{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"submitter":["helen Parker"],"instrument_platform":["Illumina NovaSeq 6000"],"study_type":["DNA-seq"],"organism":["Homo sapiens"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-15598"],"description":["High genomic complexity (HGC) is linked to poor prognosis in chronic lymphocytic leukaemia (CLL), but its independent prognostic value remains uncertain amid emerging biomarkers. Therefore we analysed copy number alterations in 495 treatment-naïve patients from three randomized trials (CLL4, ADMIRE, ARCTIC), incorporating IGHV status, telomere length (TL), targeted sequencing, and DNA-methylation subtypes."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Sample Collection - Peripheral blood mononuclear cell sample via venipuncture","Library Construction - SureSelect Xt HS2 DNA library preparation kit","Nucleic Acid Extraction - Qiagen DNeasy column extraction","Sequencing - Illumina Novoseq 6000"],"figure_sub":["Organization","MINSEQE Score","Assays and Data","MAGE-TAB Files"],"pubmed_authors":["helen Parker"],"additional_accession":[]},"is_claimable":false,"name":"Mutational analysis of CLL patient samples","description":"High genomic complexity (HGC) is linked to poor prognosis in chronic lymphocytic leukaemia (CLL), but its independent prognostic value remains uncertain amid emerging biomarkers. Therefore we analysed copy number alterations in 495 treatment-naïve patients from three randomized trials (CLL4, ADMIRE, ARCTIC), incorporating IGHV status, telomere length (TL), targeted sequencing, and DNA-methylation subtypes.","dates":{"release":"2026-04-01T00:00:00Z","modification":"2026-04-02T01:05:03.556Z","creation":"2025-09-17T21:53:02.622Z"},"accession":"E-MTAB-15598","cross_references":{"ENA":["ERP180257"],"Biostudies":["E-MTAB-15593"],"EFO":["EFO_0002944","EFO_0004170","EFO_0002693","EFO_0005518","EFO_0004184"]}}