{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"submitter":["Beatrice Bodega"],"instrument_platform":["NextSeq 2000"],"study_type":["RNA-seq of coding RNA"],"organism":["Homo sapiens"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-15363"],"description":["In this study, RNA-sequencing was performed on 9 early-onset colorectal cancer (EO-CRC) samples, 8 adjacent normal tissues, and 5 liver metastases. The resulting data were analyzed to characterize gene expression profiling and to explore the activity of transposable elements. This analysis revealed that EO-CRC specifically reactivates placental-like transcriptional features associated with early developmental reprogramming, sustained by the expression of HERVH, a family of retrotransposons involved in the maintenance of pluripotency"],"repository":["biostudies-arrayexpress"],"sample_protocol":["Sample Collection - Tumor, normal adjacent, and metastatic specimens derived from EO-CRC human biopsies were homogenized in Promega Homogenization Buffer.","Sequencing - Paired end, 100/120bp reads, Illumina NextSeq 2000.","Library Construction - Total RNAseq libraries were prepared using SMARTer Stranded RNA-Seq kit from Takara.","Nucleic Acid Extraction - RNA has been extracted with Maxwell RCS simplyRNA Cells kit"],"figure_sub":["Organization","MINSEQE Score","Assays and Data","MAGE-TAB Files"],"pubmed_authors":["Beatrice Bodega","Valeria Ranzani"],"additional_accession":[]},"is_claimable":false,"name":"RNA-sequencing of Early-Onset Colorectal Cancer (EOCRC) samples, normal adjacent tissue and metastasis","description":"In this study, RNA-sequencing was performed on 9 early-onset colorectal cancer (EO-CRC) samples, 8 adjacent normal tissues, and 5 liver metastases. The resulting data were analyzed to characterize gene expression profiling and to explore the activity of transposable elements. This analysis revealed that EO-CRC specifically reactivates placental-like transcriptional features associated with early developmental reprogramming, sustained by the expression of HERVH, a family of retrotransposons involved in the maintenance of pluripotency","dates":{"release":"2026-09-14T00:00:00Z","modification":"2026-09-14T14:00:52.669Z","creation":"2025-07-16T21:16:29.612Z"},"accession":"E-MTAB-15363","cross_references":{"ENA":["ERP176874"],"EFO":["EFO_0002944","EFO_0004170","EFO_0005518","EFO_0003738","EFO_0004184"]}}