{"database":"biostudies-arrayexpress","file_versions":[],"scores":null,"additional":{"omics_type":["Metabolomics","Unknown","Transcriptomics","Genomics","Proteomics"],"submitter":["Kristian Almstrup"],"study_type":["methylation profiling by array"],"organism":["Homo sapiens"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/E-MTAB-17259"],"description":["The Copenhagen Analgesic Study (COPANA) (ClinicalTrials.gov ID: NCT04369222) is a single-center, prospective, observational pregnancy and birth cohort from Copenhagen University Hospital - Rigshospitalet, Denmark. This data represents blood DNA methylation analysis of the children using Illumina EPICv2 beadarrays.  The infants are divided into groups depending on: Paternal use of paracetamol / Maternal use of paracetamol / Maternal use of fungizides Pattern Group 0/0/0 A 0/0/1 B 0/0/NA C 0/1/0 D 0/1/1 E 0/1/NA F 1/0/0 G 1/0/1 H 1/0/NA I 1/1/0 J 1/1/1 K 1/1/NA L NA/0/0 M NA/0/1 N NA/1/0 O NA/1/1 P NA/1/NA Q  Where 1 implies exposure, 0 implies no exposure, and NA implies not available."],"repository":["biostudies-arrayexpress"],"sample_protocol":["Nucleic Acid Extraction - DNA was purified from infant blood samples using the automated Maxwell 16 system (SEV AS1010, Promaga, Madison, WI, USA) and quantified by NanoDrop (Life Technologies Europe BV, Naerum, Denmark).","Labeling - Bisulfite-treatment of DNA according to Illumina standard protocols.","Scaning - Illumina iScan system, and probe intensities extracted in GenomeStudio","Hybridization - Illumina standard protocols following the manufacturer's recommendations.","Sample Collection - At three months postpartum, blood samples were obtained from infants"],"figure_sub":["MIAME Score","Raw Data","Organization","Assays and Data","Processed Data","MAGE-TAB Files","Array Designs"],"pubmed_authors":["Kristian Almstrup"],"data_protocol":["Data Transformation - Data were processed with the minfi R package and normalised using Subset-quantile Within Array Normalisation, and probes containing SNPs in the CpG or extension sites were removed."],"additional_accession":[]},"is_claimable":false,"name":"COPAPA DNA methylation","description":"The Copenhagen Analgesic Study (COPANA) (ClinicalTrials.gov ID: NCT04369222) is a single-center, prospective, observational pregnancy and birth cohort from Copenhagen University Hospital - Rigshospitalet, Denmark. This data represents blood DNA methylation analysis of the children using Illumina EPICv2 beadarrays.  The infants are divided into groups depending on: Paternal use of paracetamol / Maternal use of paracetamol / Maternal use of fungizides Pattern Group 0/0/0 A 0/0/1 B 0/0/NA C 0/1/0 D 0/1/1 E 0/1/NA F 1/0/0 G 1/0/1 H 1/0/NA I 1/1/0 J 1/1/1 K 1/1/NA L NA/0/0 M NA/0/1 N NA/1/0 O NA/1/1 P NA/1/NA Q  Where 1 implies exposure, 0 implies no exposure, and NA implies not available.","dates":{"release":"2026-06-26T00:00:00Z","modification":"2026-06-26T01:01:10.113Z","creation":"2026-06-23T20:11:02.454Z"},"accession":"E-MTAB-17259","cross_references":{"EFO":["EFO_0002944","EFO_0003814","EFO_0003813","EFO_0002759","EFO_0005518","EFO_0003816","EFO_0003815"]}}