{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"submitter":["Lízia Branco"],"instrument_platform":["Illumina NovaSeq 6000"],"study_type":["RNA-seq of coding RNA"],"organism":["Homo sapiens"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-15191"],"description":["This dataset contains RNA sequencing data of 48 human dorsal forebrain organoids on day 50 of differentiation. Half of the samples were treated with the antiepileptic drug valproic acid (VPA) from day 21 to day 50 of differentiation, while the remaining served as untreated controls. This dataset was generated to investigate how VPA influences early human cortical development at the transcriptional level."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Nucleic Acid Extraction - mRNA was isolated from organoids using the RNeasy MiniKit (Qiagen, Cat. no.74106) following manufacturer’s instructions","Sequencing - Paired-end 150 bp","Sample Collection - Organoids were homogenized in the RLT buffer from RNeasy MiniKit (Qiagen, Cat. no.74106) on ice, and stoted at -80C until RNA extraction.","Library Construction - non-directional poly-A enrichment"],"figure_sub":["Organization","MINSEQE Score","Assays and Data","MAGE-TAB Files"],"pubmed_authors":["Zeynep Yentür","Lízia Branco"],"additional_accession":[]},"is_claimable":false,"name":"RNA sequencing data of human dorsal forebrain organoids treated with valproic acid against untreated controls","description":"This dataset contains RNA sequencing data of 48 human dorsal forebrain organoids on day 50 of differentiation. Half of the samples were treated with the antiepileptic drug valproic acid (VPA) from day 21 to day 50 of differentiation, while the remaining served as untreated controls. This dataset was generated to investigate how VPA influences early human cortical development at the transcriptional level.","dates":{"release":"2026-02-11T00:00:00Z","modification":"2026-02-11T07:43:15.29Z","creation":"2025-06-03T12:29:47.123Z"},"accession":"E-MTAB-15191","cross_references":{"ENA":["ERP173130"],"EFO":["EFO_0002944","EFO_0004170","EFO_0005518","EFO_0003738","EFO_0004184"]}}