biostudies-arrayexpressHomo sapienshttps://www.ebi.ac.uk/biostudies/studies/E-MTAB-15004Characterize the transcriptomes of CLL with and without t(14;19)biostudies-arrayexpressNucleic Acid Extraction - Total RNA was extracted with the RNeasy Mini Kit (Qiagen, Hilden, Germany) and treated with DNase (Qiagen), according to the manufacturer’s protocolSample Collection - 10^6 leukemic B cells from CLL patients. B cells were purified by negative selection using RosetteSep™ B cell enrichment Cocktail (StemCell Technologies, Vancouver, Canada)Library Construction - Illumina Stranded mRNA Prep kit but replacing the messenger RNA capture phase with ribosomal RNA depletion performed with the Qiagen Qiaseq Fastselect HMR kit.Sequencing - 150bp paired-end reads on Illumina NovaSeq 6000 (Illumina, Inc., San Diego, California - USA)MINSEQE ScoreAssays and DataProcessed DataorganisationMAGE-TAB FilesData Transformation - Fastq data were processed with the CirComPara2 software pipeline; raw counts for genes were computed with the tximport-DESeq2 procedure from the StringTie2 outputMetabolomicsUnknownTranscriptomicsGenomicsProteomicsIllumina NovaSeq 6000RNA-seq of total RNAHomo sapiensCircular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.ERP171265Visentin A, Gaffo E, Fürstenau M, Rogers KA, Panagiotis B, Cui C, Miller C, Haferlach C, Plevova K, Oscier D, Davis Z, Nguyen-Khac F, Roncaglia E, Rigolin GM, Athanasiadou A, Baran-Marszak F, Valiente A, Terol MJ, Abrisqueta P, Espinet B, Puiggros A, Martines A, Bonaldi L, Mauro FR, Scarfò L, Chatzikonstantinou T, Tausch E, Kreuzer KA, Kater A, Bosch F, Doubek M, Panagiotidis P, Kalashnikova O, Frezzato F, Calabretto G, Ruocco V, Orsi S, Cellini A, Angotzi F, Serafin A, Yi S, Eichhorst B, Woyach JA, Cuneo A, Ghia P, Stamatopoulos K, Trentin L, Bortoluzzi S.Enrico GaffoAndrea VisentinRoncaglia E, Gaffo E, Calabretto G, Fürstenau M, Rogers KA, Baliakas P, Cui C, Miller C, Haferlach C, Plevova K, Oscier D, Davis Z, Nguyen-Khac F, Rigolin GM, Athanasiadou A, Baran-Marszak F, Valiente A, Terol MJ, Abrisqueta P, Espinet B, Puiggros A, Martines A, Bonaldi L, Mauro FR, Scarfò L, Chatzikonstantinou T, Tausch E, Kreuzer KA, Kater A, Bosch F, Doubek M, Panagiotidis P, Kalashnikova O, Frezzato F, Ruocco V, Orsi S, Salek K, Merlo R, Caregari A, Glogovitis I, Cellini A, Angotzi F, Serafin A, Yi S, Eichhorst B, Woyach JA, Cuneo A, Ghia P, Stamatopoulos K, Trentin L, Visentin A, Bortoluzzi S.falseRNA-seq of Chronic Lymphocytic Leukemia patients with and without t(14;19) samples, and normal mature B cellsCharacterize the transcriptomes of CLL with and without t(14;19)2026-07-14T00:00:00Z2026-07-14T13:16:33.131Z2025-04-04T09:45:28.29ZE-MTAB-15004publ-0-eenf-removablepubl-1-h7rg-removableERP171265EFO_0002944EFO_0004170EFO_0009653EFO_0005518EFO_0003816EFO_000418410.1186/s13045-025-01725-y10.1038/s41375-025-02755-8