biostudies-arrayexpressMetabolomicsUnknownTranscriptomicsGenomicsProteomicsKWANWOO LEEIon Torrent ProtonRNA-seq of coding RNAMus musculusMus musculushttps://www.ebi.ac.uk/biostudies/studies/E-MTAB-15958This study aimed to investigate the transcriptomic changes in the mouse brain following oral administration of theogallin. Whole-brain tissues were collected from 13-week-old male mice (C57BL/6J) treated with theogallin or vehicle control. Total RNA was extracted and subjected to RNA sequencing (RNA-seq) to assess differential gene expression associated with theogallin exposure. The dataset provides a foundation for investigating the therapeutic benefits of theogallin in age-associated cognitive disorders. IonXpress_033~036; BC groups, IonXpress_037~040; BT groupsbiostudies-arrayexpressSample Collection - Whole brain was collected from 13-week-old male mice that were orally administered theogallin for 1 weeks. Brains were rapidly dissected, snap-frozen in liquid nitrogen, and stored at −80°C until RNA extraction.Library Construction - libraries were prepared with Ion AmpliSeq Transcriptome Mouse Gene Expression Kit (Thermo Fisher Scientific) according to the manufacturer’s instructions.Sequencing - libraries were sequenced on the Ion Proton™ system using IonXpress™ Chip Type P1.1.17 (Thermo Fischer Scientific)Nucleic Acid Extraction - Total RNA was extracted from whole brain tissues using TRIzol reagent (Thermo Fisher Scientific) according to the manufacturer’s instructions. RNA concentration and integrity were assessed with a NanoDrop spectrophotometer and Agilent Bioanalyzer.OrganizationMINSEQE ScoreAssays and DataMAGE-TAB FilesKWANWOO LEEfalseRNA-seq analysis of whole-brain samples from mice orally administered with TheogallinThis study aimed to investigate the transcriptomic changes in the mouse brain following oral administration of theogallin. Whole-brain tissues were collected from 13-week-old male mice (C57BL/6J) treated with theogallin or vehicle control. Total RNA was extracted and subjected to RNA sequencing (RNA-seq) to assess differential gene expression associated with theogallin exposure. The dataset provides a foundation for investigating the therapeutic benefits of theogallin in age-associated cognitive disorders. IonXpress_033~036; BC groups, IonXpress_037~040; BT groups2025-12-22T00:00:00Z2025-12-22T02:01:21.79Z2025-11-01T18:15:38.106ZE-MTAB-15958ERP183507EFO_0002944EFO_0004170EFO_0005518EFO_0003738EFO_0004184