{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown","Transcriptomics","Genomics","Proteomics"],"submitter":["Kathryn Schunke"],"study_type":["transcription profiling by array"],"organism":["Rattus norvegicus"],"species":["Rattus norvegicus"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-15425"],"description":["We have evidence that Zmynd8 is an epigenetic reader than alters the capability of HIF-1a to bind to its target genes in hypoxia.  HIF-1a directly upregulates Zmynd8, thereby working in a negative feedback loop.  We aimed to determine if knocking down Zmynd8 in the hypoxic setting would promote HIF-1a mediated transcription."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Scaning - Samples were processed and array scanning was done according to the standard Clariom D sample processing protocol.","Nucleic Acid Extraction - RNA was extracted using Qiagen RNeasy Mini kit according to the manufactures recommendations.","Labeling - Samples were processed and nucleic acid was labeled according to the standard Clariom D sample processing protocol.","Hybridization - Samples were processed and hybridization was performed according to the standard Clariom D sample processing protocol.","Sample Collection - 10cm plates were washed with ice cold PBS and processed for mRNA extraction"],"figure_sub":["MIAME Score","Raw Data","Organization","Assays and Data","MAGE-TAB Files","Array Designs"],"pubmed_authors":["Kathryn Schunke"],"additional_accession":[]},"is_claimable":false,"name":"Zmynd8 influences the expression of HIF-1α target genes","description":"We have evidence that Zmynd8 is an epigenetic reader than alters the capability of HIF-1a to bind to its target genes in hypoxia.  HIF-1a directly upregulates Zmynd8, thereby working in a negative feedback loop.  We aimed to determine if knocking down Zmynd8 in the hypoxic setting would promote HIF-1a mediated transcription.","dates":{"release":"2025-08-23T00:00:00Z","modification":"2025-07-31T22:27:30.397Z","creation":"2025-07-31T22:27:30.397Z"},"accession":"E-MTAB-15425","cross_references":{"EFO":["EFO_0002768","EFO_0002944","EFO_0003814","EFO_0003813","EFO_0005518","EFO_0003815"]}}