{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"submitter":["David McVey"],"organism":["Homo sapiens"],"software":["Not applicable"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-15426"],"description":["Methylation profiling by EPIC microarray was performed on 3 human umbilical artery smooth muscle cells (HUASMCs) and human aortic smooth muscle cells (HAoSMCs) to assess CpG methylation in proximity to cardiovascular disease-associated variants."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Labeling - This was performed at a microarray service provider (Barts and the London Genome Centre).","Sample Collection - HUASMCs were isolated from umbilical cord tissue by dissection of the cord to isolate the umbilical artery. The artery was dissected and smooth muscle cells isolated using the tissue explant method.  Aortic SMCs (HAoSMCs) were purchased.","Nucleic Acid Extraction - Nucleic acids were isolated using the GenElute Mammalian Genomic DNA Miniprep Kit (Sigma-Aldrich G1N70)","Hybridization - This was performed at a microarray service provider (Barts and the London Genome Centre).","Scaning - This was performed at a microarray service provider (Barts and the London Genome Centre)."],"figure_sub":["MIAME Score","Raw Data","Organization","Assays and Data","MAGE-TAB Files","Array Designs"],"omics_type":["Unknown","Transcriptomics","Genomics","Proteomics"],"study_type":["methylation profiling by array"],"species":["Homo sapiens"],"pubmed_title":["Integrative functional genomics analysis identifies pleiotropic genes for vascular diseases"],"pubmed_authors":["David McVey","Charles U. Solomon*, David G. McVey*, Catherine Andreadi, Peng Gong, Lenka Turner,  Dedrick S. Song, Heming Zhang, Dominic Paul Lee, Elisavet Karamanavi, Wei Yang, Runji Chen, Kim E. Haworth, Chukwuemeka George Anene-Nzelu, Hui Li, Matthew J. Denniff, Peter Y. Li, Yanhong Zhang, Xiaoxin Huang, Gavin E. Morris, Peter A Greer, Emma J Stringer, Haojie Yu, Roger S. Y. Foo, Gillian Douglas, Nilesh J. Samani, Tom R. Webb, Shu Ye","Shu Ye"],"additional_accession":[]},"is_claimable":false,"name":"Methylation profiling by EPIC microarray of human umbilical artery smooth muscle cells (HUASMCs) and human aortic smooth muscle cells (HAoSMCs)","description":"Methylation profiling by EPIC microarray was performed on 3 human umbilical artery smooth muscle cells (HUASMCs) and human aortic smooth muscle cells (HAoSMCs) to assess CpG methylation in proximity to cardiovascular disease-associated variants.","dates":{"release":"2025-12-01T00:00:00Z","modification":"2025-12-01T02:01:49.5Z","creation":"2025-07-31T22:41:07.218Z"},"accession":"E-MTAB-15426","cross_references":{"EFO":["EFO_0002944","EFO_0003814","EFO_0003813","EFO_0002759","EFO_0005518","EFO_0003815"]}}