biostudies-arrayexpressMetabolomicsUnknownTranscriptomicsGenomicsProteomicsHelen Parkermethylation profiling by arrayHomo speciesHomo specieshttps://www.ebi.ac.uk/biostudies/studies/E-MTAB-15593High genomic complexity (HGC) is linked to poor prognosis in chronic lymphocytic leukaemia (CLL), but its independent prognostic value remains uncertain amid emerging biomarkers. Therefore we analysed copy number alterations in 495 treatment-naïve patients from three randomized trials (CLL4, ADMIRE, ARCTIC), incorporating IGHV status, telomere length (TL), targeted sequencing, and DNA-methylation subtypes.biostudies-arrayexpressLabeling - Bisulphite treatmentHybridization - Infinium assayScaning - RnBeads v2.93Nucleic Acid Extraction - Qiagen DNeasy column extractionSample Collection - peripheral blood mononuclear cell sample taken by venipunctureMIAME ScoreRaw DataOrganizationAssays and DataMAGE-TAB FilesArray DesignsHelen ParkerfalseCopy number profiling of Chronic lymphocytic leukaemia patientsHigh genomic complexity (HGC) is linked to poor prognosis in chronic lymphocytic leukaemia (CLL), but its independent prognostic value remains uncertain amid emerging biomarkers. Therefore we analysed copy number alterations in 495 treatment-naïve patients from three randomized trials (CLL4, ADMIRE, ARCTIC), incorporating IGHV status, telomere length (TL), targeted sequencing, and DNA-methylation subtypes.2026-04-01T00:00:00Z2026-04-02T01:05:06.523Z2025-09-12T12:47:50.194ZE-MTAB-15593EFO_0002944EFO_0003814EFO_0003813EFO_0002759EFO_0005518EFO_0003815