biostudies-arrayexpressYe LiuMus musculushttps://www.ebi.ac.uk/biostudies/studies/E-MTAB-16167To examine the impaired osteoclastogenic program in Senp6^LysM BMMs, we performed ATAC-seq on WT and Senp6^LysM BMMs stimulated with RANKL for 0 h (R0), 16 h (R16), and 36 h (R36), corresponding to sequential stages of early osteoclastogenesis.biostudies-arrayexpressLibrary Construction - BMM from Ctrl and Senp6LysM (n = 2) mice were seeded into 12-well plates, followed by RANKL treatment for 0 hours (untreated), 16 hours, or 36 hours. 50,000 cells/nuclei per sample were used for ATAC-seq library preparation according to the omni-ATAC protocolSequencing - NovaSeq 6000,2x100bpSample Collection - BMM from Ctrl and Senp6LysM (n = 2) mice were seeded into 12-well plates, followed by RANKL treatment for 0 hours (untreated), 16 hours, or 36 hours. 50,000 cells/nuclei per sample were used for ATAC-seq library preparation according to the omni-ATAC protocolNucleic Acid Extraction - BMM from Ctrl and Senp6LysM (n = 2) mice were seeded into 12-well plates, followed by RANKL treatment for 0 hours (untreated), 16 hours, or 36 hours. 50,000 cells/nuclei per sample were used for ATAC-seq library preparation according to the omni-ATAC protocolOrganizationMINSEQE ScoreAssays and DataMAGE-TAB FilesMetabolomicsUnknownTranscriptomicsGenomicsProteomicsIllumina NovaSeq 6000ATAC-seqMus musculusThe deSUMOlyase SENP6 represses transposable elements-induced innate immune response to support osteoclastogenesisYe Liu; Huadie Liu; Vladimir Molchanov; Yaguang Zhao; Saumya Bhagat; Lukai Zhai; Minmin Liu; Di Lu; H. Josh Jang; Tao YangYe LiufalseATAC-seq of mouse bone-marrow–derived macrophages and osteoclast precursors (BMM, RANKL-16h, RANKL-36h) from wild-type and Senp6 conditional knockout miceTo examine the impaired osteoclastogenic program in Senp6^LysM BMMs, we performed ATAC-seq on WT and Senp6^LysM BMMs stimulated with RANKL for 0 h (R0), 16 h (R16), and 36 h (R36), corresponding to sequential stages of early osteoclastogenesis.2026-09-28T00:00:00Z2026-09-28T15:04:48.172Z2025-11-17T15:19:37.115ZE-MTAB-16167ERP185180EFO_0002944EFO_0007045EFO_0004170EFO_0005518EFO_0004184