"2024-01-10T21:25:46.808Z"},"accession":"E-MTAB-13697","cross_references":{"ENA":["ERP156556"],"EFO":["EFO_0002944","EFO_0005396","EFO_0004170","EFO_0005518","EFO_0004184"]}}