{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"submitter":["Mette Ludwig Q."],"organism":["Mus musculus"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-17123"],"description":["Bulk RNA sequencing of the hippocampus from mice treated with semaglutide or vehicle control prior to lipopolysaccharide (LPS)-induced neuroinflammation."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Sequencing - cDNA libraries were sequenced on a NextSeq 500 using NextSeq 500/550 High Output Kit V2 (Illumina)","Sample Collection - Samples were collected and snap-frozen in liquid nitrogen and stored at -80°C","Nucleic Acid Extraction - RNA was isolated using the NucleoSpin® kit (MACHEREY-NAGEL)","Library Construction - A total of 10 ng-1 µg purified RNA from each sample was used to generate a cDNA library using the NEBNext® Ultra™ II Directional RNA Library Prep Kit for Illumina (New England Biolabs)"],"figure_sub":["Organization","MINSEQE Score","Assays and Data","Processed Data","MAGE-TAB Files"],"data_protocol":["Data Transformation - Raw counts are provided","Sequence Alignment - The bulk RNA-seq data was aligned to the mouse genome obtained from the Ensembl database using the Spliced Transcripts Alignment to a Reference (STAR) software"],"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"instrument_platform":["NextSeq 500"],"study_type":["RNA-seq of coding RNA"],"species":["Mus musculus"],"pubmed_title":["Semaglutide Attenuates Neuroinflammation in Mice"],"pubmed_authors":["Dylan M. Rausch, Mette Q. Ludwig, Marie A. Bentsen, Stine N. Hansen, Anna Secher, Dorte Holst, Jaime Moreno, Vivek Das, Kristoffer L. Egerod, Anne-Mette Bjerregaard, Kristoffer Niss, Sarah Bau, Charles Pyke, Kevin Dalgaard, Myrte Merkestein, Franziska Wichern, Charlotte Thim Hansen, Joseph Polex-Wolf, Lotte Bjerre Knudsen & Tune H. Pers","Mette Ludwig Q."],"additional_accession":[]},"is_claimable":false,"name":"Semaglutide Attenuates Neuroinflammation in Mice","description":"Bulk RNA sequencing of the hippocampus from mice treated with semaglutide or vehicle control prior to lipopolysaccharide (LPS)-induced neuroinflammation.","dates":{"release":"2026-07-01T00:00:00Z","modification":"2026-07-01T01:04:21.446Z","creation":"2026-05-27T13:52:04.098Z"},"accession":"E-MTAB-17123","cross_references":{"ENA":["ERP194053"],"Biostudies":["E-MTAB-16829"],"EFO":["EFO_0002944","EFO_0004170","EFO_0004917","EFO_0005518","EFO_0003816","EFO_0003738","EFO_0004184"]}}