biostudies-arrayexpressDaniel FinkeMus musculushttps://www.ebi.ac.uk/biostudies/studies/E-MTAB-16361The knowledge of the molecular basis of anthracycline-induced cardiotoxicity is still limited. We assessed the transcriptional alterations in the murine heart (LV) after Doxorubicin treatment and HDACi (SAHA) at different time points in C57BL6 WT and HDAC4 cardiomyocyte-specific knockouts (HDAC4-cKO).biostudies-arrayexpressSequencing - Sequencing was performed on a DNBseq platform at BGI.Sample Collection - Mice were injected either with NaCl, Doxorubicin (3mg/kg BW), SAHA (12,5 mg/kg BW) or a combination of Doxorubicin and SAHA in the same concentrations. Cardiac tissue was harvested from mice at the end of the experiment. The tissue was frozen in liquid Nitrogen and stored at -80°C untill the isolation of RNA.Library Construction - RNA libraries of the coding RNA (Poly-A) were prepared at BGI.Nucleic Acid Extraction - RNA was isolated using Qiazol reagents (Qiagen), followed by precipitation. RNA was eluted in RNAse-free water.OrganizationMINSEQE ScoreAssays and DataProcessed DataMAGE-TAB FilesData Transformation - The files were annotated to the mouse genome (mm9).MetabolomicsUnknownTranscriptomicsGenomicsProteomicsDNBSEQ-G400RNA-seq of coding RNAMus musculusDaniel FinkefalseBulk RNA-seq from murine left ventricels after Doxorubicin and HDACi co-treatmentThe knowledge of the molecular basis of anthracycline-induced cardiotoxicity is still limited. We assessed the transcriptional alterations in the murine heart (LV) after Doxorubicin treatment and HDACi (SAHA) at different time points in C57BL6 WT and HDAC4 cardiomyocyte-specific knockouts (HDAC4-cKO).2026-08-17T00:00:00Z2026-08-17T01:00:43.541Z2025-12-03T01:38:54.111ZE-MTAB-16361ERP185988EFO_0002944EFO_0004170EFO_0005518EFO_0003816EFO_0003738EFO_0004184